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Articles 19 records found  previous11 - 19  jump to record: Search took 0.01 seconds. 
11.
12 p, 2.2 MB Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy / Yáñez-Bisbe, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Elias, Anna (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Tajes, Marta (Institut d'Investigació Biomèdica de Bellvitge) ; Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rodríguez-Sinovas, Antonio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Inserte, Javier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Ruiz Meana, Marisol (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina) ; Benito, Begoña (Universitat Autònoma de Barcelona. Departament de Medicina)
Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. [...]
2021 - 10.3390/ijms23010174
International journal of molecular sciences, Vol. 23 (december 2021)  
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12.
14 p, 1.6 MB Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction / Inserte, Javier (Universitat Autònoma de Barcelona) ; Barrabés, José A.. (Universitat Autònoma de Barcelona) ; Aluja, David (Universitat Autònoma de Barcelona) ; Otaegui, Imanol (Universitat Autònoma de Barcelona) ; Bañeras, Jordi (Universitat Autònoma de Barcelona) ; Castellote, Laura (Hospital Universitari Vall d'Hebron) ; Sánchez, Ana (Universitat Autònoma de Barcelona) ; Rodriguez-Palomares, Jose F (Universitat Autònoma de Barcelona) ; Pineda, Víctor (Institut de Diagnòstic per la Imatge, Barcelona, Spain) ; Miró-Casas, Elisabet (Universitat Autònoma de Barcelona) ; Milà, Laia (Universitat Autònoma de Barcelona) ; Lidón, Rosa-Maria (Universitat Autònoma de Barcelona) ; Sambola, Antonia (Universitat Autònoma de Barcelona) ; Valente, Filipa (Universitat Autònoma de Barcelona) ; Rafecas, Agnès (Universitat Autònoma de Barcelona) ; Ruiz-Meana, Marisol (Universitat Autònoma de Barcelona) ; Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona) ; Benito, Begoña (Universitat Autònoma de Barcelona) ; Buera Surribas, Irene (Universitat Autònoma de Barcelona) ; Delgado-Tomás, Sara (Universitat Autònoma de Barcelona) ; Beneitez Pastor, David (Vall d'Hebron Institut d'Oncologia) ; Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona)
In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as assessed by cardiac magnetic resonance imaging. [...]
2021 - 10.1016/j.jacbts.2021.05.004
JACC: Basic to Translational Science, Vol. 6 (july 2021) , p. 567-580  
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13.
10 p, 2.0 MB Connexin 43 deficiency is associated with reduced myocardial scar size and attenuated tgfβ1 signaling after transient coronary occlusion in conditional knock-out mice / Valls-Lacalle, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ; Consegal, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Benito, Begoña (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Inserte, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Previous studies demonstrated a reduction in myocardial scar size in heterozygous Cx43-mice subjected to permanent coronary occlusion. However, patients presenting with ST segment elevation myocardial infarction often undergo rapid coronary revascularization leading to prompt restoration of coronary flow. [...]
2020 - 10.3390/biom10040651
Biomolecules, Vol. 10 Núm. 4 (april 2020) , p. 651  
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14.
11 p, 1.5 MB CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform) : A multicenter preclinical network for testing reproducibility in cardiovascular interventions / Rossello, Xavier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Rodriguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Crisóstomo, Verónica (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Jorge, Inmaculada (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Zaragoza, Carlos (Universidad Francisco de Vitoria) ; Zamorano, José L. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Bermejo, Javier (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ; Ordoñez, A. (Instituto de Biomedicina de Sevilla) ; Boscá, Lisardo (Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM)) ; Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez-Margallo, F. M. (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ; García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibanez, Borja (Hospital Universitario Fundación Jiménez Díaz) ; Universitat Autònoma de Barcelona
Despite many cardioprotective interventions have shown to protect the heart against ischemia/reperfusion injury in the experimental setting, only few of them have succeeded in translating their findings into positive proof-of-concept clinical trials. [...]
2019 - 10.1038/s41598-019-56613-6
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 20290  
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15.
14 p, 2.3 MB Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion / Penela, Petronila (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Inserte, Javier (Universitat Autònoma de Barcelona) ; Ramos, Paula (Centro de Biología Molecular Severo Ochoa) ; Rodriguez-Sinovas, Antonio (Universitat Autònoma de Barcelona) ; García-Dorado, David (Universitat Autònoma de Barcelona) ; Mayor, F. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Background: Identification of signaling pathways altered at early stages after cardiac ischemia/reperfusion (I/R) is crucial to develop timely therapies aimed at reducing I/R injury. The expression of G protein-coupled receptor kinase 2 (GRK2), a key signaling hub, is up-regulated in the long-term in patients and in experimental models of heart failure. [...]
2019 - 10.1016/j.ebiom.2019.09.019
EBioMedicine, Vol. 48 (october 2019) , p. 605-618  
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16.
17 p, 2.8 MB Opposite effects of moderate and extreme Cx43 deficiency in conditional Cx43-deficient mice on angiotensin II-induced cardiac fibrosis / Valls de Lacalle, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Negre-Pujol, Corall (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Varona, Saray (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Valera Cañellas, Antoni (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Consegal, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Martínez-González, José (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Universitat Autònoma de Barcelona
Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43fl/fl and Cx43Cre-ER(T)/fl inducible knock-out (Cx43 content: 50%) mice treated with vehicle or 4-hydroxytamoxifen (4-OHT) to induce a Cre-ER(T)-mediated global deletion of the Cx43 floxed allele. [...]
2019 - 10.3390/cells8101299
Cells, Vol. 8 (2019) , p. 1-17  
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17.
16 p, 4.3 MB Ischemic postconditioning reduces reperfusion arrhythmias by adenosine receptors and protein kinase C activation but is independent of KATP channels or connexin 43 / Diez, E. R. (Institute of Medical and Experimental Biology of Cuyo. CONICET) ; Sánchez, J. A. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Prado, N. J. (Institute of Medical and Experimental Biology of Cuyo. CONICET) ; Zumino, A. Z. P. (Institute of Medical and Experimental Biology of Cuyo. CONICET) ; García-Dorado, David (Universitat Autònoma de Barcelona. Departament de Medicina) ; Miatello, R. M. (Institute of Medical and Experimental Biology of Cuyo. CONICET) ; Rodríguez-Sinovas, A. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Ischemic postconditioning (IPoC) reduces reperfusion arrhythmias but the antiarrhythmic mechanisms remain unknown. The aim of this study was to analyze IPoC electrophysiological effects and the role played by adenosine A, A and A receptors, protein kinase C, ATP-dependent potassium (K) channels, and connexin 43. [...]
2019 - 10.3390/ijms20235927
International journal of molecular sciences, Vol. 20 Núm. 23 (january 2019) , p. 5927  
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18.
15 p, 2.3 MB Defective sarcoplasmic reticulum-mitochondria calcium exchange in aged mouse myocardium / Fernández Sanz, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz-Meana, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Miro-Casas, E. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nuñez, E. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Castellano, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Loureiro, M. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Poncelas, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez-Sinovas, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Mitochondrial alterations are critically involved in increased vulnerability to disease during aging. We investigated the contribution of mitochondria-sarcoplasmic reticulum (SR) communication in cardiomyocyte functional alterations during aging. [...]
2014 - 10.1038/cddis.2014.526
Cell death and disease, Vol. 5 (december 2014) , p. e1573  
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19.
21 p, 3.3 MB Single Intracoronary Injection of Encapsulated Antagomir-92a Promotes Angiogenesis and Prevents Adverse Infarct Remodeling / Bellera Gotarda, Neus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferret, Eulalia (I+D Pierre-Fabre Ibérica S.A) ; Asín, Miguel Angel (I+D Pierre-Fabre Ibérica S.A) ; Gonzalez-Alujas, MªTeresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pérez-Rodón, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteves, Marielle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fonseca, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Toran, Nuria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ; Pérez, Amadeo (I+D Pierre-Fabre Ibérica S.A) ; García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Small and large preclinical animal models have shown that antagomir-92a-based therapy reduces early postischemic loss of function, but its effect on postinfarction remodeling is not known. In addition, the reported remote miR-92a inhibition in noncardiac organs prevents the translation of nonvectorized miR-targeted therapy to the clinical setting. [...]
2014 - 10.1161/JAHA.114.000946
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 3 (september 2014)  
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Articles : 19 records found   previous11 - 19  jump to record:
See also: similar author names
19 Rodriguez-Sinovas, Antonio
2 Rodríguez-Sinovas, A.
19 Rodríguez-Sinovas, Antonio
3 Rodríguez-Sinovas, Antonio,
2 Rodríguez-sinovas, A.
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