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Articles 24 records found  previous11 - 20next  jump to record: Search took 0.00 seconds. 
11.
44 p, 8.3 MB A multiscale model of complex endothelial cell dynamics in early angiogenesis / Stepanova, Daria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Byrne, Helen (University of Oxford) ; Maini, Philip K. (University of Oxford) ; Alarcón Cor, Tomás (Barcelona Graduate School of Mathematics (BGSMath))
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by which endothelial cells (ECs) migrate from a pre-existing vascular bed in response to local environmental cues and cell-cell interactions, to create a new vascular network. [...]
2021 - 10.1371/journal.pcbi.1008055
PLoS computational biology, Vol. 17, Num. 1 (January 2021) , art. e1008055  
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12.
21 p, 2.1 MB The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells : a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes / Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Gumuzio, Juan (StemTek Therapeutics (Bilbao)) ; Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ; Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ; Bosch-Barrera, J (Universitat de Girona. Departament de Medicina) ; Martin-Castillo, Begoña (Institut Català d'Oncologia) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Encinar, José Antonio (Universidad Miguel Hernández de Elche. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche) ; Martin, Ángel G. (StemTek Therapeutics (Bilbao)) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona)
SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). [...]
2020 - 10.18632/aging.102887
Aging (Albany NY), Vol. 12, Issue 6 (March 2020) , p. 4794-4814  
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13.
11 p, 2.0 MB In silico clinical trials for anti-aging therapies / Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Folguera Blasco, Núria (The Francis Crick Institute. Quantitative Cell Biology Lab) ; Verdura, Sara (Institut d'Investigació Biomèdica de Girona) ; Martin-Castillo, Begoña (Institut Català d'Oncologia) ; Joven, Jorge (Institut d'Investigació Sanitària Pere Virgili) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Therapeutic strategies targeting the hallmarks of aging can be broadly grouped into four categories, namely systemic (blood) factors, metabolic manipulation (diet regimens and dietary restriction mimetics), suppression of cellular senescence (senolytics), and cellular reprogramming, which likely have common characteristics and mechanisms of action. [...]
2019 - 10.18632/aging.102180
Aging (Albany NY), Vol. 11, Issue 16 (August 2019) , p. 6591-6601  
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14.
6 p, 3.0 MB Minimum action path theory reveals the details of stochastic transitions out of oscillatory states / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics (UK)) ; Guerrero, Pilar (University College London. Department of Mathematics (UK)) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Page, Karen M. (University College London. Department of Mathematics (UK)) ; Centre de Recerca Matemàtica
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Transitions between such states are studied as noise-driven escape problems in the chemical species space. Escape can occur via multiple possible multidimensional paths, with probabilities depending nonlocally on the noise. [...]
2018 - 10.1103/PhysRevLett.120.128102
Physical review letters, Vol. 120, Issue 12 (March 2018) , art. 128102  
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15.
27 p, 3.0 MB A multiscale model of epigenetic heterogeneity-driven cell fate decision-making / Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592  
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16.
2 p, 566.7 KB De la Cruz et al. Reply / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics) ; Guerrero, Pilar (University College London. Department of Mathematics) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Page, Karen M. (University College London. Department of Mathematics)
2019 - 10.1103/PhysRevLett.122.059802
Physical review letters, Vol. 122, Issue 5 (February 2019) , art. 059802  
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17.
18 p, 918.2 KB Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth / Cruz Moreno, Roberto de la, (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Guerrero, Pilar (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Calvo, Juan (Universidad de Granada. Departamento de Matemática Aplicada) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
The development of hybrid methodologies is of current interest in both multi-scale modelling and stochastic reaction-diffusion systems regarding their applications to biology. We formulate a hybrid method for stochastic multi-scale models of cells populations that extends the remit of existing hybrid methods for reaction-diffusion systems. [...]
2017 - 10.1016/j.jcp.2017.09.019
Journal of computational physics, Vol. 350 (Dec. 2017) , p. 974-991  
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18.
23 p, 2.3 MB Stochastic multi-scale models of competition within heterogeneous cellular populations : Simulation methods and mean-field analysis / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Guerrero, Pilar (University College London. Department of Mathematics) ; Spill, Fabian (Boston University. Department of Biomedical Engineering) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated proliferation rate. [...]
2016 - 10.1016/j.jtbi.2016.07.028
Journal of theoretical biology, Vol. 407 (Oct. 2016) , p. 161-183  
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19.
19 p, 13.4 MB Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis : evidence for metformin-based "starvation" strategies in BRCA1 carriers / Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Fernández-Arroyo, Salvador (Hospital Universitari Sant Joan de Reus (Tarragona)) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Joven, Jorge (Hospital Universitari Sant Joan de Reus (Tarragona)) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona)
We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. [...]
2016 - 10.18632/oncotarget.9732
Oncotarget, Vol. 7 (may 2016) , p. 52974-52992  
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20.
18 p, 8.3 MB Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer / Gonzalez-Guerrico, Anatilde M. (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ; Espinoza, Ingrid (Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA) ; Schroeder, Barbara (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ; Park, Cheol Hong (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ; Chandra Mohan, KVP (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ; Khurana, Ashwani (Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA) ; Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Kleer, Celina (Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Lupu, Ruth (Mayo Clinic Cancer Center, Rochester, MN, USA)
The correction of specific signaling defects can reverse the oncogenic phenotype of tumor cells by acting in a dominant manner over the cancer genome. Unfortunately, there have been very few successful attempts at identifying the primary cues that could redirect malignant tissues to a normal phenotype. [...]
2016 - 10.18632/oncotarget.9463
Oncotarget, Vol. 7 (may 2016) , p. 71151-71168  
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