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16 p, 2.5 MB Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns / Salvadores, Marina (Institut de Recerca Biomèdica de Lleida) ; Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Supek, F. (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. [...]
2020 - 10.1126/sciadv.aba1862
Science advances, Vol. 6 Núm. 27 (july 2020) , p. eaba1862  
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