Home > Search Results: Alarcón Cor, Tomás
  Search Tips
Advanced Search
Search collections:
Sort by: Display results: Output format:
Results overview: Found 12 records in 0.03 seconds.
Articles, 9 records found
Research literature, 3 records found
Articles 9 records found  
1.
6 p, 3.0 MB Minimum action path theory reveals the details of stochastic transitions out of oscillatory states / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Perez-Carrasco, Ruben (University College London. Department of Mathematics (UK)) ; Guerrero, Pilar (University College London. Department of Mathematics (UK)) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Page, Karen M. (University College London. Department of Mathematics (UK)) ; Universitat Autònoma de Barcelona. Centre de Recerca Matemàtica
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Transitions between such states are studied as noise-driven escape problems in the chemical species space. Escape can occur via multiple possible multidimensional paths, with probabilities depending nonlocally on the noise. [...]
2018 - 10.1103/PhysRevLett.120.128102
Physical review letters, Vol. 120, Issue 12 (March 2018) , art. 128102  
Detailed record - Creative Commons
2.
27 p, 3.0 MB A multiscale model of epigenetic heterogeneity-driven cell fate decision-making / Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Pérez Carrasco, Rubén (University College London. Department of Mathematics) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Universitat Autònoma de Barcelona. Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592  
Detailed record - Creative Commons
3.
2 p, 566.7 KB De la Cruz et al. Reply / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Perez-Carrasco, Rubén (University College London. Department of Mathematics) ; Guerrero, Pilar (University College London. Department of Mathematics) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Page, Karen M. (University College London. Department of Mathematics)
2019 - 10.1103/PhysRevLett.122.059802
Physical review letters, Vol. 122, Issue 5 (February 2019) , art. 059802  
Detailed record - Creative Commons
4.
18 p, 918.2 KB Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth / Cruz Moreno, Roberto de la, (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Guerrero, Pilar (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Calvo, Juan (Universidad de Granada. Departmento de Matemática Aplicada) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
The development of hybrid methodologies is of current interest in both multi-scale modelling and stochastic reaction-diffusion systems regarding their applications to biology. We formulate a hybrid method for stochastic multi-scale models of cells populations that extends the remit of existing hybrid methods for reaction-diffusion systems. [...]
2017 - 10.1016/j.jcp.2017.09.019
Journal of computational physics, Vol. 350 (Dec. 2017) , p. 974-991  
Detailed record - Creative Commons
5.
23 p, 2.3 MB Stochastic multi-scale models of competition within heterogeneous cellular populations : Simulation methods and mean-field analysis / Cruz Moreno, Roberto de la (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Guerrero, Pilar (University College London. Department of Mathematics) ; Spill, Fabian (Boston University. Department of Biomedical Engineering) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated proliferation rate. [...]
2016 - 10.1016/j.jtbi.2016.07.028
Journal of theoretical biology, Vol. 407 (Oct. 2016) , p. 161-183  
Detailed record - Creative Commons
6.
13 p, 3.9 MB Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome / Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ; Folguera-Blasco, Núria (Centre de Recerca Matemàtica) ; Cuyàs Navarro, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971  
Detailed record - Creative Commons
7.
11 p, 2.4 MB Oncometabolic nuclear reprogramming of cancer stemness / Menendez, Javier A. (Institut Català d'Oncologia) ; Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ; Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; García, María G. (Instituto Universitario de Oncología del Principado de Asturias) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Fraga, Mario F. (Instituto Universitario de Oncología del Principado de Asturias) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. [...]
2016 - 10.1016/j.stemcr.2015.12.012
Stem cell reports, Vol. 6, issue 3 (March 2016) , p. 273-283  
Detailed record - Creative Commons
8.
17 p, 1.1 MB Hybrid approaches for multiple-species stochastic reaction-diffusion models / Spill, Fabian (Boston University. Department of Mechanical Engineering) ; Guerrero, Pilar (University College London. Department of Mathematics) ; Alarcón Cor, Tomás (Centre de Recerca Matemàtica) ; Maini, Philip K. (Wolfson Centre for Mathematical Biology) ; Byrne, Helen (Wolfson Centre for Mathematical Biology)
Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or animals, which move and/or react in a stochastic manner. [...]
2015 - 10.1016/j.jcp.2015.07.002
Journal of computational physics, Vol. 299 (Oct. 2015) , p. 429-445  
Detailed record - Creative Commons
9.
4 p, 1.6 MB Metabostemness : metaboloepigenetic reprogramming of cancer stem-cell functions / Menendez, Javier A. (Institut Català d'Oncologia) ; Corominas-Faja, Bruna (Institut Català d'Oncologia) ; Cuyàs Navarro, Elisabet (Institut Català d'Oncologia) ; Alarcón Cor, Tomás (Centre de Recerca Matematica)
Cancer researchers are currently embarking on one of their field's biggest challenges, namely the understanding of how cellular metabolism or certain classes of elite metabolites (e. g. , oncometabolites) can directly influence chromatin structure and the functioning of epi-transcriptional circuits to causally drive tumour formation. [...]
2014
Oncoscience, Vol. 1 (Dec. 2014) , p. 803-806  
Detailed record - Creative Commons

Research literature 3 records found  
1.
142 p, 2.3 MB Information transmission through a nonlinear molecular signaling system : ErbB as a case study / Beltrán Sáez, Elisa, autor. ; Alarcón Cor, Tomás, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Matemàtiques
La capacitat dels éssers vius d'obtenir i processar informació és clau per adaptar-se i sobreviure en l'ambient que els envolta. Les cèl·lules, des de procariotes unicel·lulars fins a organismes multicel·lulars (eucariotes), capten informació de l'entorn mitjançant diversos mecanismes, entre ells a través de receptors de membrana, que fan de canal per a la informació entre l'exterior i l'interior de la cèl·lula. [...]
The ability of organisms to extract and store information from their surroundings marked a revolution in the history of life and allowed survival and adaptation to the environment. Cells, from prokaryots to eukaryots, use specific receptors inserted in their membranes to detect extracellular molecules that cannot cross into the cell, where cell decisions are taken. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
Detailed record - Creative Commons
2.
252 p, 4.8 MB Stochastic modelling of epigenetic regulation : analysis of its heterogeneity and its implications in cell plasticity / Folguera Blasco, Núria, autor. ; Alarcón Cor, Tomás, supervisor acadèmic. ; Menéndez Menéndez, Javier, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Matemàtiques ; Universitat Autònoma de Barcelona. Centre de Recerca Matemàtica
En aquesta tesi doctoral, el nostre objectiu principal és entendre la importància de la regulació epigenètica en la determinació del destí cel lular i de les seves possibles tran- sicions cap a altres estats. [...]
In this thesis, we aim at understanding the importance of epigenetic regulation(ER) in cell fate decisions and transitions. In order to address this issue, we first formulate a stochastic model of epigenetic regulation. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
Detailed record - Creative Commons
3.
151 p, 3.4 MB Stochastic multi-scale modelling of tumour growth / Cruz Moreno, Roberto de la, autor. ; Alarcón Cor, Tomás, supervisor acadèmic. ; Guerrero, Pilar, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Matemàtiques ; Universitat Autònoma de Barcelona. Centre de Recerca Matemàtica
El cáncer es una de las principales causas de muerte en el mundo. A pesar de todos los recursos invertidos en la investigación para el desarrollo de nuevas terapias, los tratamientos más usados en la lucha contra el cáncer siguen siendo terapias inespecíficas (cirugía, radioterapia y quimioterapia) que afectan tanto a las células cancerígenas como a las sanas. [...]
Cancer is one of the principal causes of death in the world . Despite all the resources invested in research for the development of new targeted therapies, the most used treatments to fight cancer continue to be non-specific therapies, such as surgery, radiotherapy and chemotherapy, that affect both healthy and cancer cells. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
Detailed record - Creative Commons

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.
UAB Digital Repository of Documents :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.6
Maintained by ddd.bib@uab.cat  :: Metadata license:
Working with