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Articles 23 registres trobats  anterior11 - 20següent  anar al registre: La cerca s'ha fet en 0.00 segons. 
11.
28 p, 6.3 MB PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells / Georgilis, Athena (Imperial College London) ; Klotz, Sabrina (Eberhard Karls University Tübingen) ; Hanley, Christopher J. (University of Southampton) ; Herranz, Nicolas (Imperial College London) ; Weirich, Benedikt (German Cancer Research Centre (DKFZ)) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Leote, Ana Carolina (Universidade de Lisboa) ; D'Artista, Luana (Eberhard Karls University Tübingen) ; Gallage, Suchira (German Cancer Research Centre (DKFZ)) ; Seehawer, Marco (Eberhard Karls University Tübingen) ; Carroll, Thomas (Imperial College London) ; Dharmalingam, Gopuraja (Imperial College London) ; Wee, Keng Boon (Bioinformatics Institute) ; Mellone, Marco (University of Southampton) ; Pombo, Joaquim (Imperial College London) ; Heide, Danijela (German Cancer Research Centre (DKFZ)) ; Guccione, Ernesto (Institute of Molecular and Cell Biology (Singapore)) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Barbosa-Morais, Nuno L. (Universidade de Lisboa) ; Heikenwälder, Mathias (German Cancer Research Centre (DKFZ)) ; Thomas, Gareth J. (University of Southampton) ; Zender, Lars (German Cancer Research Center (DKFZ)) ; Gil, Jesús (Imperial College London)
Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. [...]
2018 - 10.1016/j.ccell.2018.06.007
Cancer Cell, Vol. 34 (july 2018) , p. 85-102.e9  
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12.
18 p, 3.6 MB hnRNPDL phase separation is regulated by alternative splicing and disease-causing mutations accelerate its aggregation / Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yang, Peiguo (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Coughlin, Maura (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Messing, James (Howard Hughes Medical Institute) ; Pesarrodona Roches, Mireia (Institut de Recerca Biomèdica de Lleida) ; Szulc, Elzbieta (Institut de Recerca Biomèdica de Lleida) ; Salvatella, Xavier (Institut de Recerca Biomèdica de Lleida) ; Kim, Hong Joo (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Taylor, J. Paul (Howard Hughes Medical Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. [...]
2020 - 10.1016/j.celrep.2019.12.080
Cell reports, Vol. 30, issue 4 (Jan. 2020) , p. 1117-1128  
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13.
12 p, 1.3 MB Regulation of TSHR expression in the thyroid and thymus may contribute to TSHR tolerance failure in graves' disease patients via two distinct mechanisms / Marín-Sánchez, Ana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Álvarez de la Sierra, Daniel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; González López, Óscar 1969- (Hospital Universitari Vall d'Hebron) ; Lucas Martín, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sellés-Sánchez, Alicia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rudilla, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Enrich, E. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pujol-Borrell, Ricardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. While failure of TSHR tolerance is central to GD pathogenesis, the process leading to this failure remains poorly understood. [...]
2019 - 10.3389/fimmu.2019.01695
Frontiers in immunology, Vol. 10 (July 2019) , art. 1695  
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14.
27 p, 2.2 MB Novel polyomaviruses in mammals from multiple orders and reassessment of polyomavirus evolution and taxonomy / Ehlers, Bernhard (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Anoh, A. E. (Université Alassane Ouattara. Centre de Recherche pour le Développement) ; Salem, N. B. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Broll, S. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Couacy-Hymann, E. (Laboratoire National d'Appui Au Développement Agricole. Laboratoire Central de Pathologie Animale) ; Fischer, D. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Gedvilaite, A. (Institute of Biotechnology. Vilnius University) ; Ingenhütt, N. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Liebmann, S. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Martin, Maite (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Mossoun, A. (Laboratoire National d'Appui Au Développement Agricole. Laboratoire Central de Pathologie Animale) ; Mugisha, L. (Makerere University. College of Veterinary Medicine. Animal Resources and Biosecurity (COVAB)) ; Muyembe-Tamfum, J. J. (Institut National de Recherche Bio-Médicale) ; Pauly, M. (Robert Koch Institute. Epidemiology of Highly Pathogenic Microorganisms) ; De Val, B. P. (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Preugschas, H. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Richter, D. (Technische Universität Braunschweig) ; Schubert, G. (Robert Koch Institute. Epidemiology of Highly Pathogenic Microorganisms) ; Szentiks, C. A. (Leibniz Institute for Zoo and Wildlife Research (IZW)) ; Teichmann, T. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Walter, C. (Robert Koch Institute. Division 12 Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients) ; Ulrich, R. G. (Partner Site Hamburg-Lübeck-Borstel-Insel Riems. German Center for Infection Research (DZIF)) ; Wiersma, L. (Robert Koch Institute. Epidemiology of Highly Pathogenic Microorganisms) ; Leendertz, F. H. (Robert Koch Institute. Epidemiology of Highly Pathogenic Microorganisms) ; Calvignac-Spencer, S. (Robert Koch Institute. Viral Evolution)
As the phylogenetic organization of mammalian polyomaviruses is complex and currently incompletely resolved, we aimed at a deeper insight into their evolution by identifying polyomaviruses in host orders and families that have either rarely or not been studied. [...]
2019 - 10.3390/v11100930
Viruses, Vol. 11 Núm. 10 (october 2019) , p. 930  
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15.
12 p, 1.0 MB Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors / Huertas, César S. (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Escuela, Alfonso M. (Universidad de Las Palmas de Gran Canaria) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteomes by the alternative selection of exonic sequences. Alterations in this mechanism are associated with most cancers, enhancing their proliferation and survival, and can be employed as cancer biomarkers. [...]
2019 - 10.1021/acs.analchem.9b03898
Analytical chemistry, Vol. 91, Issue 23 (December 2019) , p. 15138-15146  
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16.
32 p, 1.1 MB Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing / Huertas, César S. (Institut Català de Nanociència i Nanotecnologia) ; Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. [...]
2016 - 10.1016/j.bios.2015.11.023
Biosensors & bioelectronics, Vol. 78 (April 2016) , p. 118-125  
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17.
8 p, 985.7 KB Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor / Huertas, César S. (Institut Català de Nanociència i Nanotecnologia) ; Domínguez Zotes, Santos (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. [...]
2017 - 10.1038/srep41368
Scientific reports, Vol. 7 (January 2017) , art. 41368  
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18.
21 p, 6.7 MB Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM) / Coccia, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Calleja Yagüe, Isabel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Planells Ferrer, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sanuy, Blanca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sanz, Belen (Centro Nacional de Investigaciones Oncológicas) ; López-Soriano, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Moubarak, Rana S. (Department of Pathology. NYU Langone Medical Center) ; Munell Casadesus, Francina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barneda Zahonero, Bruna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Comella i Carnicé, Joan Xavier 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pérez-García, M. Jose (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Fas Apoptosis Inhibitory Molecule (FAIM) is an evolutionarily highly conserved death receptor antagonist, widely expressed and known to participate in physiological and pathological processes. Two FAIM transcript variants have been characterized to date, namely FAIM short (FAIM-S) and FAIM long (FAIM-L). [...]
2017 - 10.1371/journal.pone.0185327
PloS one, Vol. 12 Núm. 10 (october 2017) , p. e0185327  
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19.
12 p, 786.7 KB Differential expression of mRNA isoforms in the skeletal muscle of pigs with distinct growth and fatness profiles / Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica) ; Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ; Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ; González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ; Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Cánovas, Angela (University of Guelph. Department of Animal Biosciences)
Background: the identification of genes differentially expressed in the skeletal muscle of pigs displaying distinct growth and fatness profiles might contribute to identify the genetic factors that influence the phenotypic variation of such traits. [...]
2018 - 10.1186/s12864-018-4515-2
BMC genomics, Vol. 19 (2018) , art. 145  
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20.
13 p, 2.4 MB Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461 / Li, Guihong (Zhengzhou, 450000 China) ; Shen, Jing (Department of Cardiology, Shengze Hospital of Jiangsu Province, Suzhou, 215200 China) ; Cao, Junguo (Changchun, 130021 China) ; Zhou, Guangtong (Zhengzhou, 450000 China) ; Lei, Ting (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sun, Yuxue (Changchun, 130021 China) ; Gao, Haijun (Changchun, 130021 China) ; Ding, Yaonan (Changchun, 130021 China) ; Xu, Weidong (Changchun, 130021 China) ; Zhan, Zhixin (Changchun, 130021 China) ; Chen, Yong (Changchun, 130021 China) ; Huang, Haiyan (Changchun, 130021 China) ; Universitat Autònoma de Barcelona
Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in the presence of multiple transcripts in various tumor systems. [...]
2018 - 10.1186/s13046-018-0749-8
Journal of Experimental & Clinical Cancer Research : CR, Vol. 37 (april 2018)  
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Articles : 23 registres trobats   anterior11 - 20següent  anar al registre:
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