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Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset / Homann, Jan (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Osburg, Tim (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Deecke, Laura (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ; Bos, Isabelle (Vrije Universiteit Amsterdam) ; Vandenberghe, Rik (Neurology Service. University Hospital Leuven) ; Gabel, Silvy (Laboratory for Cognitive Neurology. Department of Neurosciences. KU Leuven) ; Scheltens, Philip (Vrije Universiteit Amsterdam) ; Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ; Engelborghs, Sebastiaan (Vrije Universiteit Amsterdam) ; Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Institut Neurosciences Timone. AIX Marseille University) ; Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline RD) ; Bordet, Régis (Lille Neuroscience and Cognition. University of Lille. Inserm. CHU Lille) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ; Clark, Christopher (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zurich) ; Peyratout, Gwendoline (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ; Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ; Dobson, Richard J.B. (NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust) ; Legido-Quigley, Cristina (King's College London. Institute of Pharmaceutical Sciences) ; Sleegers, Kristel (Center for Molecular Neurology) ; Van Broeckhoven, Christine (University of Antwerp) ; Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College London) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Zetterberg, Henrik (University College London. UK Dementia Research Institute) ; Lovestone, Simon (University of Oxford. Department of Psychiatry) ; Streffer, Johannes ; ten Kate, Mara (Amsterdam UMC. University Medical Center) ; Vos, Stephanie J.B. (Maastricht University) ; Barkhof, Frederik (University College London) ; Visser, Pieter Jeller (Karolinska Institutet. Department of Neurobiology) ; Bertram, Lars (University of Oslo)
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. [...]
2022 - DOI (Digital Object Identifier)

10.3389/fnagi.2022.840651
Frontiers in aging neuroscience, Vol. 14 (March 2022) , p. 840651

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