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20 p, 786.4 KB |
Associations of modern initial antiretroviral drug regimens with all-cause mortality in adults with HIV in Europe and North America : a cohort study
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Trickey, A. (University of Bristol) ;
Zhang, L. (University of Bristol) ;
Gill, M.J. (University of Calgary) ;
Bonnet, F. (Centre Hospitalier Universitaire de Bordeaux) ;
Burkholder, G. (University of Alabama at Birmingham) ;
Castagna, A. (University vita E Salute) ;
Cavassini, M. (Lausanne University Hospital) ;
Cichon, P. (Otto-Wagner Hospital) ;
Crane, H. (University of Washington) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Grabar, S. (St Antoine Hospital) ;
Guest, J. (Emory University) ;
Obel, N. (Copenhagen University Hospital) ;
Psichogiou, M. (National and Kapodistrian University of Athens) ;
Rava, M. (Instituto de Salud Carlos III) ;
Reiss, P. (Amsterdam Institute for Global Health and Development) ;
Rentsch, C.T. (London School of Hygiene & Tropical Medicine) ;
Riera, M. (Fundación Instituto de Investigación Sanitaria Illes Balears) ;
Schuettfort, G. (Frankfurt University Hospital) ;
Silverberg, M.J. (Kaiser Permanente Northern California) ;
Smith, C. (University College London) ;
Stecher, M. (German Center for Infection Research) ;
Sterling, T.R. (Vanderbilt University School of Medicine) ;
Ingle, S.M. (University of Bristol) ;
Sabin, C.A. (University College London) ;
Sterne, J.A.C. (University of Bristol) ;
Universitat Autònoma de Barcelona
Over the past decade, antiretroviral therapy (ART) regimens that include integrase strand inhibitors (INSTIs) have become the most commonly used for people with HIV starting ART. Although trials and observational studies have compared virological failure on INSTI-based with other regimens, few data are available on mortality in people with HIV treated with INSTIs in routine care. [...]
2022 -  10.1016/S2352-3018(22)00046-7
The lancet. HIV, Vol. 9 Núm. 6 (june 2022) , p. e404-e413
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11 p, 1014.2 KB |
The broad phenotypic spectrum of PPP2R1A -related neurodevelopmental disorders correlates with the degree of biochemical dysfunction
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Lenaerts, Lisa (University of Leuven) ;
Reynhout, Sara (KU Leuven Brain Institute (LBI)) ;
Verbinnen, Iris (University of Leuven) ;
Laumonnier, Frédéric (Centre Hospitalier Régional Universitaire (Tours, França)) ;
Toutain, Annick (Centre Hospitalier Régional Universitaire (Tours, França)) ;
Bonnet-Brilhault, Frédérique (Centre Hospitalier Régional Universitaire) ;
Hoorne, Yana (University of Leuven) ;
Joss, Shelagh (Queen Elizabeth University Hospital) ;
Chassevent, Anna K. (Kennedy Krieger Institute) ;
Smith-Hicks, Constance (Kennedy Krieger Institute) ;
Loeys, Bart (University of Antwerp) ;
Joset, Pascal (University of Zurich) ;
Steindl, Katharina (University of Zurich) ;
Rauch, Anita (University of Zurich) ;
Mehta, Sarju G. (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Chung, Wendy (Columbia University Medical Center) ;
Devriendt, Koenraad (University of Leuven) ;
Holder, Susan E. (North West Thames Regional Genetics Service) ;
Jewett, Tamison (Wake Forest University) ;
Baldwin, Lauren M. (Wake Forest University) ;
Wilson, William G. (University of Virginia) ;
Towner, Shelley (University of Virginia) ;
Srivastava, Siddharth (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Johnson, Hannah F. (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Daumer-Haas, Cornelia (Prenatal Medicine Munich) ;
Baethmann, Martina (Klinikum Dritter Orden München) ;
Ruiz, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gabau, Elisabeth (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Jain, Vani (University Hospital of Wales) ;
Varghese, Vinod (University Hospital of Wales) ;
Al-Beshri, Ali (University of Alabama at Birmingham) ;
Fulton, Stephen (Le Bonheur Children's Hospital) ;
Wechsberg, Oded (Maccabi Healthcare Services) ;
Orenstein, Naama (Tel Aviv University) ;
Prescott, Katrina (Leeds Teaching Hospitals NHS Trust) ;
Childs, Anne-Marie (Leeds Teaching Hospitals NHS Trust) ;
Faivre, Laurence (Université de Bourgogne) ;
Moutton, Sébastien (Maison de Santé Bordeaux Bagatelle (Talence, França)) ;
Sullivan, Jennifer A. (Duke University Medical Center) ;
Shashi, Vandana (Duke University Medical Center) ;
Koudijs, Suzanne M. (Maastricht UMC+) ;
Heijligers, Malou (Maastricht UMC+) ;
Kivuva, Emma (Royal Devon & Exeter NHS Foundation Trust) ;
McTague, Amy (Great Ormond Street Hospital for Children (Londres)) ;
Male, Alison M. (Great Ormond Street Hospital for Children (Londres)) ;
van Ierland, Yvette (Erasmus MC) ;
Plecko, Barbara (Medical University of Graz) ;
Maystadt, Isabelle (Institut de Pathologie et de Génétique) ;
Hamid, Rizwan (Vanderbilt University Medical Center) ;
Hannig, Vickie L. (Vanderbilt University Medical Center) ;
Houge, Gunnar (Haukeland University Hospital (Bergen, Noruega)) ;
Janssens, Veerle (KU Leuven Brain Institute (LBI)) ;
Universitat Autònoma de Barcelona
Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A) dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA, and more rarely in PPP2R1A. Here, we aimed to better understand the latter by characterizing 30 individuals with de novo and often recurrent variants in this PP2A scaffolding Aα subunit. [...]
2020 - 10.1038/s41436-020-00981-2
Genetics in medicine, Vol. 23 Num. 2 (feb. 2021) , p. 352-362
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7 p, 259.3 KB |
Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study
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May, Margaret T. ;
Vehreschild, Jorg-Janne ;
Trickey, Adam ;
Obel, Niels ;
Reiss, Peter ;
Bonnet, Fabrice ;
Mary-Krause, Murielle ;
Samji, Hasina ;
Cavassini, Matthias ;
Gill, Michael John ;
Shepherd, Leah C. ;
Crane, Heidi ;
D'Arminio Monforte, Antonella ;
Burkholder, Greer A. ;
Johnson, Margaret M. ;
Sobrino-Vegas, Paz ;
Domingo, Pere (Domingo Pedrol) ;
Zangerle, Robert (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Justice, Amy C. ;
Sterling, Timothy R. ;
Miró, José M. ;
Sterne, Jonathan A. C.
The strong association of CD4 count at start of combination therapy with subsequent survival in HIV-infected patients diminished during the first 5 years of treatment. After 5 years, lower baseline CD4 counts were not associated with higher mortality. [...]
2016 - 10.1093/cid/ciw183
Clinical Infectious Diseases, Vol. 62 (march 2016) , p. 1571-1577
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8 p, 283.7 KB |
When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries : A Prospective Observational Study
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Caniglia, Ellen C. (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA) ;
Sabin, Caroline A. (University College London, London, United Kingdom) ;
Robins, James M. (Department of Biostatistics, Harvard T.H. Chan School of Public Health) ;
Logan, Roger (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Cain, Lauren E. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Abgrall, Sophie (Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Antoine Béclère, Service de Médecine Interne) ;
Mugavero, Michael J. (University of Alabama at Birmingham) ;
Hernandez-Diaz, Sonia (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Meyer, Laurence (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Seng, Remonie (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Drozd, Daniel R. (Division of Allergy and Infectious Diseases, School of Medicine, University of Washington) ;
Seage, George R. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Bonnet, Fabrice (Bordeaux University, ISPED, INSERM U897 CHU de Bordeaux) ;
Dabis, Francois (INSERM U897, Centre Inserm Epidémiologie et Biostatistique, Université de Bordeaux, and Department of Internal Medicine, Bordeaux University Hospital) ;
Moore, Richard R. (School of Medicine, Johns Hopkins University, Baltimore, MD) ;
Reiss, Peter (Stichting HIV Monitoring, Amsterdam, Netherlands; Academic Medical Center, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, and Amsterdam Institute for Global Health and Development) ;
van Sighem, Ard (Stichting HIV Monitoring, Amsterdam, Netherlands) ;
Mathews, William C. (Internal Medicine, Johns Hopkins University) ;
Del Amo, Julia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Deeks, Steven G. (Positive Health Program, San Francisco General Hospital) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. (Fenway Health) ;
Ferrer, Elena (Institut d'Investigació Biomèdica de Bellvitge) ;
Eron, Joseph J. (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Napravnik, Sonia (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Jose, Sophie (University College London) ;
Phillips, Andrew (University College London, London, United Kingdom) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London) ;
Justice, Amy C. (VA Connecticut Healthcare System) ;
Tate, Janet P. (VA Connecticut Healthcare System) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Egger, Matthias (University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland) ;
Touloumi, Giota (Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School) ;
Sterne, Jonathan A. (School of Social and Community Medicine, University of Bristol) ;
Costagliola, Dominique (Institute Pierre Louis d'Épidémiologie et de Santé Publique) ;
Saag, Michael (Department of Medicine, University of Alabama at Birmingham) ;
Hernán, Miguel A. (Department of Medicine, University of Alabama at Birmingham) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). [...]
2016 - 10.1097/QAI.0000000000000956
Journal of acquired immune deficiency syndromes (1999), Vol. 72 (may 2016) , p. 214-221
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