Speculative Review on the Feasibility of Porcine Circovirus 2 Elimination
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Sibila Vidal, Rosa Marina (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)

Data:	2025
Resum:	Porcine circovirus 2 (PCV2) is one of the main pathogens infecting swine. It can cause systemic and reproductive diseases and subclinical infections, and it has been associated with porcine dermatitis and nephropathy syndrome occurrence. Since its discovery during late 1990s, different scenarios have been experienced by swine producers over the world. The impact of a devastating disease with high mortality and lack of control tools was followed by the advent of highly efficacy vaccines. Despite having these products for around 20 years, PCV2 is still present worldwide. The present speculative review tackles those scientific aspects that may be considered for the eventual full elimination of PCV2 from pig farms. Porcine circovirus 2 (PCV2) is still infecting pigs after almost 20 years of massive vaccination all over the world. Vaccines are highly effective at counteracting the clinical signs of systemic disease caused by PCV2 and can significantly reduce the number of subclinically infected pigs. However, current vaccination programs based on one single dose in piglets are insufficient to prevent infection in a proportion of animals. Moreover, systematic vaccination of the herd changes viral epidemiology and, consequently, can cause modifications in infection timing. Such a scenario may prompt intrauterine and piglet early infections, thus facilitating viral circulation even before vaccination takes place. Considering the demonstrated high vaccine efficacy, it would be legitimate to explore the possibility of eliminating PCV2 from swine herds, but only one attempt to eliminate the virus from a herd has been published so far. The present speculative review evaluates the existing scientific literature regarding the feasibility of getting rid of this virus under commercial farm conditions. The use of PCV2 vaccination in all swine populations within a herd and the implementation of regional or national control programs are foreseen as compulsory for the eventual successful elimination of this endemic viral infection.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	porcine circovirus 2 (PCV2) ; Vaccine ; Elimination ; Eradication ; Whole-herd vaccination
Publicat a:	Animals, Vol. 15 (september 2025) , ISSN 2076-2615

DOI: 10.3390/ani15182744
PMID: 41007987

12 p, 437.0 KB

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