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11 p, 379.4 KB Postoperative Chemotherapy Use and Outcomes From ADAURA : Osimertinib as Adjuvant Therapy for Resected EGFR-Mutated NSCLC / Wu, Yi-Long (Guangdong Lung Cancer Institute) ; John, Thomas (Austin Health) ; Grohe, Christian (Evangelische Lungenklinik) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Goldman, Jonathan W. (University of California) ; Kim, Sang-We (University of Ulsan) ; Kato, Terufumi (Kanagawa Cancer Center) ; Laktionov, Konstantin (Blokhin National Medical Research Center of Oncology) ; Vu, Huu Vinh (Choray Hospital) ; Wang, Zhije (Chinese Academy of Medical Sciences) ; Lu, Shun (Shanghai Jiao Tong University) ; Lee, Kye Young (Konkuk University Medical Center) ; Akewanlop, Charuwan (Siriraj Hospital) ; Yu, Chong-Jen (National Taiwan University College of Medicine) ; de Marinis, Filippo (European Institute of Oncology) ; Bonanno, Laura (Istituto Oncologico Veneto) ; Domine, Manuel (Instituto de Investigación Sanitaria-Fundación Jiménez Díaz) ; Shepherd, Frances A. (University of Toronto) ; Zeng, Lingmin (AstraZeneca) ; Atasoy, Ajlan (AstraZeneca) ; Herbst, Roy S. (Yale School of Medicine) ; Tsuboi, Masahiro (National Cancer Center Hospital East) ; Universitat Autònoma de Barcelona
Introduction: Adjuvant chemotherapy is recommended in patients with resected stages II to IIIA (and select IB) NSCLC; however, recurrence rates are high. In the phase 3 ADAURA study (NCT02511106), osimertinib was found to have a clinically meaningful improvement in disease-free survival (DFS) in patients with resected stages IB to IIIA EGFR-mutated (EGFRm) NSCLC. [...]
2022 - 10.1016/j.jtho.2021.10.014
Journal of Thoracic Oncology, Vol. 17 Núm. 3 (march 2022) , p. 423-433  
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