Consolidation deficits in episodic memory define distinct clinical and neurodegenerative profiles in Huntington's disease
Martínez-Horta, Saul (Institut de Recerca Sant Pau)
Quevedo-García, Angela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Puig-Davi, Arnau (Institut de Recerca Sant Pau)
Sampedro, Frederic (Institut de Recerca Sant Pau)
Oltra-Cucarella, Javier (Universidad Miguel Hernández de Elche)
Pérez-Pérez, Jesús (Institut de Recerca Sant Pau)
Franch-Martí, Carla (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Olmedo-Saura, Gonzalo (Institut de Recerca Sant Pau)
Rivas Asensio, Elisa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vazquez-Oliver, Anna (Institut de Recerca Sant Pau)
Pérez-Carasol, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Horta-Barba, Andrea (Institut de Recerca Sant Pau)
Pagonabarraga Mora, Javier (Institut de Recerca Sant Pau)
Kulisevsky, Jaime (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Departament de medicina

Data:	2025
Resum:	Background: Huntington's disease (HD) is primarily associated with executive dysfunction, but episodic memory impairment is also present. Traditionally, these memory deficits have been attributed to retrieval difficulties linked to fronto-striatal dysfunction, rather than to disruptions in encoding or consolidation processes. However, the specific nature and diversity of memory impairments in HD remain underexplored. Objective: To characterize the profile of episodic memory impairment in HD, identify distinct cognitive phenotypes, and examine their clinical, neuroanatomical, and biomarker correlates. Methods: We assessed episodic memory in HD patients and healthy controls using the Free and Cued Selective Reminding Test (FCSRT), complemented by Item-Specific Deficit Approach (ISDA) indices to quantify encoding, consolidation, and retrieval deficits. Structural MRI was used to identify gray matter volume correlates, and plasma neurofilament light chain (NfL) was measured as a marker of neuroaxonal injury. Results: Compared to controls, HD patients showed marked impairments in free recall with preserved cued recall, suggesting predominant retrieval deficits. However, nearly one-third of patients exhibited global impairments across all FCSRT components, mainly driven by consolidation deficits consistent with medial temporal lobe dysfunction. This subgroup also showed worse cognitive and functional performance and significant atrophy in the hippocampus, entorhinal cortex, and parahippocampal gyrus.
Ajuts:	Instituto de Salud Carlos III PI21/01758
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Huntington's disease ; Neuropsychology ; Episodic memory ; Hippocampus ; MRI
Publicat a:	NeuroImage. Clinical, Vol. 48 (October 2025) , art. 103894, ISSN 2213-1582

DOI: 10.1016/j.nicl.2025.103894
PMID: 41172859

11 p, 4.6 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats