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12 p, 613.3 KB |
One-Step Nucleic Acid Amplification (OSNA) of Sentinel Lymph Node in Early-Stage Endometrial Cancer : Spanish Multicenter Study (ENDO-OSNA)
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Diestro, María Dolores (Hospital Universitario La Paz (Madrid)) ;
Berjón, Alberto (Hospital Universitario La Paz (Madrid)) ;
Zapardiel, Ignacio (Hospital Universitario La Paz (Madrid)) ;
Yébenes, Laura (Hospital Universitario La Paz (Madrid)) ;
Ruiz, Irune (Hospital Universitario Donostia Osakidetza) ;
Lekuona, Arantza (Hospital Universitario Donostia Osakidetza) ;
Rezola, Marta (Hospital Universitario Donostia Osakidetza) ;
Jaunarena, Ibon (Hospital Universitario Donostia Osakidetza) ;
Siegrist, Jaime (Hospital Universitario La Paz (Madrid)) ;
Sánchez-Pastor, Margarita (Hospital Universitario La Paz (Madrid)) ;
Cuadra, María (OSI Araba Hospital Universitario) ;
Sagasta, Amaia (OSI Araba Hospital Universitario) ;
Guerra, Isabel (OSI Araba Hospital Universitario) ;
Lete, Luis I. (OSI Araba Hospital Universitario) ;
Roldán, Fernando (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Marta, Carlo B. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Boillos, María J. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Cardiel, María J. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
López-de la Manzanara, Carlos (Hospital General Universitario Ciudad Real) ;
Relea, Fernanda (Hospital General Universitario Ciudad Real) ;
Coronado, Pluvio (Hospital Clínico San Carlos (Madrid)) ;
Pascual, Alejandro (Hospital Clínico San Carlos (Madrid)) ;
Román, María J. (Hospital General Universitari Dr. Balmis) ;
Peiró, Gloria (Hospital General Universitari Dr. Balmis) ;
Matute, Luis J. (Hospital Universitari i Politècnic La Fe (València)) ;
Montero, Beatriz (Hospital Universitari i Politècnic La Fe (València)) ;
Muruzábal, Juan C. (Complejo Hospitalario Universitario Navarra) ;
Guarch, Rosa (Complejo Hospitalario Universitario Navarra) ;
Zorrero, Cristina (Hospital Fundación IVO) ;
Calatrava, Ana (Hospital Fundación IVO, 46009 Valencia) ;
Ribot, Laia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Costa, Irmgard (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Hernández Gutierrez, Alicia (Hospital Universitario La Paz (Madrid)) ;
Hardisson, David (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
One-step nucleic acid amplification (OSNA) is an automated molecular diagnostic assay used to detect metastases by analyzing the levels of cytokeratin 19 mRNA in whole lymph nodes. It has been validated as an accurate and reliable tool for staging in several types of cancers and is included in the National Institute for Health and Care Excellence guidelines for the management of breast cancer. [...]
2021 -  10.3390/cancers13174465
Cancers, Vol. 13 (september 2021)
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2.
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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 - 10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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3.
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15 p, 1.9 MB |
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer
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Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Dittmar, Gunnar (Luxembourg Institute of Health) ;
Nazarov, Petr V. (Luxembourg Institute of Health) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) mortality is directly associated with the presence of poor prognostic factors. Molecular prognostic factors have been identified, but none are used in clinical practice due to lack of validation studies. [...]
2021 - 10.3390/cancers13205052
Cancers, Vol. 13 (october 2021)
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4.
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre de Regulació Genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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5.
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12 p, 886.3 KB |
Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC) : Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group
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Oliver-Perez, M. Reyes (Hospital Universitario 12 de Octubre (Madrid)) ;
Padilla-Iserte, Pablo (Hospital Universitari i Politècnic La Fe (València)) ;
Arencibia-Sanchez, Octavio (Department of Gynecologic Oncology, University Hospital Materno-Infantil de Canarias) ;
Martin-Arriscado, Cristina (Hospital Universitario 12 de Octubre (Madrid)) ;
Muruzabal, Juan Carlos (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Díaz-Feijoo, Berta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Coronado, Pluvio (Complutense University Madrid) ;
Martín-Salamanca, M. Belen (Department of Gynecology, Hospital Universitario de Getafe) ;
Pantoja-Garrido, Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Marcos-Sanmartin, Josefa (Institute for Health and Biomedical Research) ;
Cabezas-López, Elena (Department of Gynecologic Oncology, University Hospital Ramón y Cajal) ;
Lorenzo, Cristina (Department of Obstetrics and Gynecology, Hospital Nuestra Señora de la Calendaria) ;
Beric, Duska (Department of Obstetrics and Gynecology, Hospital Universitario de Torrevieja) ;
Rodriguez-Hernandez, Jose Ramon (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Roldan-Rivas, Fernando (Department of Obstetrics and Gynaecology, Clinico Lozano Blesa Hospita) ;
Gilabert-Estelles, Juan (Department of Pediatrics, Obstetrics and Gynecology, University General Hospital of Valencia) ;
Sanchez, Lourdes (Department of Gynecology and Obstetrics, University General Hospital of Ciudad Real) ;
Laseca-Modrego, Maria (Department of Gynecologic Oncology, University Hospital Materno-Infantil de Canarias) ;
Tauste-Rubio, Carmen (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Gil-Ibañez, Blanca (Hospital Universitario 12 de Octubre (Madrid)) ;
Tejerizo-Garcia, Alvaro (Hospital Universitario 12 de Octubre (Madrid)) ;
Universitat Autònoma de Barcelona
In patients with early-stage endometrioid endometrial cancer, the presence of lymph vascular space involvement (LVSI) correlates with nodal metastases, shorter disease-free survival and overall survival. [...]
2023 - 10.3390/cancers15092612
Cancers, Vol. 15 (may 2023)
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13 p, 1.4 MB |
Neural plasticity of the uterus : New targets for endometrial cancer?
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Español, Pia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Luna-Guibourg, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Soler, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Caruana, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Altés-Arranz, Amanda (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rodríguez-Lozano, Francisco (Institut d'Investigació Biomèdica Sant Pau) ;
Porta, Oriol (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sanchez-Garcia, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Llurba, E (Institut d'Investigació Biomèdica Sant Pau) ;
Rovira Negre, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Endometrial carcinoma is the most common gynecological malignancy in Western countries and is expected to increase in the following years because of the high index of obesity in the population. Recently, neural signaling has been recognized as part of the tumor microenvironment, playing an active role in tumor progression and invasion of different solid tumor types. [...]
2022 - 10.1177/17455057221095537
Women's Health, Vol. 18 (april 2022)
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7.
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17 p, 2.5 MB |
Cervical Fluids Are a Source of Protein Biomarkers for Early, Non-Invasive Endometrial Cancer Diagnosis
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Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lesur, Antoine (Luxembourg Institute of Health) ;
Dittmar, Gunnar (University of Luxembourge) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Abnormal uterine bleeding (AUB) is the main symptom of endometrial cancer (EC), but it is highly nonspecific. This represents a huge burden for women's health, since all women presenting with bleeding will undergo sequential invasive tests, avoidable in 90-95% of those women who do not have EC. [...]
2023 - 10.3390/cancers15030911
Cancers, Vol. 15 (january 2023)
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20 p, 10.3 MB |
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival
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Diéguez-Martínez, Nora (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Espinosa-Gil, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Yoldi Salinas, Guillermo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Megías-Roda, Elisabet (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bolinaga-Ayala, Idoia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Viñas-Casas, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Gorgisen, Gokhan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Domingo-Ortí, Inés (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Montoyo, Héctor (Ability Pharmaceuticals (Cerdanyola del Vallès)) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dolcet, Xavier (Universitat de Lleida) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Endometrial cancer (EC) is the most common type of gynecologic cancer in women of developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival of patients with high-risk EC tumors is poor, indicating a need for novel therapies. [...]
2022 - 10.1007/s00018-022-04541-6
Cellular and Molecular Life Sciences, Vol. 79 (2022) , p. 524
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9.
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16 p, 1.6 MB |
Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors : Results of Efficacy, Tolerability, and the Translational Study
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Poveda, Andres (Hospital Quironsalud (Valencia). Oncogynecologic Department) ;
Lopez-Reig, Raquel (Fundació Institut Valencià d'Oncologia) ;
Oaknin, Ana (Vall d'Hebron Institut d'Oncologia) ;
Redondo, Andres (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rubio, Maria Jesus (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Guerra, Eva (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fariñas-Madrid, Lorena (Vall d'Hebron Institut d'Oncologia) ;
Gallego, Alejandro (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rodriguez-Freixinos, Victor (Vall d'Hebron Institut d'Oncologia) ;
Fernandez-Serra, Antonio (Fundació Institut Valencià d'Oncologia) ;
Juan, Óscar (Pivotal SLU (Madrid)) ;
Romero, Ignacio (Fundació Institut Valencià d'Oncologia) ;
López-Guerrero, J.A (Fundació Institut Valencià d'Oncologia)
Genomic instability (GI) is a transversal phenomenon in oncology, constituting a hallmark of cancer. In gynecological malignancies, the predictive value of GI has been described and is mainly caused by alterations in the homologous recombination repair (HRR) genes, such as BRCA1/2. [...]
2022 - 10.3390/cancers14040915
Cancers, Vol. 14 Núm. 4 (february 2022)
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10.
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26 p, 789.4 KB |
Small-Molecule Inhibitors (SMIs) as an Effective Therapeutic Strategy for Endometrial Cancer
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Megino-Luque, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Molins-Escuder, Clara (Universitat de Lleida) ;
López-Gil, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eritja, Núria (Institut de Recerca Biomèdica de Lleida) ;
Universitat Autònoma de Barcelona
Patients diagnosed with endometrial cancer (EC), the most common gynaecological malignancy in women worldwide, cope with a disease associated with poor prognosis and limited treatment options after first-line therapy when it reaches an advanced or metastatic stage. [...]
2020 - 10.3390/cancers12102751
Cancers, Vol. 12 (september 2020)
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