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7 p, 227.7 KB |
Delayed antibiotic prescribing for respiratory tract infections : Protocol of an individual patient data meta-analysis
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Stuart, Beth (University of Southampton) ;
Hounkpatin, Hilda (University of Southampton) ;
Becque, Taeko (University of Southampton) ;
Yao, Guiqing (University of Leicester) ;
Zhu, Shihua (University of Southampton) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Altiner, Attila (University of Rostock) ;
Arroll, Bruce (University of Auckland) ;
Böhning, Dankmar (University of Southampton) ;
Bostock, Jennifer (King's College London) ;
Bucher, Heiner (University of Basel) ;
De La Poza, Mariam (Institut Català de la Salut) ;
Francis, Nick A. (Cardiff University) ;
Gillespie, David (Cardiff University) ;
Hay, Alastair D. (University of Bristol) ;
Kenealy, Timothy (University of Auckland) ;
Löffler, Christin (Rostock University Medical Center) ;
Mas Dalmau, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz, Laura (Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)) ;
Samuel, Kirsty (University of Leeds) ;
Moore, Michael (University of Southampton) ;
Little, Paul (University of Southampton) ;
Universitat Autònoma de Barcelona
Delayed prescribing can be a useful strategy to reduce antibiotic prescribing, but it is not clear for whom delayed prescribing might be effective. This protocol outlines an individual patient data (IPD) meta-analysis of randomised controlled trials (RCTs) and observational cohort studies to explore the overall effect of delayed prescribing and identify key patient characteristics that are associated with efficacy of delayed prescribing. [...]
2019 -  10.1136/bmjopen-2018-026925
BMJ open, Vol. 9 Núm. 1 (january 2019) , p. e026925
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11 p, 299.2 KB |
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes : A prospective study of HIV-positive individuals
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Cain, Lauren E. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Caniglia, Ellen C. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Phillips, Andrew (University College London) ;
Olson, Ashley ;
Muga, Roberto (Institut Germans Trias i Pujol) ;
Pérez Hoyos, Santiago ;
Abgrall, Sophie ;
Costagliola, Dominique ;
Rubio, Rafael ;
Jarrín, Inma ;
Bucher, Heiner ;
Fehr, Jan ;
van Sighem, Ard ;
Reiss, Peter ;
Dabis, François ;
Vandenhende, Marie-Anne ;
Logan, Roger ;
Robins, James ;
Sterne, Jonathan A C ;
Justice, Amy ;
Tate, Janet ;
Touloumi, Giota ;
Paparizos, Vasilis ;
Esteve, Anna ;
Casabona-Barbarà, Jordi ;
Seng, Rémonie ;
Meyer, Laurence ;
Jose, Sophie ;
Sabin, Caroline A ;
Hernán, Miguel A ;
HIV CAUSAL Collaboration ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective: To compare regimens consisting of either ritonavir-boosted atazanavir or efavirenz and a nucleoside reverse transcriptase inhibitor (NRTI) backbone with respect to clinical, immunologic, and virologic outcomes. [...]
2016 - 10.1097/MD.0000000000005133
Medicine, Vol. 95 Núm. 41 (2016) , art. e5133
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3.
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16 p, 711.5 KB |
Delayed antibiotic prescribing for respiratory tract infections : Individual patient data meta-analysis
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Stuart, Beth L. (University of Southampton (Regne Unit). Faculty of Medicine) ;
Hounkpatin, Hilda Osafo (University of Southampton (Regne Unit). Faculty of Medicine) ;
Becque, Taeko (University of Southampton (Regne Unit). Faculty of Medicine) ;
Yao, Guiqing Lily (University of Leicester (Regne Unit). College of Life Sciences) ;
Zhu, Shihua (University of Southampton (Regne Unit). Faculty of Medicine) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Altiner, Attila (Rostock University Medical Center (Alemanya). Institute of General Practice) ;
Arroll, Bruce (University of Auckland (Nova Zelanda). Department of General Practice and Primary Health Care) ;
Böhning, Dankmar (University of Southampton (Regne Unit). Southampton Statistical Sciences Research Institute) ;
Bostock, Jennifer (King's College London (Regne Unit)) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Chao, Jennifer H. (State University of New York Downstate (Nova York)) ;
de la Poza Abad, Mariam (Institut Català de la Salut) ;
Francis, Nick (University of Southampton (Regne Unit). Faculty of Medicine) ;
Gillespie, David C. (Cardiff University (Regne Unit). School of Medicine) ;
Hay, Alastair D. (University of Bristol (Regne Unit). Bristol Medical School) ;
Kenealy, Timothy (University of Auckland (Nova Zelanda). Department of General Practice and Primary Health Care) ;
Löffler, Christin (Rostock University Medical Center (Alemanya). Institute of General Practice) ;
McCormick, David P. (University of Texas Medical Branch at Galveston (Estats Units). Department of Pediatrics) ;
Mas Dalmau, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz, Laura (Agència de Qualitat i Avaluació Sanitàries de Catalunya) ;
Samuel, Kirsty (University of Leeds (Regne Unit). Leeds Institute for Health Sciences) ;
Moore, Michael (University of Southampton (Regne Unit). Faculty of Medicine) ;
Little, Paul S. (University of Southampton (Regne Unit). Faculty of Medicine)
AbstractObjective To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. [...]
2021 - 10.1136/bmj.n808
The BMJ, Vol. 373 (april 2021) , p. n808
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8 p, 722.5 KB |
The effectiveness of daclatasvir based therapy in European patients with chronic hepatitis C and advanced liver disease
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Young, Jim (University Hospital Basel (Basilea, Suïssa)) ;
Weis, Nina (Copenhagen University Hospital) ;
Hofer, Harald (Medical University of Vienna) ;
Irving, William (University of Nottingham) ;
Weiland, Ola (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Giostra, Emiliano (Hôpitaux universitaires de Genève) ;
Pascasio, Juan Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Castells, Lluís (Hospital Universitari Vall d'Hebron) ;
Prieto, Martin (Hospital Universitari i Politècnic La Fe (València)) ;
Postema, Roelien (Bristol-Myers Squibb) ;
Lefevre, Cinira (Bristol-Myers Squibb) ;
Evans, David (Bristol-Myers Squibb) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Calleja, Jose Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
There is limited evidence for the effectiveness of daclatasvir in patients whose hepatitis C threatens their life expectancy. The Named Patient Program in Europe included patients with advanced chronic hepatitis C, a life expectancy of less than 12 months and no other treatment options. [...]
2017 - 10.1186/s12879-016-2106-x
BMC Infectious diseases, Vol. 17 (january 2017)
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11 p, 428.7 KB |
Prospective validation of classification of intraoperative adverse events (ClassIntra) : international, multicentre cohort study
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Dell-Kuster, Salome (Department of Clinical Research, University of Basel, Basel, Switzerland) ;
Gomes, Nuno V (Department of Clinical Research, University of Basel, Basel, Switzerland) ;
Gawria, Larsa (Radboud University Medical Centre. Department of Surgery) ;
Aghlmandi, Soheila (University Hospital Basel (Basilea, Suïssa)) ;
Aduse-Poku, Maame (Guy's and St Thomas' NHS Foundation Trust (Regne Unit)) ;
Bissett, Ian (Department of Surgery, University of Auckland, Auckland, New Zealand) ;
Blanc, Catherine (Lausanne University Hospital) ;
Brandt, Christian (Department of Anaesthesiology, Bürgerspital Solothurn, Solothurn, Switzerland) ;
ten Broek, Richard B. (Radboud University Medical Centre. Department of Surgery) ;
Bruppacher, Heinz R. (Department of Anaesthesiology, Schulthess Clinic, Zurich, Switzerland) ;
Clancy, Cillian (Department of Surgery, Tallaght University Hospital, Dublin, Ireland) ;
Delrio, Paolo (Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale" IRCCS, Naples, Italy) ;
Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galanos-Demiris, Konstantinos (Fourth Surgical Department, G Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece) ;
Gecim, I Ethem (Department of Surgery, Ankara University Medical School, Ankara, Turkey) ;
Ghaffari, Shahbaz (Universitätskliniken der MedUni Wien) ;
Gié, Olivier (Lausanne University Hospital) ;
Goebel, Barbara (University Children's Hospital Basel (Basilea, Suïssa)) ;
Hahnloser, Dieter (Lausanne University Hospital) ;
Herbst, Friedrich (Universitätskliniken der MedUni Wien) ;
Orestis, Ioannidis (Fourth Surgical Department, G Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece) ;
Joller, Sonja (University Children's Hospital Basel (Basilea, Suïssa)) ;
Kang, Soojin (Guy's and St Thomas' NHS Foundation Trust (Regne Unit)) ;
Martín, Rocio (Hospital Universitari Vall d'Hebron) ;
Mayr, Johannes (University Children's Hospital Basel (Basilea, Suïssa)) ;
Meier, Sonja (Guy's and St Thomas' NHS Foundation Trust (Regne Unit)) ;
Murugesan, Jothi (University of Sydney, Royal North Shore Hospital, Sydney, Australia) ;
Nally, Deirdre (Department of Surgery, Tallaght University Hospital, Dublin, Ireland) ;
Ozcelik, Menekse (Department of Anaesthesiology, Ankara University Medical School, Ankara, Turkey) ;
Pace, Ugo (Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale" IRCCS, Naples, Italy) ;
Passeri, Michael (Department of Surgery, Carolinas Medical Centre, Charlotte, NC, USA) ;
Rabanser, Simone (Department of Anaesthesiology, Cantonal Hospital Graubünden, Chur, Switzerland) ;
Ranter, Barbara (Department of Vascular Surgery, Medical University of Innsbruck, Innsbruck, Austria) ;
Rega, Daniela (Colorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale" IRCCS, Naples, Italy) ;
Ridgway, Paul F. (Department of Surgery, Tallaght University Hospital, Dublin, Ireland) ;
Rosman, Camiel (Radboud University Medical Centre. Department of Surgery) ;
Schmid, Roger (Department of Surgery, Bürgerspital Solothurn, Solothurn, Switzerland) ;
Schumacher, Philippe (Department of Anaesthesiology, Bürgerspital Solothurn, Solothurn, Switzerland) ;
Solis-Pena, Alejandro (Hospital Universitari Vall d'Hebron) ;
Villarino, Laura (Hospital Universitari Vall d'Hebron) ;
Vrochides, Dionisios (Department of Surgery, Carolinas Medical Centre, Charlotte, NC, USA) ;
Engel, Alexander (University of Sydney, Royal North Shore Hospital, Sydney, Australia) ;
O'Grady, Greg (Department of Surgery, University of Auckland, Auckland, New Zealand) ;
Loveday, Benjamin (Department of Surgery, University of Auckland, Auckland, New Zealand) ;
Steiner, Luzius A. (Department of Clinical Research, University of Basel, Basel, Switzerland) ;
Van Goor, Harry (Radboud University Medical Centre. Department of Surgery) ;
Bucher, Heiner (Department of Clinical Research, University of Basel, Basel, Switzerland) ;
Clavien, Pierre-Alain (University Hospital Zurich (Suïssa)) ;
Kirchhoff, Philipp (University Hospital Basel (Basilea, Suïssa)) ;
Rosenthal, Rachel (Medical Faculty, University of Basel, Basel, Switzerland) ;
Universitat Autònoma de Barcelona
To prospectively assess the construct and criterion validity of ClassIntra version 1. 0, a newly developed classification for assessing intraoperative adverse events. International, multicentre cohort study. [...]
2020 - 10.1136/bmj.m2917
The BMJ, Vol. 370 (august 2020)
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18 p, 347.2 KB |
Comparing dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals on cART : a prospective observational study in high-income countries
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Caniglia, Ellen C (Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.) ;
Cain, Lauren E. ;
Sabin, Caroline A. ;
Robins, James M. ;
Logan, Roger ;
Abgrall, Sophie ;
Mugavero, Michael J. ;
Hernández-Díaz, Sonia ;
Meyer, Laurence ;
Seng, Remonie ;
Drozd, Daniel R. ;
Seage, George R. ;
Dabis, Francois ;
Fabrice, Bonnet ;
Richard, D. Moore ;
Reiss, Peter ;
van Sighem, Ard ;
Mathews, William C. ;
Del Amo, Julia ;
Moreno, Santiago ;
Deeks, Steven G. ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. ;
Ferrer, Elena ;
Eron, Joseph J. ;
Napravnik, Sonia ;
Jose, Sophie ;
Phillips, Andrew ;
Justice, Amy C. ;
Tate, Janet P. ;
Gill, John ;
Pacheco, Antonio ;
Veloso, Valdilea G. ;
Bucher, Heiner ;
Egger, Matthias ;
Furrer, Hansjakob ;
Kholoud, Porter ;
Touloumi, Giota ;
Crane, Heidi ;
Miró, José M ;
Sterne, Jonathan A. ;
Dominique, Costagliola ;
Saag, Michael ;
Hernán, Miguel A.
Clinical guidelines vary with respect to the optimal monitoring frequency of HIV-positive individuals. We compared dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals. [...]
2017 - 10.1016/S2352-3018(17)30043-7
The lancet. HIV, Vol. 4 (april 2017) , p. e251-e259
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9 p, 319.8 KB |
Limiting Cumulative HIV Viremia Copy-Years by Early Treatment Reduces Risk of AIDS and Death
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Olson, Ashley D. (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Walker, A. Sarah (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Suthar, Amitabh B. (South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, South Africa) ;
Sabin, Caroline A. (Department of Infection and Population Health, University College London (UCL), London, United Kingdom) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Jarrín, Inmaculada (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Ford, Deborah (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. Viremia copy-years (VCY), a time-updated measure of cumulative HIV exposure, predicts AIDS/death; although its utility in deciding when to start combination antiretroviral therapy (cART) remains unclear. [...]
2016 - 10.1097/QAI.0000000000001029
Journal of acquired immune deficiency syndromes (1999), Vol. 73 (august 2016) , p. 100-108
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8 p, 283.7 KB |
When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries : A Prospective Observational Study
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Caniglia, Ellen C. (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA) ;
Sabin, Caroline A. (University College London, London, United Kingdom) ;
Robins, James M. (Department of Biostatistics, Harvard T.H. Chan School of Public Health) ;
Logan, Roger (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Cain, Lauren E. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Abgrall, Sophie (Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Antoine Béclère, Service de Médecine Interne) ;
Mugavero, Michael J. (University of Alabama at Birmingham) ;
Hernandez-Diaz, Sonia (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Meyer, Laurence (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Seng, Remonie (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Drozd, Daniel R. (Division of Allergy and Infectious Diseases, School of Medicine, University of Washington) ;
Seage, George R. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Bonnet, Fabrice (Bordeaux University, ISPED, INSERM U897 CHU de Bordeaux) ;
Dabis, Francois (INSERM U897, Centre Inserm Epidémiologie et Biostatistique, Université de Bordeaux, and Department of Internal Medicine, Bordeaux University Hospital) ;
Moore, Richard R. (School of Medicine, Johns Hopkins University, Baltimore, MD) ;
Reiss, Peter (Stichting HIV Monitoring, Amsterdam, Netherlands; Academic Medical Center, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, and Amsterdam Institute for Global Health and Development) ;
van Sighem, Ard (Stichting HIV Monitoring, Amsterdam, Netherlands) ;
Mathews, William C. (Internal Medicine, Johns Hopkins University) ;
Del Amo, Julia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Deeks, Steven G. (Positive Health Program, San Francisco General Hospital) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. (Fenway Health) ;
Ferrer, Elena (Institut d'Investigació Biomèdica de Bellvitge) ;
Eron, Joseph J. (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Napravnik, Sonia (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Jose, Sophie (University College London) ;
Phillips, Andrew (University College London, London, United Kingdom) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London) ;
Justice, Amy C. (VA Connecticut Healthcare System) ;
Tate, Janet P. (VA Connecticut Healthcare System) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Egger, Matthias (University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland) ;
Touloumi, Giota (Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School) ;
Sterne, Jonathan A. (School of Social and Community Medicine, University of Bristol) ;
Costagliola, Dominique (Institute Pierre Louis d'Épidémiologie et de Santé Publique) ;
Saag, Michael (Department of Medicine, University of Alabama at Birmingham) ;
Hernán, Miguel A. (Department of Medicine, University of Alabama at Birmingham) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). [...]
2016 - 10.1097/QAI.0000000000000956
Journal of acquired immune deficiency syndromes (1999), Vol. 72 (may 2016) , p. 214-221
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