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Articles 476 records found  beginprevious98 - 107nextend  jump to record: Search took 0.00 seconds. 
98.
12 p, 15.4 MB How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines : The spring viremia carp virus (SVCV) case / Rojas-Peña, Mauricio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Aceituno Abarzúa, Patricia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Salvador, Maria E. (Universidad Miguel Hernández. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche) ; Garcia-Ordoñez, Marlid (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ortega-Villaizan, Maria del Mar (Universidad Miguel Hernández . Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche) ; Perez, Luis (Universidad Miguel Hernández. Instituto de Investigación. Desarrollo e Innovación en Biotecnología Sanitaria de Elche) ; Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Spring viremia of carp (SVC) remains as a vaccine orphan disease mostly affecting juvenile specimens. Young fish are especially difficult to vaccinate and oral administration of vaccine combined with food would be the election system to minimise stress and the vaccination costs associated to injection. [...]
2022 - 10.1016/j.fsi.2022.10.067
Fish and Shellfish Immunology, Vol. 131 (December 2022) , p. 1051-1062  
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99.
16 p, 3.1 MB Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles : An Optimized Protocol / Fernández, Roger (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Carreño, Aida (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Benito, Antoni (Institut d'Investigació Biomèdica de Girona) ; Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vaults are protein nanoparticles that are found in almost all eukaryotic cells but are absent in prokaryotic ones. Due to their properties (nanometric size, biodegradability, biocompatibility, and lack of immunogenicity), vaults show enormous potential as a bio-inspired, self-assembled drug-delivery system (DDS). [...]
2022 - 10.3390/ijms232415543
International journal of molecular sciences, Vol. 23, Issue 24 (December 2022) , art. 15543  
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100.
12 p, 339.3 KB Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC : Results From the Phase 3 TAHOE Study / Blackhall, Fiona (Department of Medical Oncology. The Christie National Health Service (NHS) Foundation Trust) ; Jao, K. (Department of Hematology and Oncology. Hopital du Sacre Coeur Montreal) ; Greillier, L. (Multidisciplinary Oncology and Therapeutic Innovations Department. Centre de Recherche en Cancérologie de Marseille (CRCM). Centre National de la Recherche Scientifique (CNRS). Institut National de la Santé et de la Recherche Médicale (INSERM). Assistance Publique-Hopitaux de Marseille (APHM). Aix-Marseille University) ; Cho, B.C. (Division of Medical Oncology. Department of Internal Medicine. Yonsei Cancer Center. Yonsei University College of Medicine) ; Penkov, K. (Private Medical Institution Euromedservice) ; Reguart, Noemi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Nackaerts, K. (Department of Pulmonology and Respiratory Oncology. University Hospital Leuven. Katholieke Universiteit (KU) Leuven) ; Syrigos, K. (Department of Medicine. National and Kapodistrian University of Athens) ; Hansen, K. (Odense University Hospital (Dinamarca)) ; Schuette, W. (2nd Medical Department. Krankenhaus Martha-Maria Halle-Doelau. Halle) ; Cetnar, J. (Department of Medicine. Oregon Health & Science University) ; Cappuzzo, F. (Department of Medical Oncology. Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)) ; Okamoto, I. (Department of Medical Oncology. Kyushu University Hospital) ; Erman, M. (Department of Medical Oncology. Cancer Institute. Hacettepe University) ; Langer, S.W. (Rigshospitalet. University of Copenhagen) ; Kato, T. (Department of Thoracic Oncology. Kanagawa Cancer Center) ; Groen, H. (Department of Pulmonary Disease. University Medical Center Groningen. University of Groningen) ; Sun, Z. (AbbVie. Inc.) ; Luo, Y. (AbbVie. Inc.) ; Tanwani, P. (AbbVie. Inc.) ; Caffrey, L. (AbbVie. Inc.) ; Komarnitsky, P. (AbbVie. Inc.) ; Reinmuth, N. (Thoracic Oncology Department. Asklepios Fachkliniken München-Gauting)
Introduction: DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate containing a DLL3-targeting antibody tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. [...]
2021 - 10.1016/j.jtho.2021.02.009
Journal of Thoracic Oncology, Vol. 16 Núm. 9 (september 2021) , p. 1547-1558  
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101.
13 p, 2.5 MB TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels / Hong, Shengjun (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ; Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ; Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ; Bos, Isabelle (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ; Vos, Stephanie J.B. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ; Prokopenko, Dimitry (Massachusetts General Hospital (Boston)) ; Tijms, Betty M. (Vrije Universiteit Amsterdam) ; Andreasson, Ulf (Sahlgrenska University Hospital (Suècia)) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (KU Leuven. Department of Neurosciences) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ; Engelborghs, Sebastiaan (Vrije Universiteit Brussel) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (AIX Marseille University. INS. Ap-hm) ; Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ; Bordet, Régis (Inserm. CHU Lille. University of Lille) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Lausanne University Hospital) ; Clark, Christopher (University Hospital of Psychiatry Zurich) ; Peyratout, Gwendoline (University Hospital of Lausanne. Department of Psychiatry) ; Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Dobson, Richard J.B. (University College London. Hospitals Biomedical Research Centre) ; Legido-Quigley, Cristina (King's College London) ; Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ; Van Broeckhoven, Christine (University of Antwerp) ; Tanzi, Rudolph E. (Genetics and Aging Unit and McCance Center for Brain Health. Department of Neurology. Massachusetts General Hospital) ; ten Kate, Mara (Amsterdam UMC. University Medical Center) ; Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Lill, Christina M. (Imperial College. School of Public Health) ; Barkhof, Frederik (University College London. Institutes of Neurology and Healthcare Engineering) ; Lovestone, Simon (University of Oxford. Department of Psychiatry) ; Streffer, Johannes (Translational Medicine Neuroscience. UCB Biopharma SPRL. Braine l'Alleud) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). UK Dementia Research Institute) ; Visser, Pieter J. (Karolinska Instutet. Department of Neurobiology) ; Bertram, Lars (University of Oslo. Department of Psychology)
Introduction: Neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, and synaptic degeneration, respectively. [...]
2021 - 10.1002/alz.12330
Alzheimer's & Dementia, Vol. 17 Núm. 10 (october 2021) , p. 1628-1640  
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102.
21 p, 5.9 MB Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study / Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Casós, Kelly (Hospital Universitari de Bellvitge) ; Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge) ; Permanyer, Eduard (Centro Médico Teknon) ; Máñez, Rafael (Hospital Universitari de Bellvitge) ; Le Tourneau, Thierry (Université de Nantes) ; Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bottio, Tomaso (University Hospital of Padova (Pàdua, Itàlia)) ; Roussel, Jean Christian (CHU de Nantes) ; Fellah-Hebia, Imen (CHU de Nantes) ; Sénage, Thomas (Université de Nantes) ; Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Badano, Luigi P. (San Luca Hospital(Itàlia)) ; Ruiz-Majoral, Alejandro (Hospital Universitari de Bellvitge) ; Galli, Cesare (Avantea and Fondazione Avantea Onlus (Itàlia)) ; Padler-Karavani, Vered (Tel Aviv University) ; Soulillou, Jean-Paul (Centre Hospitalier Universitaire de Nantes) ; Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ; Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ; Costa, Cristina (Hospital Universitari de Bellvitge) ; Universitat Autònoma de Barcelona
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. [...]
2022 - 10.3390/biom12111606
Biomolecules, Vol. 12 (october 2022)  
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103.
13 p, 2.0 MB Fungal Hal3 (and Its Close Relative Cab3) as Moonlighting Proteins / Casamayor Gracia, Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Hal3 (Sis2) is a yeast protein that was initially identified as a regulatory subunit of the Saccharomyces cerevisiae Ser/Thr protein phosphatase Ppz1. A few years later, it was shown to participate in the formation of an atypical heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme, thus catalyzing a key reaction in the pathway leading to Coenzyme A biosynthesis. [...]
2022 - 10.3390/jof8101066
Journal of Fungi, Vol. 8, Issue 10 (October 2022) , art. 1066  
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104.
15 p, 4.9 MB Analysis of Host-Bacteria Protein Interactions Reveals Conserved Domains and Motifs That Mediate Fundamental Infection Pathways / Gómez Borrego, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Adhesion and colonization of host cells by pathogenic bacteria depend on protein-protein interactions (PPIs). These interactions are interesting from the pharmacological point of view since new molecules that inhibit host-pathogen PPIs would act as new antimicrobials. [...]
2022 - 10.3390/ijms231911489
International journal of molecular sciences, Vol. 23, Issue 19 (September 2022) , art. 11489  
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105.
40 p, 1.6 MB Deregulation of methanol metabolism reverts transcriptional limitations of recombinant Pichia pastoris (Komagataella spp) with multiple expression cassettes under control of the AOX1 promoter / Cámara, Elena (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Monforte, Sergi (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Albiol i Sala, Joan (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
The methanol-regulated alcohol oxidase promoter (PAOX1) of Pichia pastoris (syn. Komagataella spp. ) is one of the strongest promoters for heterologous gene expression. Although increasing the gene dosage is a common strategy to improve recombinant protein productivities, P. [...]
2019 - 10.1002/bit.26947
Biotechnology and Bioengineering, Vol. 116, Issue 7 (July 2019) , p. 1710-1720  
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106.
16 p, 2.4 MB Carbohydrate hydrolytic potential and redundancy of an anaerobic digestion microbiome exposed to acidosis, as uncovered by metagenomics / Bertucci, Marie (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department) ; Calusinska, Magdalena (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department) ; Goux, Xavier (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department) ; Rouland-Lefèvre, Corinne (Sorbonne Universités. Institut de Recherche Développement. Institut d'Ecologie et des Sciences de l'Environnement) ; Untereiner, Boris (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department) ; Ferrer, Pau (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department) ; Gerin, Patrick A. (Université Catholique de Louvain. Laboratory of Bioengineering, Earth) ; Delfosse, Philippe (Luxembourg Institute of Science and Technology. Environmental Research and Innovation Department)
Increased hydrolysis of easily digestible biomass may lead to acidosis of anaerobic reactors and decreased methane production. Previously, it was shown that the structure of microbial communities changed during acidosis; however, once the conditions are back to optimal, biogas (initially CO2) production quickly restarts. [...]
2019 - 10.1128/AEM.00895-19
Applied and Environmental Microbiology, Vol. 85, Issue 15 (August 2019) , p. e00895-19  
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107.
11 p, 1.6 MB Process intensification at the expression system level for the production of 1-phosphate aldolase in antibiotic-free E. coli fed-batch cultures / Pasini, Martina (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Fernández-Castané, Alfred (Aston University. Aston Institute of Materials Research) ; Caminal i Saperas, Glòria (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Overton, Tim W. (University of Birmingham. College of Engineering and Physical Sciences) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
To successfully design expression systems for industrial biotechnology and biopharmaceutical applications; plasmid stability, efficient synthesis of the desired product and the use of selection markers acceptable to regulatory bodies are of utmost importance. [...]
2022 - 10.1093/jimb/kuac018
Journal of Industrial Microbiology and Biotechnology, Vol. 49, Issue 4 (July 2022) , art. kuac018  
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