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1.
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13 p, 819.4 KB |
Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Berardinelli, Diletta (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Malaca, Sara (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Huestis, Marilyn A. (Thomas Jefferson University) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50-200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. [...]
2022 -  10.3390/ijms232314636
International journal of molecular sciences, Vol. 23 (november 2022)
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2.
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9 p, 771.4 KB |
Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans
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Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Istituto Superiore di Sanità) ;
Varì, Maria Rosaria (Instituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Zaami, Simona (Università La Sapienza) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. [...]
2023 - 10.3390/ijms24087395
International journal of molecular sciences, Vol. 24 (april 2023)
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3.
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12 p, 1.5 MB |
Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites : Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH
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Sprega, Giorgia (Università Politecnica delle Marche) ;
Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tini, Anastasio (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers participated after ingestion of 50, 100, 150 and 200 mg of methylone. [...]
2023 - 10.3390/metabo13040468
Metabolites, Vol. 13 (march 2023)
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4.
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13 p, 1.4 MB |
Pharmacological effects of methylone and MDMA in humans
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Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Núñez-Montero, Melani (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de la Rosa, Georgina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martín, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barriocanal, Ana María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carabias, Lydia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kelmendi, Benjamin (Yale University School of Medicine. Department of Psychiatry) ;
Taoussi, Omayema (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Fonseca, Francina 1972- (Institut de Neuropsiquiatria i Adiccions (Barcelona)) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Pichini, Simona (Istituto Superiore di Sanità. National Centre on Addiction and Doping (Itàlia)) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i. [...]
2023 - 10.3389/fphar.2023.1122861
Frontiers in Pharmacology, Vol. 14 (february 2023)
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5.
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9 p, 1.2 MB |
Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis
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Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Italy) ;
Pacifici, Roberta (Istituto Superiore di Sanità, Rome, Italy) ;
Mannocchi, Giulio (University of Camerino, Italy) ;
Gottardi, Massimo (Comedical srl, Trento, Italy) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Università Politecnica delle Marche, Ancona, Italy) ;
Pichini, Simona (Istituto Superiore di Sanità, Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
The use of cannabis flowering tops with standardized amounts of active phytocannabinoids was recently authorized in several countries to treat several painful pathological conditions. The acute pharmacological effects and disposition of Δ-9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors and THC metabolites after oil and decoction administration have been already described. [...]
2020 - 10.3390/ph13120459
Pharmaceuticals, Vol. 13 (december 2020)
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6.
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14 p, 1.3 MB |
Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS
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La Maida, Nunzia (University "Politecnica delle Marche" of Ancona) ;
Pellegrini, Manuela (National Centre on Addiction and Doping, Rome) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Energy Control, Associació Benestar i Desenvolupament) ;
Galindo, Liliana (Energy Control, Associació Benestar i Desenvolupament) ;
Busardo, Francesco Paolo (University "Politecnica delle Marche" of Ancona) ;
Pichini, Simona (National Centre on Addiction and Doping, Rome) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Marchei, Emilia (National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.Le Regina Elena 299, 00161 Rome, Italy; (S.P.); (E.M.))
The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. [...]
2020 - 10.3390/ijms21249414
International journal of molecular sciences, Vol. 21 (december 2020)
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7.
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14 p, 991.2 KB |
Acute Pharmacological Effects and Oral Fluid Biomarkers of the Synthetic Cannabinoid UR-144 and THC in Recreational Users
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Maida, Nunzia La (Università Politecnica delle Marche (Ancona, Itàlia). Department of Excellence of Biomedical Science and Public Health) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martínez, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pellegrini, Manuela (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Pichini, Simona (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Pacifici, Roberta (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Ventura, Mireia (Associació Benestar i Desenvolupament (Barcelona)) ;
Galindo, Liliana (Associació Benestar i Desenvolupament (Barcelona)) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche (Ancona, Itàlia). Department of Excellence of Biomedical Science and Public Health) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
UR-144 is a synthetic cannabinoid found in herbal incenses for recreational use as a substitute of cannabis. It is a cannabinoid receptor agonist with effects on the central nervous system similar to those of THC. [...]
2021 - 10.3390/biology10040257
Biology, Vol. 10 Núm. 4 (march 2021)
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8.
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14 p, 1.5 MB |
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
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Busardo, Francesco Paolo (Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pacifici, Roberta (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Mannocchi, Giulio (School of Law, University of Camerino, 62032 Camerino, Italy) ;
Gottardi, Massimo (Comedical S.Rl, 38123 Trento, Italy) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pichini, Simona (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. [...]
2021 - 10.3390/ph14010059
Pharmaceuticals, Vol. 14 (january 2021)
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9.
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21 p, 893.8 KB |
Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations : A Systematic Review
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Siles, Adrià (Institut Germans Trias i Pujol) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Ancona) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background and objective : Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. [...]
2020 - 10.3390/medicina56060309
Medicina, Vol. 56 (june 2020)
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