Incidence of tuberculosis infection among healthcare workers : Risk factors and 20-year evolution
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esteve, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Roldán Merino, Juan Francisco (Universitat de Barcelona)
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Garcia-Olivé, Ignasi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ruiz Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2013
Resum:	Objective: To determine the incidence of latent tuberculosis infection (LTBI), and risk factors for tuberculosis skin test (TST) conversion among Healthcare workers (HCWs) during a 20-year follow-up period. Design: Prospective cohort analysis. Surveillance was conducted from January 1, 1988, to December 31, 2007. SETTING: 600-bed tertiary referral hospital in Barcelona, Spain. Participants: HCWs in risk for occupational tuberculosis (TB) exposure, with negative baseline TST, direct contact with patients and/or biological samples and at least one follow-up visit with TST. Methods: TST is performed in HCWs with no previous history of TB or no previous positive TST. When TST is negative this test is performed once a year in high-risk workers, or at least every 2 years according to the hospital's guidelines. In all cases an interview questionnaire to gather information on possible risk factors was performed. Results: The study included 614 HCWs, 27% worked in areas of risk for TB exposure. Annual incidence rate had decreased from 46. 8 per 100 person-years in 1990 to 1. 08 per 100 person-years in 2007. Cumulative incidence was higher in HCWs who work in high-risk areas (p = 0. 004) and in time periods from 1990 to 1995, and from 1996 to 2001 (p < 0. 0001). Cox regression model showed a hazard ratio of 1. 55 (CI 95%; 1. 05-2. 27) in high-risk workers, adjusted by gender, age and professional status. Conclusions: Incidence of LTBI among HCWs is high, although it decreased throughout the follow-up period. It is crucial to maintain surveillance programs in HCWs. © 2012 Elsevier Ltd. All rights reserved.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Publicat a:	Respiratory Medicine, Vol. 107, Num. 4 (April 2013) , p. 601-607, ISSN 1532-3064

DOI: 10.1016/j.rmed.2012.12.008

Postprint 24 p, 192.8 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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