Characterization of thrombosis risk in ambulatory patients with cancer : Results of the observational, prospective, multicenter CARTAGO study
Trujillo-Santos, Javier (Hospital General Universitario Santa Lucía (Cartagena, Múrcia))
García-Escobar, Ignacio (Universidad de Toledo)
Salgado, Mercedes (Complejo Hospitalario Universitario de Ourense (Galícia))
Araújo, António (University of Porto)
Martínez de Castro, Eva (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Molina, Raquel (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Castellón-Rubio, Victoria E. (Complejo Hospitalario Torrecárdenas (Almeria))
Domènech, Pere (Hospital Universitari de Bellvitge)
Gallardo Díaz, Enrique (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Colomé, Esteve (Medical Affairs Department, LEO Pharma)
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Benítez Montañez, José Carlos (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Porta, Rut (Institut Català d'Oncologia (Barcelona))
Lobo-De-Mena, Míriam (Hospital General Universitario de Valencia)
Malheiro, Mariana (São Francisco Xavier Hospital)
Font, C. (Hospital Clínic i Provincial de Barcelona)
Brozos-Vázquez, Elena (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Garicano, Fernando (Hospital de Galdakao (Usansolo, Biscaia))
Sapena, Victor (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Costa, Ana-Lucia (Santa Maria Hospital, Lisboa Norte Hospital Centre (CHLN))
Albuquerque, Ana Cristina (Setúbal Hospital Centre)
Cerezuela, Pablo (Hospital Universitario Virgen de la Arrixaca (Múrcia))

Data:	2024
Resum:	Background: Venous thromboembolism (VTE) is one of the leading causes of death in patients with cancer. Currently, there is a need to develop an easily applicable risk model that can identify patients who will benefit from receiving primary thromboprophylaxis to reduce the incidence of VTE. Patients and methods: This was a non-interventional, multicenter, observational, prospective study carried out in 62 Oncology and Hematology services in Spain and Portugal between January 2018 and December 2019. The main objective of the CARTAGO study was to develop a predictive model within a competitive risk framework to assess the risk of VTE in patients with cancer undergoing chemotherapy, biological, or hormonal treatment. Results: A total of 1596 patients were analyzed. VTE events occurred in 124 (8%) during the 6-month follow-up period (42% of deep vein thrombosis [DVT], 48% of pulmonary embolism [PE], and 10% of both DVT and PE). Four variables were selected for the multivariate predictive model to determine the risk of VTE (tumor type, D-dimer, compression of a vessel by the tumor, and leukocyte count). The 4 variables were associated with an increased risk of VTE (C-statistic, 0. 646 [95%CI, 0. 620-0. 673]). The most significant variables in the internal validation with bootstrapping were the "very high risk"tumors (hazard ratio [HR] 2. 032; 95%CI, 1. 287-3. 211). Conclusion: The CARTAGO model predicts the VTE risk in patients with cancer receiving anticancer therapy in an outpatient setting. This model can easily aid in identifying ambulatory patients who would probably benefit from primary thromboprophylaxis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	D-dimer ; Leukocytes ; Thromboprophylaxis ; Venous thromboembolism ; Cancer
Publicat a:	The Oncologist, Vol. 30, Num. 8 (December 2024) , art. oyae334, ISSN 1549-490X

DOI: 10.1093/oncolo/oyae334
PMID: 39673414

11 p, 959.8 KB

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