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21 p, 2.8 MB |
Systemic Oncological Treatments versus Supportive Care for Patients with Advanced Hepatobiliary Cancers : An Overview of Systematic Reviews
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Bracchiglione, Javier (Institut de Recerca Sant Pau) ;
Rodríguez-Grijalva, Gerardo (Iberoamerican Cochrane Centre) ;
Requeijo, Carolina (Institut de Recerca Sant Pau) ;
Santero, Marilina (Institut de Recerca Sant Pau) ;
Salazar, Josefina (Institut de Recerca Sant Pau) ;
Salas-Gama, Karla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Meade, Adriana-Gabriela (Iberoamerican Cochrane Centre) ;
Antequera, Alba (Iberoamerican Cochrane Centre) ;
Auladell-Rispau, Ariadna (Iberoamerican Cochrane Centre) ;
Quintana Ruiz, Maria Jesús (Institut de Recerca Sant Pau) ;
Solà, Ivan (Institut de Recerca Sant Pau) ;
Urrútia, Gerard (Institut de Recerca Sant Pau) ;
Acosta-Dighero, Roberto (Interdisciplinary Centre for Health Studies (CIESAL), Universidad de Valparaíso, Viña del Mar 46383, Chile) ;
Bonfill, X. (Xavier) (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona
Hepatobiliary cancers (that include hepatocellular carcinoma, intrahepatic or extrahepatic cholangiocarcinoma and gallbladder cancer) are usually treated with systemic oncological treatments (i. e. , chemotherapy, immunotherapy and biological or targeted therapies) mainly due to their improvement in survival. [...]
2023 - 10.3390/cancers15030766
Cancers, Vol. 15 (january 2023)
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3.
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18 p, 2.6 MB |
Efficacy of systemic oncological treatments in patients with advanced esophageal or gastric cancers at high risk of dying in the middle and short term : an overview of systematic reviews
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Santero, Marilina (Institut d'Investigació Biomèdica Sant Pau) ;
Bracchiglione, Javier (Universidad de Valparaíso) ;
Acosta-Dighero, Roberto (Universidad San Sebastian) ;
Meade, Adriana-Gabriela (Institut d'Investigació Biomèdica Sant Pau) ;
Antequera, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Auladell-Rispau, Ariadna (Institut d'Investigació Biomèdica Sant Pau) ;
Quintana Ruiz, Maria Jesús (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Requeijo, Carolina (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez-Grijalva, G. (Institut d'Investigació Biomèdica Sant Pau) ;
Salas-Gama, Karla (Institut d'Investigació Biomèdica Sant Pau) ;
Dorantes-Romandia, R. (Institut d'Investigació Biomèdica Sant Pau) ;
Salazar, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Bonfill, X. (Xavier) (Institut d'Investigació Biomèdica Sant Pau)
Esophageal and gastric cancers are a significant public health problem worldwide, with most patients presenting with advanced-stage disease and, consequently, poor prognosis. Systemic oncological treatments (SOT) have been widely used over more conservative approaches, such as supportive care. [...]
2021 - 10.1186/s12885-021-08330-5
BMC Cancer, Vol. 21 (june 2021)
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4.
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18 p, 4.0 MB |
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
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Visnes, T. (Sintef Industry. Department of Biotechnology and Nanomedicine) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Cázares-Körner, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Sanjiv, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Hanna, Bishoy (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Mortusewicz, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rajagopal, Veera M (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Albers, J. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Hagey, D. W. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Bekkhus, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Eshtad, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Masuyer, G. (University of Bath. Department of Pharmacy and Pharmacology) ;
Wallner, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Müller, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Pham, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Göktürk, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rasti, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Suman, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sarno, A. (Sintef Ocean. Department of Environment and New Resources) ;
Wiita, E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Homan, E. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Karsten, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Marimuthu, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Michel, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Koolmeister, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Scobie, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Loseva, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Almlöf, I. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Unterlass, J. E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Pettke, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Boström, J. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Pandey, M. (University of Sheffield. Weston Park Cancer Centre) ;
Gad, H. (University of Sheffield. Weston Park Cancer Centre) ;
Herr, P. (University of Sheffield. Weston Park Cancer Centre) ;
Jemth, A. S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
El Andaloussi, S. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Kalderén, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Krokan, H. E. (Research and Innovation in Central Norway) ;
Altun, M. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Stenmark, P. (Lund University. Department of Experimental Medical Science.) ;
Berglund, U. W. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Helleday, Thomas (University of Sheffield.Weston Park Cancer Centre) ;
Universitat Autònoma de Barcelona
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e. g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. [...]
2021 - 10.1093/nar/gkaa1048
Nucleic acids research, Vol. 48 Núm. 21 (february 2021) , p. 12234-12251
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