Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients
Sanz-Sanz, Jesús (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Gutiérrez Casbas, Ana (Hospital General Universitario de Dr. Balmis de Alicante Servicio Digestivo)
Plaza, Zulema (Sociedad Española de Reumatología (Madrid))
Gratacós, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Rodríguez-Lago, Iago (Departamento de Gastroenterología, Hospital Universitario Galdakao-Usansolo, Instituto de Investigación Sanitaria Biobizkaia, 48960 Galdakao, Spain)
Marín-Jiménez, Ignacio (Hospital General Universitario Gregorio Marañón)
Trujillo-Martín, Elisa (Hospital Universitario de Canarias (La Laguna))
Pérez-Pampín, Eva (Complejo Hospitalario Universitario de Santiago de Compostela)
Barreiro de-Acosta, Manuel (Complejo Hospitalario Universitario de Santiago de Compostela)
Hernández-Hernández, María Vanesa (Complejo Hospitalario Universitario de Santiago de Compostela)
Carrillo-Palau, Marta (Hospital Universitario de Canarias (La Laguna))
García Vivar, María Luz (Hospital Universitario de Basurto (Bilbao, Biscaia))
Muñoz-Villafranca, María Carmen (Hospital Universitario de Basurto (Bilbao, Biscaia))
Ladehesa-Pineda, Maria Lourdes (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Iglesias-Flores, Eva (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Merino-Argumánez, Carolina (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
González-Lama, Yago (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Arévalo Salaet, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Calvet, Xavier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Díaz-González, Federico (Hospital Universitario de Canarias (La Laguna))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Background/Objectives : The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we examined fecal calprotectin (FC) levels in relation to the accuracy of IBD diagnosis. Methods : EISER was a cross-sectional, multicenter, observational, rheumatologist-gastroenterologist collaborative study. Patients with SpA naïve to biologics were recruited. Demographic and clinical characteristics, disease activity, and treatment information were collected. Patients with FC ≥ 80 µg/g or IBD-related symptoms underwent a colonoscopy or video capsule endoscopy. Receiver operating characteristic analysis assessed the predictive value of FC for IBD diagnosis. Results : Of the 570 patients recruited, 494 were evaluable for the main outcome, 248 (50. 2%) had axSpA, and 246 (49. 8%) had PsA. Overall, 28/494 patients were diagnosed with IBD (5. 7%, 95%CI 3. 6-7. 7). Sorted by clinical entity, 22 (8. 9%, 95%CI 5. 3-12. 4) axSpA and 6 (2. 4%, 95%CI 0. 5-4. 4) PsA patients had a diagnosis of IBD: 24 (86%, 95%CI 79. 4-92. 6) had ileal/ileocolonic Crohn's disease (CD), 3 (11%, 95%CI 5. 1-16. 9) unclassified IBD, and 1 (3. 5%, 95%CI 0. 0-6. 9) ulcerative colitis. The ROC curve for FC and IBD diagnosis (AUC: 0. 870, p.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Prevalence undiagnostic ; Inflammatory bowel disease ; Fecal calprotectin ; Axial spondylarthritis ; Psoriatic arthritis
Published in:	Journal of clinical medicine, Vol. 14 (June 2025) , art. 4569, ISSN 2077-0383

DOI: 10.3390/jcm14134569
PMID: 40648945

14 p, 563.4 KB

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