A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis
Ben Halima, Hamdi (Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Lyon, France)
Zine, Nadia (Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Lyon, France)
Bausells Roige, Joan (Institute of Microelectronics of Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193 Barcelona, Spain)
Jaffrezic-Renault, Nicole (Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Lyon, France)
Errachid, Abdelhamid (Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Lyon, France)

Data:	2022
Resum:	Assessing cortisol levels in human bodies has become essential to diagnose heart failure (HF). In this work, we propose a salivary cortisol detection strategy as part of an easily integrable lab-on-a-chip for detection of HF biomarkers. Our developed capacitive immunosensor based on hafnium oxide (HfO)/silicon structure showed good linearity between increasing cortisol concentration and the charge-transfer resistance/capacitance. Moreover, the developed biosensor was demonstrated to be highly selective toward cortisol compared to other HF biomarkers such as tumor necrosis factor (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP). The precision of our developed biosensor was evaluated, and the difference between the determined cortisol concentration in saliva and its expected one is.
Ajuts:	European Union's Horizon 2020 research and innovation program, Project NMBP−13-2017 KardiaTool, ERA PerMed ERA-NET 768686 European Union's Horizon 2020 951887
Drets:	Aquesta url de drets no existeix a la base de dades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Heart failure ; Cortisol ; Electrochemical impedance spectroscopy ; Capacitance ; Hafnium oxide
Publicat a:	Micromachines, Vol. 13 (December 2022), art. 2235, ISSN 2072-666X

DOI: 10.3390/mi13122235
PMID: 36557534

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