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Articles 22 registres trobats  inicianterior13 - 22  anar al registre: La cerca s'ha fet en 0.00 segons. 
13.
11 p, 4.3 MB Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1 G93A mice / Martínez Muriana, Anna (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pastor, Diego (UMH-CSIC. Instituto de Neurociencias) ; Mancuso, Renzo (KU Leuven. VIB Center for Brain and Disease Research) ; Rando, Amaya (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ; Osta, Rosario (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ; Martínez, Salvador (UMH-CSIC. Instituto de Neurociencias) ; López Vales, Rubèn (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Facultat de Medicina)
The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peripheral nervous system in a murine model of ALS. [...]
2020 - 10.1186/s13287-020-1573-6
Stem cell research & therapy, Vol. 11 (february 2020)  
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14.
10 p, 2.3 MB OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis / Sánchez Fernández, Alba (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Skouras, Damaris B. (Olatec Therapeutics LLC) ; Dinarello, Charles A. (Department of Medicine. Radboud University Medical Center) ; López Vales, Rubèn (Universitat Autònoma de Barcelona. Institut de Neurociències)
IL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including multiple sclerosis (MS). [...]
2019 - 10.3389/fimmu.2019.02578
Frontiers in immunology, Vol. 10 (january 2019) , p. 2578  
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15.
49 p, 575.7 KB Myeloid cell responses after spinal cord injury / David, Samuel (Centre for Research in Neuroscience. The Research Institute of the McGill University Health Center) ; Kroner, A. (Clement J. Zablocki Veterans Affairs Medical Center. Department of Neurosurgery. Medical College of Wisconsin) ; Greenhalgh, A. D. (Laboratory of Nutrition and Integrated Neurobiology. INRA. University of Bordeaux) ; Zarruk, J. G. (Centre for Research in Neuroscience. The Research Institute of the McGill University Health Center) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
2018 - 10.1016/j.jneuroim.2018.06.003
Journal of Neuroimmunology, Vol. 321 (Aug. 2018) , p. 97-108  
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16.
32 p, 2.8 MB Beneficial effects of IL-37 after spinal cord injury in mice / Coll Miró, Marina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Torres Espín, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bufler, P. (Ludwig-Maximilians-Universität München) ; Dinarello, CA. (Radboud University Medical Center. Department of Medicine) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend to the central nervous system remains unknown, however. [...]
2016 - 10.1073/pnas.1523212113
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, issue 5 (2016) , p. 1411-1416  
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17.
13 p, 3.3 MB Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after Spinal Cord Injury / Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gronert, Karsten (University of California (Berkeley)) ; Sullivan, Aaron B. (University of California (Berkeley)) ; Kopp, Marcel A. (Charité - Universitätsmedizin Berlin) ; Brommer, Benedikt (Charité - Universitätsmedizin Berlin) ; David, Samuel (McGill University Health Centre (Montreal, Canadà)) ; Schwab, Jan M. (Charité - Universitätsmedizin Berlin) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodeling and leads to functional deficits. Effective pharmacological treatments for SCI are not currently available. [...]
2017 - 10.1523/JNEUROSCI.1395-17.2017
The Journal of neuroscience, Vol. 37, Núm. 48 (November 2017) , p. 11731-11743  
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18.
30 p, 219.1 KB IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury / Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Amo Aparicio, Jesús (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martínez Muriana, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Macrophages and microglia play a key role in the maintenance of nervous system homeostasis. However, upon different challenges, they can adopt several phenotypes, which may lead to divergent effects on tissue repair. [...]
2016 - 10.1002/glia.23041
GLIA, Vol. 64 Núm. 12 (2016) , p. 2079-2092
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19.
13 p, 2.2 MB CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves / Martínez Muriana, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Olmos Alonso, Adrian (University of Southampton. Centre for Biological Sciences) ; Osta, Rosario (Universidad de Zaragoza) ; Perry, V. Hugh (University of Southampton. Centre for Biological Sciences) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gomez-Nicola, Diego (University of Southampton. Centre for Biological Sciences) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inflammation is a common neuropathological feature in several neurological disorders, including amyotrophic lateral sclerosis (ALS). We have studied the contribution of CSF1R signalling to inflammation in ALS, as a pathway previously reported to control the expansion and activation of microglial cells. [...]
2016 - 10.1038/srep25663
Scientific reports, Vol. 6 (May 2016) , article 25663  
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20.
15 p, 2.1 MB CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype / Peluffo, Hugo (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica) ; Solari-Saquieres, Patricia (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica) ; Negro-Demontel, María Luciana (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica) ; Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lago, Natalia (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica)
Background: It has recently become evident that activating/inhibitory cell surface immune receptors play a critical role in regulating immune and inflammatory processes in the central nervous system (CNS). [...]
2015 - 10.1186/s12974-015-0364-y
Journal of neuroinflammation, Vol. 12, No. 145 (2015)  
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21.
12 p, 3.5 MB Activation of lysophosphatidic acid receptor type 1 (LPA1) contributes to pathophysiology of spinal cord injury / Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Serrano, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hernández Martín, Joaquim (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lago, Natalia (Institut Pasteur de Montevideo. Laboratorio de Neuroinflamación y Terapia Génica) ; Astudillo, Alma M. (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Biología y Genética Molecular) ; Balsinde, Jesús (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Biología y Genética Molecular) ; Estivill-Torrus, Guillermo (Instituto de Investigación Biomédica de Málaga) ; Rodríguez de Fonseca, Fernando (Instituto de Investigación Biomédica de Málaga) ; Chun, Jerold (Scripps Research Institute. Dorris Neuroscience Center) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions that signals through six known G-protein-coupled receptors (LPA1-LPA6). A wide range of LPA effects have been identified in the CNS, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and development of neuropathic pain. [...]
2015 - 10.1523/JNEUROSCI.4703-14.2015
The Journal of neuroscience, Vol. 35, Num. 28 (2015) , p. 10224-10235  
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22.
11 p, 4.1 MB Beneficial effects of αB-crystallin in spinal cord contusion injury / Klopstein, Armelle (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Redensek, Adriana (McGill University Health Centre. Center for Research in Neuroscience) ; David, Samuel (McGill University Health Centre. Center for Research in Neuroscience) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
αB-crystallin is a member of the heat shock protein family that exerts cell protection under several stress-related conditions. Recent studies have revealed that αB-crystallin plays a beneficial role in a mouse model of multiple sclerosis, brain ischemia, and Alexander disease. [...]
2012 - 10.1523/JNEUROSCI.0923-12.2012
The Journal of neuroscience, Vol. 32 No. 42 (October 2012) , p. 14478-14488  
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Articles : 22 registres trobats   inicianterior13 - 22  anar al registre:
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2 Lopez-Vales, Ruben
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