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18 p, 591.8 KB |
Cardiac metabolism as a driver and therapeutic target of myocardial infarction
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Zuurbier, Coert J. (University of Amsterdam) ;
Bertrand, Luc (Université catholique de Louvain) ;
Beauloye, Christoph R. (Cliniques Universitaires Saint-Luc) ;
Andreadou, Ioanna (National and Kapodistrian University of Athens) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jespersen, Nichlas R. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Kula-Alwar, Duvaraka (University of Cambridge) ;
Prag, Hiran A. (University of Cambridge) ;
Eric Botker, Hans (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Dambrova, Maija (Latvian Institute of Organic Synthesis) ;
Montessuit, Christophe (University of Geneva School of Medicine) ;
Kaambre, Tuuli (National Institute of Chemical Physics and Biophysics) ;
Liepinsh, Edgars (Latvian Institute of Organic Synthesis) ;
Brookes, Paul S. (University of Rochester Medical Center) ;
Krieg, Thomas (University of Cambridge) ;
Universitat Autònoma de Barcelona
Reducing infarct size during a cardiac ischaemic-reperfusion episode is still of paramount importance, because the extension of myocardial necrosis is an important risk factor for developing heart failure. [...]
2020 -  10.1111/jcmm.15180
Journal of Cellular and Molecular Medicine, Vol. 24 (may 2020) , p. 5937-5954
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12.
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16 p, 2.5 MB |
Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production
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Beltran, Claudia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pardo, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bou-Teen, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villena, Josep A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferreira-Gonzalez, Ignacio (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
After myocardial ischemia-reperfusion, fatty acid oxidation shows fast recovery while glucose oxidation rates remain depressed. A metabolic shift aimed at increasing glucose oxidation has shown to be beneficial in models of myocardial ischemia-reperfusion. [...]
2020 - 10.3390/metabo10040132
Metabolites, Vol. 10 (march 2020)
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13 p, 498.1 KB |
Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST-segment elevation myocardial infarction
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Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Cabrera-Fuentes, H. A. (Kazan (Volga Region) Federal University) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Heusch, Gerd (University of Essen) ;
Ovize, Michel (Université de Lyon)
Pre-clinical studies have indicated that mitoprotective drugs may add cardioprotection beyond rapid revascularization, antiplatelet therapy and risk modification. We review the clinical efficacy of mitoprotective drugs that have progressed to clinical testing comprising cyclosporine A, KAI-9803, MTP131 and TRO 40303. [...]
2020 - 10.1111/jcmm.14953
Journal of Cellular and Molecular Medicine, Vol. 24 (january 2020) , p. 2717-2729
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14.
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11 p, 1.0 MB |
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin
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Blasco, Natividad (Institut de Recerca Biomèdica de Lleida) ;
Cámara, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Núñez, Estefanía (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Beà, Aida (Institut de Recerca Biomèdica de Lleida) ;
Barés, Gisel (Institut de Recerca Biomèdica de Lleida) ;
Forné, Carles (Institut de Recerca Biomèdica de Lleida) ;
Ruíz-Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Girón, Cristina (Institut de Recerca Biomèdica de Lleida) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Arumi, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Martí, Ramon A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llovera, Marta (Institut de Recerca Biomèdica de Lleida) ;
Sanchis, Daniel (Institut de Recerca Biomèdica de Lleida)
The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. [...]
2018 - 10.1016/j.redox.2018.02.021
Redox biology, Vol. 16 (march 2018) , p. 146-156
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13 p, 508.4 KB |
Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia : between bench and bedside
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Cabrera-Fuentes, H. A (Escuela de Ingeniería y Ciencias, Centro de Biotecnología-FEMSA, Tecnológico de Monterrey) ;
Alba-Alba, Corina (Institute of Genetics, Univeristy of the Sea. Puerto Escondido Campus, Oaxaca Oaxacan System of State Universities (SUNEO)) ;
Aragones, Julian (Instituto de Investigación Hospital Universitario de la Princesa) ;
Bernhagen, Jürgen (Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University) ;
Boisvert, William A. (Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Cesarman-Maus, Gabriela (Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico) ;
Fleming, Ingrid (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt, Germany) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lecour, Sandrine (Hatter Institute and MRC Inter-University Cape Heart Unit, Faculty of Health Sciences, University of Cape Town) ;
Liehn, Elisa (Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen) ;
Marber, Michael S. (King's College London) ;
Marina, Nephtali (Department of Clinical Pharmacology, University College London) ;
Mayr, Manuel (King's College London. The James Black Centre) ;
Perez-Mendez, Oscar (Department of Molecular Biology, National Institute of Cardiology, Mexico City) ;
Miura, Tetsuji (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) ;
Ruiz-Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salinas-Estefanon, Eduardo M. (Laboratorio de Biofísica Cardiaca, Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Mexico) ;
Ong, Sang-Bing (National Heart Research Institute Singapore, National Heart Centre Singapore) ;
Schnittler, Hans J. (Institute of Anatomy and Vascular Biology, Westfalian-Wilhelms-University, Münster) ;
Sanchez-Vega, Jose T. (Universidad Nacional Autónoma de México. Departamento de Microbiología y Parasitología) ;
Sumoza-Toledo, Adriana (Laboratorio Multidisciplinario de Ciencias Biomédicas, Instituto de Investigaciones Medico-Biológicas, Universidad Veracruzana campus Veracruz) ;
Vogel, Carl-Wilhelm (Department of Pathology, John A. Burns School of Medicine, University of Hawaii) ;
Yarullina, Dina (Department of Microbiology, Kazan Federal University, Kazan, Russian Federation) ;
Yellon, Derek M. (The National Institute of Health Research University College London Hospitals Biomedical Research Centre) ;
Preissner, Klaus T. (Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany) ;
Hausenloy, Derek J. (The National Institute of Health Research University College London Hospitals Biomedical Research Centre) ;
Universitat Autònoma de Barcelona
Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last "New Frontiers in Cardiovascular Research meeting". Major topics included the characterization of new targets and procedures in cardioprotection, deciphering new players and inflammatory mechanisms in ischemic heart disease as well as uncovering microRNAs and other biomarkers as versatile and possibly causal factors in cardiovascular pathogenesis. [...]
2015 - 10.1007/s00395-015-0527-0
Basic Research in Cardiology, Vol. 111 (december 2015)
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15 p, 2.3 MB |
Defective sarcoplasmic reticulum-mitochondria calcium exchange in aged mouse myocardium
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Fernández Sanz, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Meana, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Miro-Casas, E. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuñez, E. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Castellano, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Loureiro, M. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poncelas, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Sinovas, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Mitochondrial alterations are critically involved in increased vulnerability to disease during aging. We investigated the contribution of mitochondria-sarcoplasmic reticulum (SR) communication in cardiomyocyte functional alterations during aging. [...]
2014 - 10.1038/cddis.2014.526
Cell death and disease, Vol. 5 (december 2014) , p. e1573
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13 p, 340.4 KB |
ESC working group cellular biology of the heart : position paper: improving the preclinical assessment of novel cardioprotective therapies
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Lecour, Sandrine (Hatter Institute for Cardiovascular Research (Àfrica)) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Condorelli, Gianluigi (Instituto Clinico Humanitas (Milano, Itàlia)) ;
Davidson, Sean M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
García-Dorado, David (Universitat Autònoma de Barcelona) ;
Engel, Felix B. (Friedrich-Alexander-Universität Erlangen-Nürnberg) ;
Ferdinandy, Péter (Semmelweis Egyetem. Department of Pharmacology and Pharmacotherapy) ;
Heusch, Gerd (Universitätsklinikum Essen) ;
Madonna, Rosalinda (Università degli Studi "G. d'Annunzio" Chieti) ;
Ovize, Michel (Université Claude Bernard Lyon 1) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Schulz, Rainer (Justus Liebig-Universität Gießen) ;
Sluijter, Joost P. G. (Universitair Medisch Centrum Utrecht) ;
Van Laake, Linda W. (Universitair Medisch Centrum Utrecht) ;
Yellon, Derek M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
Hausenloy, Derek J. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit))
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. [...]
2014 - 10.1093/cvr/cvu225
Cardiovascular research, Vol. 104, issue 3 (Dec. 2014) , p. 399-411
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63 p, 148.5 KB |
Mecanismo del daño mecánico letal por reoxigenación en miocitos cardíacos
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Ruiz Meana, Marisol ;
García Dorado, D., dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Los miocitos cardíacos sometidos a hipoxia prolongada presentan un gran aumento en la concentración de Ca2+ citosólico. Durante la reoxigenación, la reactivación de la producción energética mitocondrial en presencia de Ca2+ citosólico elevado provoca una activación exagerada de la contractilidad celular que puede llegar a deformar irreversiblemente el citoesqueleto y romper la membrana celular. [...]
Prolonged hypoxia induces cytosolic Ca2+ overload in cardiac myocytes. During reoxygenation, reactivation of mitochondrial ATP production in the presence of high cytosolic Ca2+ levels induces an exaggerated contractile activity that eventually leads to irreversible cytoskeleton as well as sarcolemmal disruption. [...]
Bellaterra : Universitat Autònoma de Barcelona, 2005
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