Resultats globals: 6 registres trobats en 0.02 segons.
Articles, 6 registres trobats
Articles 6 registres trobats  
1.
33 p, 8.1 MB Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis / Cavalcanti, Fernando (Oryzon Genomics S.A) ; Gonzalez-Rey, Elena (Instituto de Parasitología y Biomedicina "López-Neyra") ; Delgado, Mario (Instituto de Parasitología y Biomedicina "López-Neyra") ; Falo, Clara P. (Instituto de Parasitología y Biomedicina "López-Neyra") ; Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; O'Valle, Francisco (Univeridad de Granada. Departamento de Patologia) ; Lufino, Michele M. P. (Oryzon Genomics S.A) ; Xaus, Jordi (Oryzon Genomics S.A) ; Mascaró, Cristina (Oryzon Genomics S.A) ; Lunardi, Serena (Oryzon Genomics S.A) ; Sacilotto, Natalia (Oryzon Genomics S.A) ; Dessanti, Paola (Oryzon Genomics S.A) ; Rotllant, David (Oryzon Genomics S.A) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Buesa, Carlos (Oryzon Genomics S.A) ; Maes, Tamara (Oryzon Genomics S.A)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of diseases such as cancer, central nervous system (CNS) disorders, viral infections, and others. [...]
2022 - 10.3390/pharmaceutics14071420
Pharmaceutics, Vol. 14 Núm. 7 (2022) , p. 1420  
2.
11 p, 2.5 MB Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE / Marín, Nieves (Red Española de Esclerosis Múltiple) ; Mecha, Miriam (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Espejo, Carmen (Universitat Autònoma de Barcelona) ; Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Eixarch, Herena (Universitat Autònoma de Barcelona) ; Montalban, Xavier (Universitat Autònoma de Barcelona) ; Alvarez-Cermeño, José C (Universidad de Alcalá) ; Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Villar, Luisa M. (Red Española de Esclerosis Múltiple)
Background and Objectives. Resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis (EAE), an inducible demyelinating experimental disease serving as animal model for multiple sclerosis, have been described. [...]
2014 - 10.1155/2014/156380
Journal of Immunology Research, Vol. 2014 (april 2014)  
3.
16 p, 2.6 MB Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus / Carrillo-Salinas, Francisco J (Red Española de Esclerosis Múltiple) ; Mestre, L. (Red Española de Esclerosis Múltiple) ; Mecha, Miriam (Red Española de Esclerosis Múltiple) ; Feliú, Ana (Red Española de Esclerosis Múltiple) ; del Campo, Rosa (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Villarrubia, Noelia (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alvarez-Cermeño, José C (Universidad de Alcalá) ; Villar, L. M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Guaza, C. (Red Española de Esclerosis Múltiple) ; Universitat Autònoma de Barcelona
Recent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. [...]
2017 - 10.1038/srep44377
Scientific reports, Vol. 7 (03 2017)  
4.
18 p, 6.7 MB Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis / Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cornejo-Sánchez, Thais (Hospital Universitari Vall d'Hebron) ; Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castillo, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mestre, Leyre (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Guaza, Carmen (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Martínez-Cuesta, María del Carmen (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Investigación en Ciencias de la Alimentación) ; Tanoue, Takeshi (RIKEN Center for Integrative Medical Sciences) ; Honda, Kenya (RIKEN Center for Integrative Medical Sciences) ; González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a signifcant decrease of Clostridia cluster IV and XIVa has been reported. [...]
2021 - 10.1007/s13311-021-01016-7
Neurotherapeutics, Vol. 18 (april 2021) , p. 920-937  
5.
7.8 MB How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process / Mestre, Leyre (Red Española de Esclerosis Múltiple (REEM)) ; Carrillo-Salinas, Francisco J. (Tufts University School of Medicine) ; Feliú, Ana (Red Española de Esclerosis Múltiple (REEM)) ; Mecha, Miriam (Red Española de Esclerosis Múltiple (REEM)) ; Alonso, Graciela (Red Española de Esclerosis Múltiple (REEM)) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Luque-García, José L. (Complutense University of Madrid) ; Estevez, Héctor (Complutense University of Madrid) ; Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Guaza, Carmen (Red Española de Esclerosis Múltiple (REEM)) ; Universitat Autònoma de Barcelona
A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the pathophysiology of MS. Several studies have reported alterations in the gut microbiome of MS patients. [...]
2020 - 10.1080/19490976.2020.1813532
Gut Microbes, Vol. 12 (september 2020)  
6.
18 p, 3.0 MB Manipulation of gut microbiota influences immune responses, axon preservation, and motor disability in a model of progressive multiple sclerosis / Mestre, Leyre (Red Española de Esclerosis Múltiple (REEM)) ; Carrillo-Salinas, Francisco J (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ; Mecha, Miriam (Red Española de Esclerosis Múltiple (REEM)) ; Feliú, Ana (Red Española de Esclerosis Múltiple (REEM)) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Villar, L. M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Guaza, C. (Red Española de Esclerosis Múltiple (REEM))
Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we sought to determine whether dysbiosis induced by oral antibiotics (ABX) administered on pre-symptomatic and symptomatic phases of the disease influences its course. [...]
2019 - 10.3389/fimmu.2019.01374
Frontiers in immunology, Vol. 10 Núm. JUN (2019) , p. 1374  

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