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11 p, 912.1 KB |
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing
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Corominas Galbany, Jordi (Radboud University Medical Center) ;
Klein, Marieke (Radboud University Medical Center) ;
Zayats, Tetyana (University of Bergen) ;
Rivero, Olga (University of Würzburg) ;
Ziegler, Georg C. (University of Würzburg) ;
Pauper, Marc (Radboud University Medical Center) ;
Neveling, Kornelia (Radboud University Medical Center) ;
Poelmans, Geert (Radboud University Medical Center) ;
Jansch, Charline (University of Würzburg) ;
Svirin, Evgeniy (I.M. Sechenov First Moscow State Medical University) ;
Geissler, Julia (University Hospital of Würzburg) ;
Weber, Heike (University Hospital of Frankfurt (Alemanya)) ;
Reif, Andreas (University Hospital of Frankfurt (Alemanya)) ;
Arias-Vásquez, Alejandro (Radboud University Medical Center) ;
Galesloot, Tessel E. (Radboud University Medical Center) ;
Kiemeney, Lambertus A. L. M. (Radboud University Medical Center) ;
Buitelaar, Jan (Radboud University Medical Center) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cormand, Bru (Institut de Recerca Sant Joan de Déu) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hveem, Kristian (Norwegian University of Science and Technology) ;
Gabrielsen, Maiken Elvestad (Norwegian University of Science and Technology) ;
Hoffmann, Per (University of Basel) ;
Cichon, Sven (University Hospital Basel (Basilea, Suïssa)) ;
Haavik, Jan (Haukeland University Hospital (Bergen, Noruega)) ;
Johansson, Stefan E (University of Bergen) ;
Jacob, Christian P. (University of Würzburg) ;
Romanos, Marcel (University Hospital of Würzburg) ;
Franke, Barbara (Radboud University Medical Center) ;
Lesch, Klaus-Peter (Maastricht University)
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of underlying genetic risk factors. We hypothesized that combining linkage analysis and whole-exome sequencing (WES) in multi-generation pedigrees with multiple affected individuals can point toward novel ADHD genes. [...]
2018 - 10.1038/s41380-018-0210-6
Molecular psychiatry, Vol. 25 (august 2018) , p. 2047-2057
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10 p, 2.1 MB |
Shared genetic background between children and adults with attention deficit/hyperactivity disorder
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Rovira, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Demontis, Ditte (Center for Genomics and Personalized Medicine, Aarhus, Denmark) ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zayats, Tetyana (Broad Institute of MIT and Harvard) ;
Klein, Marieke (University Medical Center Utrecht) ;
Mota, Nina Roth (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Weber, Heike (University Hospital of Frankfurt (Alemanya)) ;
García-Martinez, Iris (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pagerols, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilar-Ribó, L (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arribas, Lorena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Richarte, Vanesa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Corrales, Montserrat (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fadeuilhe, Christian (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Bosch, Rosa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Martin, Gemma Español (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Almos, Peter (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Doyle, Alysa E. (Harvard Medical School. Department of Psychiatry) ;
Grevet, Eugenio Horacio (Universidade Federal do Rio Grande do Sul. Department of Psychiatry, Faculty of Medicine) ;
Grimm, Oliver (University Hospital of Frankfurt (Alemanya)) ;
Halmøy, Anne (Haukeland University Hospital (Bergen, Noruega)) ;
Hoogman, Martine (Radboud University Medical Center. Department of Human Genetics, Donders Institute for Brain, Cognition, and Behaviour) ;
Hutz, Mara (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Jacob, Christian P. (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Kittel-Schneider, Sarah (University Hospital of Frankfurt (Alemanya)) ;
Knappskog, Per M. (University of Bergen. Department of Clinical Science) ;
Lundervold, Astri J. (University of Bergen. Department of Biological and Medical Psychology) ;
Rivero, Olga (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Rovaris, Diego Luiz (University of São Paulo. Department of Physiology and Biophysics, Institute of Biomedical Sciences) ;
Salatino-Oliveira, Angelica (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
da Silva, Bruna Santos (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Svirin, Evgeniy (IM Sechenov First Moscow State Medical University. Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine) ;
Sprooten, Emma (Radboud University Medical Centre. Department of Cognitive Neuroscience) ;
Strekalova, Tatyana (Maastricht University. Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS)) ;
Arias-Vásquez, Alejandro (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Sonuga-Barke, Edmund J. S. (Aarhus University. Department of Child and Adolescent Psychiatry) ;
Asherson, Philip (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Bau, Claiton Henrique Dotto (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Buitelaar, Jan (Karakter Child and Adolescent Psychiatry, Nijmegen, The Netherlands) ;
Cormand, Bru (Institut de Recerca Sant Joan de Déu) ;
Faraone, Stephen V. (SUNY Upstate Medical University. Departments of Psychiatry, of Neuroscience, and Physiology) ;
Haavik, Jan (Haukeland University Hospital (Bergen, Noruega)) ;
Johansson, Stefan E. (University of Bergen. Department of Clinical Science) ;
Kuntsi, Jonna (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Larsson, Henrik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Lesch, Klaus-Peter (Maastricht University. Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS)) ;
Reif, Andreas (University Hospital of Frankfurt (Alemanya)) ;
Rohde, Luis Augusto (Hospital de Clínicas de Porto Alegre (Brasil)) ;
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Børglum, Anders D. (Center for Genomics and Personalized Medicine, Aarhus, Denmark) ;
Franke, Barbara (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Soler Artigas, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. [...]
2020 - 10.1038/s41386-020-0664-5
Neuropsychopharmacology, Vol. 45 (april 2020) , p. 1617-1626
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7 p, 199.6 KB |
Exome chip analyses in adult attention deficit hyperactivity disorder
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Zayats, Tetyana (University of Bergen. Department of Biomedicine) ;
Jacobsen, K. K. (K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen) ;
Kleppe, R. (K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen) ;
Jacob, Christian P (Section of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition Center of Mental Health, University of Wuerburg) ;
Kittel-Schneider, S. (University Hospital of Frankfurt (Alemanya)) ;
Ribasés, M.. (Centro de Investigación Biomédica en Red de Salud Mental) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Richarte, Vanesa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Mota, N. R. (Department of Genetics, Universidade Federal do Rio Grande do Sul) ;
Grevet, Eugenio Horacio (Department of Psychiatry, Universidade Federal do Rio Grande do Sul) ;
Klein, M. (Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center) ;
Corominas Galbany, Jordi (Department of Ophtalmology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center) ;
Bralten, Janita (Radboud University. Donders Institute for Brain, Cognition and Behaviour) ;
Galesloot, Tessel E (Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center) ;
Vasquez, A. A. (Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center) ;
Herms, Stefan (University of Basel (Suïssa). Department of Biomedicine) ;
Forstner, A. J. (Department of Genomics, Life and Brain Center) ;
Larsson, Henrik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Breen, G. (King's College London. MRC Social Genetic and Developmental Psychiatry Centre) ;
Asherson, Philip (King's College London. MRC Social Genetic and Developmental Psychiatry Centre) ;
Gross-Lesch, S. (Section of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition Center of Mental Health, University of Wuerburg) ;
Lesch, K. P. (Section of Molecular Psychiatry, Clinical Research Unit on Disorders of Neurodevelopment and Cognition Center of Mental Health, University of Wuerburg) ;
Cichon, Sven (Institute of Neuroscience and Medicine, Structural and Functional Organization of the Brain (INM-1), Research Center Juelich) ;
Gabrielsen, M. B. (Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology) ;
Holmen, O. L. (K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology) ;
Bau, Claiton Henrique Dotto (Department of Genetics, Universidade Federal do Rio Grande do Sul) ;
Buitelaar, Jan (Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center) ;
Kiemeney, L. (Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center) ;
Faraone, S. V (Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University) ;
Cormand, Bru (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Franke, Barbara (Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center) ;
Reif, Andreas (University Hospital of Frankfurt (Alemanya)) ;
Haavik, Jan (Haukeland University Hospital (Bergen, Noruega)) ;
Johansson, S.. (Haukeland University Hospital (Bergen, Noruega))
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, is largely unknown. [...]
2016 - 10.1038/tp.2016.196
Translational psychiatry, Vol. 6 (october 2016) , p. e923
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15 p, 2.4 MB |
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
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Brevik, Erlend J. (Universitetet i Bergen) ;
van Donkelaar, Marjolein M. J. (Donders Institute for Brain, Cognition and Behaviour (The Netherlands)) ;
Weber, Heike (Goethe Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) ;
Sánchez Mora, Cristina (Hospital Universitari Vall d'Hebron) ;
Jacob, Christian P (Klinik Nürtingen. Abteilung für Psychiatrie und Psychotherapie) ;
Rivero, Olga (Universität Würzburg. Zentrum fuer Psychische Gesundheit) ;
Kittel-Schneider, Sarah (Universität Würzburg. Zentrum fuer Psychische Gesundheit) ;
García-Martinez, Iris (Hospital Universitari Vall d'Hebron) ;
Aebi, Marcel (Psychiatrische Universitätsklinik Zürich) ;
van Hulzen, Kimm (Donders Institute for Brain, Cognition and Behaviour (The Netherlands)) ;
Cormand, Bru (Universitat de Barcelona. Departament de Genètica) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Lesch, Klaus-Peter (Klinik Nürtingen. Abteilung für Psychiatrie und Psychotherapie) ;
Reif, Andreas (Goethe Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron) ;
Franke, Barbara (Donders Institute for Brain, Cognition and Behaviour (The Netherlands)) ;
Posserud, Maj-Britt (Universitetet i Bergen) ;
Johansson, Stefan E (Haukeland universitetssykehus) ;
Lundervold, Astri J. (Universitetet i Bergen. Senter for nevropsykiatrisk forskning) ;
Haavik, Jan (Universitetet i Bergen) ;
Zayats, Tetyana (Universitetet i Bergen. Senter for nevropsykiatrisk forskning)
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. [...]
2016 - 10.1002/ajmg.b.32434
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 171, issue 5 (July 2016) , p. 733-747
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