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11 p, 1.8 MB |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
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Klein, Alison P. (Johns Hopkins School of Medicine, Baltimore, USA) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute, Boston, USA) ;
Risch, Harvey A. (Yale School of Public Health, New Haven, USA) ;
Stolzenberg-Solomon, Rachael Z. (National Institutes of Health, Bethesda, USA) ;
Mocci, Evelina (Johns Hopkins School of Medicine, Baltimore, USA) ;
Zhang, Mingfeng (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Canzian, Federico (Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Childs, Erica J. (Johns Hopkins School of Medicine, Baltimore, USA) ;
Hoskins, Jason W. (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Jermusyk, Ashley (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Zhong, Jun (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Chen, Fei (Johns Hopkins School of Medicine, Baltimore, USA) ;
Albanes, Demetrius (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Andreotti, Gabriella (National Institutes of Health, Bethesda, USA) ;
Arslan, Alan A. (New York University School of Medicine, New York, USA) ;
Babic, Ana (Dana-Farber Cancer Institute, Boston, USA) ;
Bamlet, William R. (Mayo Clinic College of Medicine, Rochester, USA) ;
Beane-Freeman, Laura (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
Berndt, Sonja (National Institutes of Health, Bethesda, USA) ;
Blackford, Amanda (Johns Hopkins School of Medicine, Baltimore, USA) ;
Borges, Michael (Johns Hopkins School of Medicine, Baltimore, USA) ;
Borgida, Ayelet (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.) ;
Bracci, Paige M. (University of California, San Francisco, USA) ;
Brais, Lauren (Dana-Farber Cancer Institute, Boston, USA) ;
Brennan, Paul (International Agency for Research on Cancer (IARC), Lyon, France) ;
Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands) ;
Buring, Julie (Division of Preventive Medicine, Brigham and Women's Hospital, Boston) ;
Campa, Daniele (University of Pisa) ;
Capurso, Gabriele (University of Rome) ;
Cavestro, Giulia Martina (Vita-Salute San Raffaele University, Milan) ;
Chaffee, Kari G (Mayo Clinic College of Medicine, Rochester, USA) ;
Chung, Charles C. (National Institutes of Health, Bethesda, USA) ;
Cleary, Sean (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
Cotterchio, Michelle (University of Toronto.) ;
Dijk, Frederike (University of Amsterdam. Department of Pathology, Academic Medical Center) ;
Duell, Eric J. (Institut d'Investigació Biomèdica de Bellvitge) ;
Foretova, Lenka (Masaryk Memorial Cancer Institute. Department of Cancer Epidemiology and Genetics, Brno, Czech Republic.) ;
Fuchs, Charles (Yale Cancer Center, New Haven, USA) ;
Funel, Niccola (University of Pisa.) ;
Gallinger, Steven (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
M. Gaziano, J. Michael (Boston VA Healthcare System) ;
Gazouli, Maria (National and Kapodistrian University of Athens) ;
Giles, Graham G. (Monash University. Department of Epidemiology and Preventive Medicine, Melbourne, Australia) ;
Giovannucci, Edward (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Goggins, Michael (Johns Hopkins School of Medicine. Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Baltimore) ;
Goodman, Gary E. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences, Seattle, USA) ;
Goodman, Phyllis J. (Fred Hutchinson Cancer Research Center. SWOG Statistical Center, Seattle, USA) ;
Hackert, Thilo (University Hospital Heidelberg, Germany) ;
Haiman, Christopher A (University of Southern California, USA) ;
Hartge, Patricia (National Institutes of Health, Bethesda, USA) ;
Hasan, Manal (University of Texas MD Anderson Cancer Center, USA) ;
Hegyi, Peter (University of Szeged, Szeged, Hungary) ;
Helzlsouer, Kathy J. (National Institutes of Health, Bethesda, USA) ;
Herman, Joseph (Johns Hopkins School of Medicine. Baltimore, USA) ;
Holcatova, Ivana (Charles University, Prague, Czech Republic) ;
Holly, Elizabeth A. (University of California, San Francisco) ;
Hoover, Robert (National Institutes of Health, Bethesda, USA) ;
Hung, Rayjean J. (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada) ;
Jacobs, Eric J. (American Cancer Society. Epidemiology Research Program, Atlanta) ;
Jamroziak, Krzysztof (Institute of Hematology and Transfusion Medicine, Warsaw, Poland) ;
Janout, Vladimir (Faculty of Medicine, University of Olomouc, Czech Republic) ;
Kaaks, Rudolf (German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Khaw, Kay-Tee (University of Cambridge) ;
Klein, Eric A. (Cleveland Clinic) ;
Kogevinas, M (Hospital del Mar (Barcelona, Catalunya)) ;
Kooperberg, Charles (Fred Hutchinson Cancer Research Center, Seattle) ;
Kulke, Matthew H. (Dana-Farber Cancer Institute, Boston) ;
Kupcinskas, Juozas (Lithuanian University of Health Sciences, Kaunas, Lithuania) ;
Kurtz, Robert J. (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Laheru, Daniel (Johns Hopkins School of Medicine, Baltimore, USA) ;
Landi, Stefano (University of Pisa) ;
Lawlor, Rita T. (University and Hospital Trust of Verona) ;
Lee, I.-Min (Harvard School of Public Health, Boston) ;
LeMarchand, Loic (University of Hawaii Cancer Center, Honolulu, USA) ;
Lu, Lingeng (Yale School of Public Health, New Haven, USA) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer, Madrid) ;
Mambrini, Andrea (Oncology Department, ASL1 Massa Carrara, Italy) ;
Mannisto, Satu (National Institute for Health and Welfare, Helsinki, Finland) ;
Milne, Roger L. (The University of Melbourne, Australia) ;
Mohelníková-Duchoňová, Beatrice (Palacky University Olomouc and University Hospital, Czech Republic) ;
Neale, Rachel E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Neoptolemos, John P. (University of Heidelburg, Heidelberg, Germany) ;
Oberg, Ann L. (Mayo Clinic College of Medicine, Rochester, USA) ;
Olson, Sara H. (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Orlow, Irene (Memorial Sloan Kettering Cancer Center, New York, USA) ;
Pasquali, Claudio (University of Padua, Italy) ;
Patel, Alpa V. (American Cancer Society, Atlanta) ;
Peters, Ulrike (Fred Hutchinson Cancer Research Center, Seattle) ;
Pezzilli, Raffaele (Sant'Orsola-Malpighi Hospital, Bologna, Italy) ;
Porta, Miquel 1957- (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Real, Francisco X. (Universitat Pompeu Fabra) ;
Rothman, Nathaniel (National Institutes of Health, Bethesda, USA) ;
Scelo, Ghislaine (International Agency for Research on Cancer (IARC), Lyon, France) ;
Sesso, Howard D. (Harvard T.H. Chan School of Public Health. Department of Epidemiology) ;
Severi, Gianluca (Université Paris-Saclay, France) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine, Nashville, USA) ;
Silverman, Debra (National Institutes of Health, Bethesda, USA) ;
Smith, Jill P. (Georgetown University, Washington, USA) ;
Soucek, Pavel (Charles University, Pilsen, Czech Republic.) ;
Sund, Malin (Umeå University, Sweden) ;
Talar-Wojnarowska, Renata (Medical University of Łodz, Poland) ;
Tavano, Francesca (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Italy) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center, Seattle) ;
Tobias, Geoffrey S. (National Institutes of Health, Bethesda, USA) ;
Van Den Eeden, Stephen K. (Kaiser Permanente Northern California, USA) ;
Vashist, Yogesh (University Hamburg-Eppendorf, Germany) ;
Visvanathan, Kala (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA) ;
Vodicka, Pavel (Academy of Sciences of the Czech Republic, Prague, Czech Republic) ;
Wactawski-Wende, Jean (University at Buffalo, USA) ;
Wang, Zhaoming (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ;
Wentzensen, Nicolas (National Cancer Institute, National Institutes of Health, Bethesda, USA) ;
White, Emily (University of Washington, USA) ;
Yu, Herbert (University of Hawaii Cancer Center, USA) ;
Yu, Kai (National Institutes of Health, Bethesda, USA) ;
Zeleniuch-Jacquotte, Anne (New York University School of Medicine, USA) ;
Zheng, Wei (Vanderbilt University School of Medicine, Nashville, USA) ;
Kraft, Peter (Harvard School of Public Health, USA) ;
Li, Donghui (University of Texas MD Anderson Cancer Center, USA) ;
Chanock, Stephen (National Institutes of Health, Bethesda, USA) ;
Obazee, Ofure (German Cancer Research Center (DKFZ), Heidelberg, Germany) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine, Rochester, USA) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica))
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). [...]
2018 -  10.1038/s41467-018-02942-5
Nature communications, Vol. 9 (february 2018)
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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