Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe : findings from the ERA Registry
Abd ElHafeez, Samar (Alexandria University (Egipte))
Kramer, A. (Universiteit van Amsterdam)
Arici, Mustafa (Hacettepe University (Ancara, Turquia))
Arnol, Miha (Univerza V Ljubljani)
Åsberg, Anders (Oslo University Hospital (Oslo, Noruega))
Bell, Samira (The University of Dundee (Regne Unit))
Belliere, Julie (University of Dundee)
Díaz-Corte, Carmen (Hospital Universitario Central de Asturias)
Fernández Fresnedo, Gema (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Hemmelder, Marc (University of Maastricht)
Heylen, Line (University Hasselt)
Hommel, Kristine (Holbaek Hospital)
Kerschbaum, J. (Medical University Innsbruck)
Naumović, Radomir (University of Belgrade)
Nitsch, Dorothea (London School of Hygiene and Tropical Medicine)
Santamaría, Rafael (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Finne, Patrik (Helsinki University Central Hospital)
Palsson, Runolfur (University of Iceland)
Pippias, Maria (University of Bristol)
Resić, Halima (Clinical Center University of Sarajevo)
Rosenberg, Mai (Tartu University Hospital (Tartu, Estònia))
Santiuste de Pablos, Carmen (Tartu University Hospital (Tartu, Estònia))
Segelmark, M. (Instituto Murciano de Investigación Biosanitaria)
Sørensen, Søren Schwartz (Copenhagen University Hospital)
Soler, María José (Hospital Universitari Vall d'Hebron)
Vidal, Enrico (University of Udine)
Jager, Kitty (Universiteit van Amsterdam)
Ortiz, Alberto (Universidad Autonóma de Madrid)
Stel, Vianda S. (Universiteit van Amsterdam)

Data:	2024
Resum:	Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups. We examined age and sex standardized incidence, trend of the incidence and survival. The standardized incidence of KRT for ESKD due to PGD was 16. 6 per million population (pmp), ranging from 8. 6 pmp in Serbia to 20. 0 pmp in France. Immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) had the highest incidences, of 4. 6 pmp and 2. 6 pmp, respectively. Histologically non-examined PGDs represented over 50% of cases in Serbia, Bosnia and Herzegovina, and Romania and were also common in Greece, Estonia, Belgium and Sweden. The incidence declined from 18. 6 pmp in 2000 to 14. 5 pmp in 2013, after which it stabilized. All PGD subgroups had 5-year survival probabilities above 50%, with crescentic glomerulonephritis having the highest risk of death [adjusted hazard ratio 1. 8 (95% confidence interval 1. 6-1. 9)] compared with IgAN. Cardiovascular disease was the most common cause of death (33. 9%). The incidence of KRT for ESKD due to PGD showed large differences between countries and was highest and increasing for IgAN and FSGS. Lack of kidney biopsy facilities in some countries may have affected accurate assignment of the cause of ESKD. The recognition of the incidence and outcomes of KRT among different PGD subgroups may contribute to a more individualized patient care approach. OrderedDict([(u'fig', OrderedDict([(u'@position', u'float'), (u'@id', u'ga1'), (u'label', u'Graphical Abstract'), (u'graphic', OrderedDict([(u'@xlink:href', u'gfae034fig1g'), (u'@position', u'float')]))]))]).
Ajuts:	Comunidad de Madrid P2022/BMD-7223 Instituto de Salud Carlos III RD21/0005/0001 Instituto de Salud Carlos III RD21/0005/0016 European Commission PMP21/00 109 FEDER CA21165 COST 101 101 220 COST EU4H
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Dialysis ; Epidemiology ; Kidney replacement therapy ; Outcome ; Primary glomerular disease
Publicat a:	Nephrology Dialysis Transplantation, Vol. 39 (february 2024) , p. 1449-1460, ISSN 1460-2385

DOI: 10.1093/ndt/gfae034
PMID: 38327216

12 p, 1.5 MB

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