Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort : Results From the DISCOvERIE Project
Midenfjord, Irina (University of Gothenburg)
Khadija, Mahrukh (University of Gothenburg)
Sundelin, Elias (University of Gothenburg)
Trindade, Inês A. (University of Gothenburg)
Tornblom, Hans (University of Gothenburg)
Santos, Javier (Vall d'Hebron Institut de Recerca (VHIR))
Lobo Álvarez, Beatriz (Vall d'Hebron Institut de Recerca (VHIR))
Mulder, Danique (Radboud University Medical Center (Nijmegen, Països Baixos))
Vasquez, Alejandro Arias (Radboud University Medical Center (Nijmegen, Països Baixos))
Ruesing, Georgy (Goethe University)
Reif, Andreas (Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (Frankfurt, Alemanya))
Aichholzer, Mareike (Goethe University)
Van Den Houte, Maaike (Katholieke Universiteit te Leuven (1970- ))
Van Oudenhove, Lukas (Katholieke Universiteit te Leuven (1970- ))
Matteucci, Maria Chiara (Università di Bologna)
Barbara, Giovanni (Università di Bologna)
Bosman, Michelle (Maastricht UMC)
Jonkers, Daisy (Maastricht UMC)
Ramos-Quiroga, Josep Antoni (Vall d'Hebron Institut de Recerca (VHIR))
Jekkel, Eva (Semmelweis University (Budapest, Hongria))
Bitter, István (Semmelweis University (Budapest, Hongria))
Pop, Andrei-Vasile ('Iuliu Hat)
Dumitrascu, Dan Lucian ('Iuliu Hatieganu' University of Medicine and Pharmacy (Cluj-Napoca, Romania))
Alonso Cotoner, Carmen (Vall d'Hebron Institut de Recerca (VHIR))
Rodríguez-Urrutia, Amanda (Vall d'Hebron Institut de Recerca (VHIR))
Simrén, Magnus (University of Gothenburg)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2025
Resum:	Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS. Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid conditions, disease controls, and healthy controls. The presence of comorbidities was assessed through the Mini International Neuropsychiatric Interview (MINI) for anxiety or depression or through diagnostic criteria for fibromyalgia or chronic fatigue syndrome. Validated questionnaires on IBS (IBS-SSS), depressive (PHQ-9), anxiety (GAD-7) and somatic symptom severity (PHQ-12), fibromyalgia symptoms (FIQ) and fatigue (MFI) were completed. In total, 842 participants were recruited between March 2021 and January 2023, of which 607 had IBS, 161 were disease controls and 74 were healthy controls. IBS, anxiety, depression, somatic symptoms and fatigue were more severe in IBS patients with comorbidities compared with IBS patients without comorbidities. The severity of the abovementioned symptoms all increased gradually with increasing number of comorbidities (all p.
Ajuts:	European Commission 848228
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Anxiety ; Chronic fatigue syndrome ; Depression ; Fibromyalgia ; Gastrointestinal symptoms ; IBS ; Irritable bowel syndrome ; Psychiatric diagnoses ; Symptom burden ; Symptom severity
Publicat a:	United European Gastroenterology journal, Vol. 14 (December 2025) , art. e70157, ISSN 2050-6414

DOI: 10.1002/ueg2.70157
PMID: 41442222

11 p, 1.2 MB

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