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1.
10 p, 391.9 KB Ponesimod Compared with Teriflunomide in Patients with Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study : A Randomized Clinical Trial / Kappos, Ludwig (University of Basel) ; Fox, Robert J. (Cleveland Clinic) ; Burcklen, Michel (Actelion Pharmaceuticals) ; Freedman, Mark S. (University of Ottawa) ; Kubala Havrdova, Eva (Charles University) ; Hennessy, Brian (Actelion Pharmaceuticals) ; Hohlfeld, Reinhard (Ludwig Maximilians University Munich) ; Lublin, Fred (Icahn School of Medicine at Mount Sinai) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron) ; Pozzilli, Carlo (Sapienza University of Rome) ; Scherz, Tatiana (Actelion Pharmaceuticals) ; D'Ambrosio, Daniele (Galapagos GmbH) ; Linscheid, Philippe (Actelion Pharmaceuticals) ; Vaclavkova, Andrea (Actelion Pharmaceuticals) ; Pirozek-Lawniczek, Magdalena (Actelion Pharmaceuticals) ; Kracker, Hilke (Actelion Pharmaceuticals) ; Sprenger, Till (University of Basel) ; Universitat Autònoma de Barcelona
Importance: To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease-modifying therapies for relapsing multiple sclerosis (RMS). [...]
2021 - 10.1001/jamaneurol.2021.0405
JAMA Neurology, Vol. 78 Núm. 5 (may 2021) , p. 558-567  
Registre complet - Creative Commons
2.
13 p, 1.3 MB Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal / Thompson, Alan (University College London) ; Carroll, William ; Ciccarelli, Olga ; Comi, Giancarlo ; Cross, Anne H. ; Donnelly, Alexis A. ; Feinstein, Anthony ; Fox, Robert J ; Helme, Anne ; Hohlfeld, Reinhard ; Hyde, Robert ; Kanellis, Pamela ; Landsman, Douglas ; Lubetzki, Catherine ; Marrie, Ruth Ann ; Morahan, Julia ; Montalban, Xavier (Hospital Universitari Vall d'Hebron) ; Musch, Bruno ; Rawlings, Sarah ; Salvetti, Marco ; Sellebjerg, Finn ; Sincock, Caroline ; Smith, Kathryn E ; Strum, Jon ; Zaratin, Paola ; Coetzee, Timothy ; Universitat Autònoma de Barcelona
Progressive forms of multiple sclerosis (MS) affect more than 1 million individuals globally. Recent approvals of ocrelizumab for primary progressive MS and siponimod for active secondary progressive MS have opened the therapeutic door, though results from early trials of neuroprotective agents have been mixed. [...]
2021 - 10.1177/13524585211059766
Multiple sclerosis, Vol. 28 (december 2021) , p. 16-28  
Registre complet - Creative Commons

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