Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
Teles, Mariana (University of Aveiro. Department of Biology)
Oliveira, Miguel (University of Aveiro. Department of Biology)
Pacheco, M. Guilherme Garcês (University of Aveiro. Department of Biology)
Santos Maroño, Mauro (University of Aveiro. Department of Biology)

Date:	2005
Description:	6 pàg.
Abstract:	Anguilla anguilla L. were exposed during 24 and 48 h to 2. 7 μM β-naphthoflavone (BNF), a known microsomal enzyme inducer. The BNF effects on thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) and cortisol plasma levels were investigated. Alterations on plasma glucose and lactate levels were also measured as an indication of energy-mobilizing hormones alterations. BNF showed to be able to decrease significantly A. anguilla plasma T4 levels, whereas TSH, T3 and cortisol plasma remained constant. However, plasma glucose levels were significantly increased, demonstrating that intermediary metabolism has been affected. These results demonstrate that BNF a PAH-like compound alters the normal functioning of the hypothalamo-pituitary-thyroid (HPT) axis in A. anguilla.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Endocrine ; Plasma ; β-Naphthoflavone
Published in:	Environment International, Vol. 31, Num. 1 (January 2005) , p. 99-104, ISSN 1873-6750

DOI: 10.1016/j.envint.2004.07.003

Postprint 6 p, 343.4 KB

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