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Barriers to Deprescribing Benzodiazepines in Older Adults in a Survey of European Physicians
Salvà Casanovas, Antonio (Universitat Autònoma de Barcelona. Fundació Salut i Envelliment UAB)
Miralles Basseda, Ramon (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Shapoval, Vladyslav (Université catholique de Louvain (UCLouvain))
de Saint Hubert, Marie (Institute of Health and Society (IRSS). UCLouvain)
Evrard, Perrine (Université catholique de Louvain (UCLouvain))
Sibille, François Xavier (Institute of Health and Society (IRSS). UCLouvain)
Aubert, Carole E. (University of Bern)
Bolt, Lucy (University of Bern)
Tsoutsi, Vagioula (National & Kapodistrian University of Athens)
Kollia, Pinelopi (National & Kapodistrian University of Athens)
Wichniak, Adam (Third Department of Psychiatry. Institute of Psychiatry and Neurology)
Gustavsson, Katarzyna (Department of Science and Evaluation. Medical Research Agency)
Wyller, Torgeir Bruun (University of Oslo)
Callegari, Enrico (Østfold Hospital Trust (Noruega))
Grimshaw, Jeremy M. (University of Ottawa)
Presseau, Justin (University of Ottawa)
Henrard, Séverine (Institute of Health and Society (IRSS). UCLouvain)
Spinewine, Anne (CHU UCLouvain Namur)

Date: 2025
Abstract: IMPORTANCE The use of benzodiazepine receptor agonists (BZRA) poses serious health risks to older adults. Although several guidelines recommend deprescribing, implementation in clinical practice remains limited. OBJECTIVE To identify physicians' barriers to and enablers of deprescribing BZRA in adults aged 65 years and older taking a BZRA for sleep problems; to determine factors associated with hospital physicians' intention to deprescribe BZRA and their self-reported routine BZRA deprescribing. DESIGN, SETTING, AND PARTICIPANTS This survey study included hospital physicians and general practitioners (GPs) working across 6 European Countries (Belgium, Greece, Norway, Poland, Spain, and Switzerland) between December 2022 and March 2023. MAIN OUTCOMES AND MEASURES Barriers identification via a 35-item questionnaire based upon the Theoretical Domains Framework (TDF). Responses were categorized as major barriers, moderate barriers, and enablers based on their mean scores. Multivariable logistic regressions were used to identify background characteristics and TDF-based domains associated with hospital physicians' intention to deprescribe and self-reported routine deprescribing. RESULTS Questionnaires from 240 hospital physicians and 96 GPs were analyzed. Most participants were women: 144 (61. 0%) hospital physicians and 52 (54. 2%) GPs. In terms of experience, the most common reported time in practice was less than 5 years for hospital physicians (76 [31. 7%]) and between 10 and 14 years for GPs (35 [36. 5%]). Most reported deprescribing BZRA routinely (135 hospital physicians [57. 2%] and 66 GPs [72. 5%]). Major barriers (and TDF domains) were similar for hospital physicians and GPs across the 6 countries. These barriers included: lack of training (skills), low self-efficacy (beliefs about capabilities), prioritization of other health issues (goals), frustration with the challenges of deprescribing (emotions), insufficient staff and time, absence of local policies (environmental context and resources), and reluctance from patients (social influence). Intention to deprescribe was significantly associated with country, occupation type, and 5 TDF domains: memory, attention, and decision process (odds ratio [OR], 1. 70; 95% Ci, 1. 22-2. 40); social and/or professional role and identity (OR, 5. 92; 95% CI, 3. 28-11. 07); beliefs about capabilities (OR, 2. 35; 95% CI, 1. 55-3. 63); beliefs about consequences (OR, 3. 00; 95% CI, 1. 61-5. 71); and reinforcement (OR, 1. 49; 95% CI, 1. 05-2. 15). Routine deprescribing was significantly associated with 3 TDF domains: memory, attention, and decision processes; intentions; and emotions. CONCLUSION In this theory-based survey study of physicians, physicians and general practitioners described numerous barriers to deprescribing BZRA in older adults. Our findings indicate that effective deprescribing efforts require approaches that address both reflective processes (eg, enhancing capability) and impulsive processes (eg, managing emotions).
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Aged ; Attitude of Health Personnel ; Benzodiazepines ; Deprescriptions ; Europe ; Female ; Humans ; Male ; Middle Aged ; Physicians ; Practice Patterns, Physicians' ; Surveys and Questionnaires
Published in: JAMA network open, Vol. 8, Num. 3 (2025) , art. e2459883, ISSN 2574-3805

DOI: 10.1001/jamanetworkopen.2024.59883
PMID: 40029661


14 p, 916.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Fundació Salut i Envelliment UAB
Articles > Research articles
Articles > Published articles

 Record created 2026-04-08, last modified 2026-04-21



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