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| Home > Articles > Published articles > Association between dietary niacin intake and diabetic retinopathy in a Catalonian population : |
(Universitat Autònoma de Barcelona) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) (Universitat de Barcelona) (Universitat Autònoma de Barcelona. Departament de medicina) (Washington University School of Medicine) (Universitat de Lleida) (Avantmedic Center) (Hospital Arnau de Vilanova (Lleida, Catalunya)) (Institut de Recerca Sant Pau) (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau)
| Date: | 2025 |
| Abstract: | Background: Accumulating evidence suggests that niacin interventions may have a beneficial role in preventing ophthalmological microangiopathic remodeling. This study aimed to assess the impact of niacin intake on the presence of diabetic retinopathy (DR) in two independent Mediterranean cohorts of individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods: Cross-sectional, population-based epidemiologic study. A total of 243 individuals with T1D, and 291 individuals with T2D. All participants underwent an eye examination. Dietary niacin intake was analyzed using a validated Spanish 101-items food frequency questionnaire consumption. The association between niacin intake and DR was assessed using a multivariate logistic regression, with potential non-linear associations further explored through restricted cubic spline regression. DR diagnostic was established via multifield stereoscopic retinal photography, in accordance with the international consensus on DR. Results: DR was identified in 103 out of 243 individuals with T1D and 144 out of 291 with T2D. Dietary niacin intake did not differ within the study groups according to DR status. Multivariate logistic regression models also revealed no association between dietary niacin intake and DR. As previously described, the duration of diabetes for T1D and T2D, [OR (95%CI), 1. 02 (1. 01-1. 03), and 1. 02 (1. 02-1. 03), respectively] and glycated hemoglobin (HbA1c) [OR (95%CI), 1. 16 (1. 09-1. 24), and 1. 14 (1. 09-1. 18), respectively] were identified as the main determinant variables for DR in both groups. Conclusions: We found that dietary niacin intake was not associated with the presence of RD in subjects with either T1D or T2D. Further research is needed to better understand the potential role of niacin in the development or prevention of DR. |
| Grants: | Instituto de Salud Carlos III PI21/00770 Instituto de Salud Carlos III PI24/00156 Instituto de Salud Carlos III PI15/0625 Instituto de Salud Carlos III PI18/0328 Instituto de Salud Carlos III PI12/0183 Ministerio de Economía y Competitividad CB15/00071 Ministerio de Sanidad y Consumo CB06/03/0017 Generalitat de Catalunya 2021/SGR-01211 Generalitat de Catalunya 2021/SGR-00857 Generalitat de Catalunya 2021/SGR-01149 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Retinopathy ; Diabetes ; Vitamin B3 ; Niacin ; Neuropathy ; Microangiopathy ; Tryptophan |
| Published in: | Frontiers in nutrition, Vol. 12 (October 2025) , art. 1626379, ISSN 2296-861X |
