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9 p, 418.0 KB Coexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy in RAS Wild-Type Metastatic Colorectal Cancer Patients / Alonso, Vicente (Hospital Universitario Miguel Servet (Saragossa)) ; Escudero, Pilar (Hospital Clínico Universitario Lozano Blesa) ; Fernández-Martos, Carlos (Fundación Instituto Valenciano de Oncologia) ; Salud, Antonia (Hospital Universitari Arnau de Vilanova) ; Méndez, Miguel (Hospital Universitario de Móstoles (Madrid)) ; Gallego, Javier (Hospital General Universitario de Elche) ; Rodriguez, Jose Ramon (Hospital Infanta Cristina) ; Martín-Richard, Marta (Institut d'Investigació Biomèdica Sant Pau) ; Fernández Plana, Julen (Hospital Mutua de Terrasa) ; Manzano, Hermini (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Méndez Méndez, José Carlos (Centro Oncologico de Galicia) ; Zanui, Montserrat (Hospital de Mataró. Consorci Sanitari del Maresme) ; Falcó, Esther (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ; Gil-Raga, Mireia (Hospital de Sagunto) ; Rojo, Federico (Hospital Fundación Jiménez Díaz) ; Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ; Feliu, Jaime (Hospital Universitario La Paz (Madrid)) ; Garcia-Albeniz, Xabier (Harvard School of Public Health) ; Maurel, Joan (Hospital Clínic i Provincial de Barcelona) ; Universitat Autònoma de Barcelona
The coexpression of pIGF-1R and MMP-7 (double-positive phenotype, DP) correlates with poor overall survival (OS) in KRAS wild-type (WT) (exon 2) metastatic colorectal cancer (mCRC) patients treated with irinotecan-cetuximab in second/third line. [...]
2018 - 10.1016/j.neo.2018.05.004
Neoplasia (New York, N.Y.), Vol. 20 Núm. 7 (july 2018) , p. 678-686  
Detailed record - Creative Commons

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