Artículos

Artículos Encontrados 27 registros  inicioanterior18 - 27  ir al registro: La búsqueda tardó 0.00 segundos. 
18.
15 p, 1.9 MB Silencing of adaptor protein 32 reduces / receptors expression and impairs gastrointestinal stromal tumors growth / Serrano-Candelas, Eva (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ainsua-Enrich, Erola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Navinés-Ferrer, Arnau (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Valverde, Alfonso (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona) ; Serrano, César (Hospital Universitari Vall d'Hebron) ; Sayós, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martin, Margarita (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gastrointestinal stromal tumors (s) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most s contain oncogenic (85%) or (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of drug resistance has highlighted the need for novel therapeutic strategies. [...]
2018 - 10.1002/1878-0261.12332
Molecular Oncology, Vol. 12 (june 2018) , p. 1383-1397  
19.
14 p, 3.0 MB The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1 / Nadal-Serrano, Mercedes (Vall d'Hebron Institut d'Oncologia) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Escrivá-de-Romaní, Santiago (Hospital Universitari Vall d'Hebron) ; Bernadó Morales, Cristina (Vall d'Hebron Institut d'Oncologia) ; Luque, Antonio (Vall d'Hebron Institut d'Oncologia) ; Escorihuela, Marta (Vall d'Hebron Institut d'Oncologia) ; Espinosa-Bravo, Martín (Hospital Universitari Vall d'Hebron) ; Peg, Vicente (Hospital Universitari Vall d'Hebron) ; Dijcks, Fred A. (Preclinical R&D, The Netherlands) ; Dokter, Wim H. A. (Preclinical R&D, The Netherlands) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Saura, Cristina (Hospital Universitari Vall d'Hebron) ; Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2 (human epidermal growth factor receptor 2)-positive breast cancer. T-DM1 consists of trastuzumab covalently linked to the cytotoxic maytansinoid DM1 via a non-cleavable linker. [...]
2020 - 10.3390/cancers12030670
Cancers, Vol. 12 (march 2020)  
20.
43 p, 3.9 MB LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells / Cebrià Costa, Joan Pau (Vall d'Hebron Institut d'Oncologia) ; Pascual Reguant, Laura (Vall d'Hebron Institut d'Oncologia) ; Gonzalez-Perez, Abel (Institute for Research in Biomedicine (IRB Barcelona)) ; Serra-Bardenys, Gemma (Vall d'Hebron Institut d'Oncologia) ; Querol, Jessica (Vall d'Hebron Institut d'Oncologia) ; Cosín Tomás, Marc (Vall d'Hebron Institut d'Oncologia) ; Verde, Gaetano (Universitat Internacional de Catalunya. Facultat de Ciències de la Salut) ; Aiese Cigliano, Riccardo (Sequentia Biotech SL) ; Sanseverino, Walter. (Sequentia Biotech SL) ; Segura-Bayona, Sandra (Institute for Research in Biomedicine (IRB Barcelona)) ; Iturbide, Ane (Institute of Epigenetics and Stem Cells) ; Andreu Martínez, David (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Nuciforo, Paolo. (Vall d'Hebron Institut d'Oncologia) ; Bernadó Morales, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ; Rodilla, Verónica (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Yélamos, José (Institut Hospital del Mar d'Investigacions Mèdiques) ; Garcia de Herreros, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ; Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ; Peiró, Sandra (Vall d'Hebron Institut d'Oncologia)
Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient-derived xenografts (PDXs) than those from other breast cancer subtypes. [...]
2020 - 10.1038/s41388-019-0969-1
Oncogene, Vol. 39 (2020) , p. 79-121  
21.
16 p, 5.4 MB HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503 / Gorbatenko, A. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen) ; Søkilde, R. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Sorensen, E. E. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen) ; Newie, I. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Persson, H. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Litman, T. (Department of International Health. Immunology and Microbiology. University of Copenhagen) ; Rovira, Carlos (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Pedersen, S. F. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen)
The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towards the basal breast cancer subtype. [...]
2019 - 10.1038/s41598-019-39733-x
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3352  
22.
8 p, 473.7 KB RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer / Cruz, C. (Vall d'Hebron Institut d'Oncologia) ; Castroviejo-Bermejo, Marta (Experimental Therapeutics Group) ; Gutiérrez-Enríquez, Sara (Oncogenetics Group) ; Llop-Guevara, A. (Experimental Therapeutics Group) ; Ibrahim, Y. H. (Experimental Therapeutics Group) ; Gris-Oliver, Albert. (Experimental Therapeutics Group) ; Bonache, Sandra (Oncogenetics Group) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Bruna, Alejandra (Cancer Research UK Cambridge Institute. University of Cambridge) ; Rueda, O. M. (Cancer Research UK Cambridge Institute. University of Cambridge) ; Lai, Z. (AstraZeneca (USA)) ; Polanska, U. M. (Cancer Research UK. Cambridge Institute) ; Jones, G. N. (Cancer Research UK. Cambridge Institute) ; Kristel, P. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; de Bustos, L. (Experimental Therapeutics Group) ; Guzmán, Marta (Experimental Therapeutics Group) ; Rodríguez, O. (Experimental Therapeutics Group) ; Grueso, Judit (Experimental Therapeutics Group) ; Montalban, G. (Oncogenetics Group) ; Caratù, Ginevra (Cancer Genomics Group) ; Mancuso, Francesco M (Cancer Genomics Group) ; Fasani, R. (Vall d'Hebron Institut d'Oncologia) ; Jiménez, J. (Vall d'Hebron Institut d'Oncologia) ; Howat, W. J. (Cancer Research UK. Cambridge Institute) ; Dougherty, B. (AstraZeneca (USA)) ; Vivancos, A. (Cancer Genomics Group) ; Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ; Serres-Créixams, X. (Department of Radiology) ; Rubio Rodríguez, Isabel Teresa (Hospital Universitari Vall d'Hebron) ; Oaknin, Ana (Vall d'Hebron Institut d'Oncologia) ; Cadogan, E. (Cancer Research UK. Cambridge Institute) ; Barrett, J. Carl (AstraZeneca (USA)) ; Caldas, Carlos (NIHR Cambridge Biomedical Research Centre (Regne Unit)) ; Baselga Torres, Josep, 1959-2021, (Memorial Sloan Kettering Cancer Center) ; Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V. (Vicente) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Jonkers, Jos (Cancer Genomics Group) ; Diez, Orland (Hospital Universitari Vall d'Hebron) ; O'Connor, M. J. (Oncology Innovative Medicine and Early Development Biotech Unit. AstraZeneca (UK)) ; Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ; Serra, Violeta (Vall d'Hebron Institut d'Oncologia)
BRCA1 and BRCA2 (BRCA1/2) -deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi). [...]
2018 - 10.1093/annonc/mdy099
Annals of oncology, Vol. 29, Issue 5 (May 2018) , p. 1203-1210  
23.
16 p, 2.6 MB Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis / Martín-Pérez, Rosa (Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium) ; Yerbes, Rosario (Centro Andaluz de Biología Molecular y Medicina Regenerativa) ; Mora-Molina, Rocío (Centro Andaluz de Biología Molecular y Medicina Regenerativa) ; Cano-González, Ana (Centro Andaluz de Biología Molecular y Medicina Regenerativa) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Mazzone, Massimiliano (Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium) ; López-Rivas, Abelardo (Centro de Investigación Biomédica en Red de Cáncer) ; Palacios, Carmen (Centro Andaluz de Biología Molecular y Medicina Regenerativa)
Oncogenic transformation triggers reprogramming of cell metabolism, as part of the tumorigenic process. However, metabolic reprogramming may also increase the sensitivity of transformed cells to microenvironmental stress, at the early stages of tumor development. [...]
2017 - 10.18632/oncotarget.21458
Oncotarget, Vol. 8 (october 2017) , p. 93688-93703  
24.
10 p, 3.3 MB Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts / Morancho, Beatriz (Hospital Universitari Vall d'Hebron) ; Zacarías-Fluck, Mariano F (Hospital Universitari Vall d'Hebron) ; Esgueva, Antonio (Hospital Universitari Vall d'Hebron) ; Bernadó Morales, Cristina (Hospital Universitari Vall d'Hebron) ; Cosimo, Serena Di (Division of Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy) ; Prat, Aleix (Hospital Universitari Vall d'Hebron) ; Cortés, Javier (Hospital Universitari Vall d'Hebron) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rubio, Isabel T. (Hospital Universitari Vall d'Hebron)
The pleiotropic cytokine IL-6 accelerates the progression of breast cancer in a variety of preclinical models through the activation of the STAT3 (signal transducer and activator of transcription 3) signaling pathway. [...]
2016 - 10.18632/oncotarget.11815
Oncotarget, Vol. 7 (september 2016) , p. 67956-67965  
25.
12 p, 2.5 MB Cancer network activity associated with therapeutic response and synergism / Serra-Musach, Jordi (Institut Català d'Oncologia) ; Mateo, Francesca (Institut Català d'Oncologia) ; Capdevila-Busquets, Eva (Institut de Recerca Biomèdica de Lleida) ; Ruiz de Garibay, Gorka (Institut Català d'Oncologia) ; Zhang, Xiaohu (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ; Guha, Raj (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ; Thomas, Craig J. (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ; Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ; Villanueva, Alberto (Institut Català d'Oncologia) ; Jaeger, Samira (Institut de Recerca Biomèdica de Lleida) ; Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ; Vizoso, Miguel (Institut d'Investigació Biomèdica de Bellvitge) ; Pérez Montero, Hector (Institut d'Investigació Biomèdica de Bellvitge) ; Cordero, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; González Suarez, Eva (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ; Moreno-Bueno, Gema (Universidad Autónoma de Madrid. Departamento de Bioquímica) ; Tjärnberg, Andreas (Linköping University. Departament of Clinical and Experimental Medicine) ; Lázaro, Conxi (Institut Català d'Oncologia) ; Serra, Violeta (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V. (Vicente) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Benson, Mikael (Linköping University. Department of Clinical and Experimental Medicine) ; Gustafsson, Mika (Linköping University. Department of Clinical and Experimental Medicine) ; Ferrer, Marc (National Center for Advancing Translational Sciences (Bethesda, Estats Units d'Amèrica)) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats) ; Pujana, Miquel Àngel (Institut Català d'Oncologia)
Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. [...]
2016 - 10.1186/s13073-016-0340-x
Genome Medicine, Vol. 8 (August 2016) , ART. 88  
26.
14 p, 6.9 MB Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer / Hergueta-Redondo, Marta (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Sarrio, David (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Molina-Crespo, Ángela (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Vicario, Rocío (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bernadó Morales, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez, Lidia (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Rojo-Sebastián, Alejandro (Pathology Department, MD Anderson Cancer Center, Madrid, Spain) ; Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ; Mota, Alba (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ; Martínez-Ramírez, Ángel (Cytogenetics Department, MD Anderson Cancer Center, Madrid, Spain) ; Castilla, Maria Ángeles (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; González-Martin, Antonio (Oncology Department, MD Anderson Cancer Center, Madrid, Spain) ; Pernas, Sonia (Institut d'Investigació Biomèdica de Bellvitge) ; Cano, Amparo (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Cortés, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nuciforo, Paolo. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peg, Vicente (Hospital Universitari Vall d'Hebron) ; Palacios, José (Hospital Universitario Ramón y Cajal (Madrid)) ; Pujana, Miguel Ángel (Institut d'Investigació Biomèdica de Bellvitge) ; Arribas, Joaquín V (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moreno-Bueno, Gema (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ; Universitat Autònoma de Barcelona
Around, 30-40% of HER2-positive breast cancers do not show substantial clinical benefit from the targeted therapy and, thus, the mechanisms underlying resistance remain partially unknown. Interestingly, ERBB2 is frequently co-amplified and co-expressed with neighbour genes that may play a relevant role in this cancer subtype. [...]
2016 - 10.18632/oncotarget.10787
Oncotarget, Vol. 7 (july 2016) , p. 56295-56308  
27.
10 p, 1.9 MB High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy / Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ; Thyparambil, Sheeno (OncoPlex Diagnostics. USA) ; Aura, Claudia (Vall d'Hebron Institut d'Oncologia) ; Garrido-Castro, Ana (Hospital Universitari Vall d'Hebron) ; Vilaro, Marta (Vall d'Hebron Institut d'Oncologia) ; Peg, Vicente (Hospital Universitari Vall d'Hebron) ; Jimenez, José (Vall d'Hebron Institut d'Oncologia) ; Vicario, Rocío (Vall d'Hebron Institut d'Oncologia) ; Cecchi, Fabiola (OncoPlex Diagnostics. USA) ; Hoos, William (OncoPlex Diagnostics. USA) ; Burrows, Jon (OncoPlex Diagnostics. USA) ; Hembrough, Todd (OncoPlex Diagnostics. USA) ; Ferreres Piñas, Joan Carles (Hospital Universitari Vall d'Hebron) ; Pérez-Garcia, José (Hospital Universitari Vall d'Hebron) ; Arribas, Joaquín V. (Vicente) (Institució Catalana de Recerca i Estudis Avançats) ; Cortés, Javier (Hospital Universitari Vall d'Hebron) ; Scaltriti, Maurizio (Memorial Sloan Kettering Cancer Center) ; Universitat Autònoma de Barcelona
Introduction: Current methods to determine HER2 (human epidermal growth factor receptor 2) status are affected by reproducibility issues and do not reliably predict benefit from anti-HER2 therapy. Quantitative measurement of HER2 may more accurately identify breast cancer (BC) patients who will respond to anti-HER2 treatments. [...]
2016 - 10.1016/j.molonc.2015.09.002
Molecular Oncology, Vol. 10, núm 1 (January 2016) , p. 138-147  

Artículos : Encontrados 27 registros   inicioanterior18 - 27  ir al registro:
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