Characteristics of Patients with Heart Failure and Advanced Chronic Kidney Disease (Stages 4-5) Not Undergoing Renal Replacement Therapy (ERCA-IC Study)
Valdivielso Moré, Sandra (Universitat Autònoma de Barcelona)
Vicente Elcano, Miren (Hospital del Mar (Barcelona, Catalunya))
Garcia Alonso, Anna (Hospital del Mar (Barcelona, Catalunya))
Pascual Sanchez, Sergi (Hospital del Mar (Barcelona, Catalunya))
Galceran Herrera, Isabel (Hospital del Mar (Barcelona, Catalunya))
Barbosa, Francesc (Hospital del Mar (Barcelona, Catalunya))
Belarte Tornero, Laia Carla (Hospital del Mar (Barcelona, Catalunya))
Ruiz Bustillo, Sonia (Hospital del Mar (Barcelona, Catalunya))
Morales, Ronald O. (Hospital del Mar (Barcelona, Catalunya))
Barrios, Clara (Hospital del Mar (Barcelona, Catalunya))
Vime Jubany, Joan (Hospital del Mar (Barcelona, Catalunya))
Farré, Núria (Hospital del Mar (Barcelona, Catalunya))

Data:	2023
Resum:	Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Results: Forty percent of patients had a history of HF. The mean age was 78. 2 ± 8. 8 years and the mean eGFR was 18. 4 ± 5. 5 mL/min/1. 73 m. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66. 7% vs. 53. 1%, HR 95% CI 1. 62 (1. 04-2. 52), p = 0. 034). No differences were found in the need for RRT (27. 6% vs. 32. 2%, p = 0. 46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36. 8 vs. 19. 8%, p = 0. 1). Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Advanced chronic kidney disease ; Cardiorenal ; Heart failure ; Kidney dysfunction ; Prognosis
Publicat a:	Journal of clinical medicine, Vol. 12, Num. 6 (March 2023) , art. 2339, ISSN 2077-0383

DOI: 10.3390/jcm12062339

9 p, 546.7 KB

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