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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 -  10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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15 p, 8.8 MB |
Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators
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Garcia, Sergio G. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sandoval-Hellín, Noelia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos Sansalvador, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carreras-Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Regulatory B cells (Breg) are essential players in tolerance and immune homeostasis. However, lack of specific Breg markers limit their potential in clinical settings. Mesenchymal stromal cells (MSC) modulate B cell responses and are described to induce Breg in vitro. [...]
2022 - 10.3389/fimmu.2022.957797
Frontiers in immunology, Vol. 13 (september 2022)
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16 p, 1.9 MB |
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia : An In Silico Approach
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Lozano, Maria L. (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Segú-Vergés, Cristina (Anaxomics Biotech SL) ;
Coma, Mireia (Anaxomics Biotech SL) ;
Alvarez-Román, María Teresa (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
González-Porras, José Ramón (Hospital Universitario de Salamanca) ;
Gutiérrez, Laura (Universidad de Oviedo) ;
Valcárcel, David (Vall d'Hebron Institut d'Oncologia) ;
Butta, Nora (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Eltrombopag is a thrombopoietin receptor (MPL) agonist approved for the treatment of primary immune thrombocytopenia (ITP). Recent evidence shows that some patients may sustain platelet counts following eltrombopag discontinuation. [...]
2021 - 10.3390/ijms22136907
International journal of molecular sciences, Vol. 22 (june 2021)
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5.
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13 p, 1.5 MB |
Evaluation of an O 2-Substituted (1-3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn's Disease
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Notararigo, Sara (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Varela, Encarnación (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Otal, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cristobo, Iván (Centro de Investigaciones Biológicas (Madrid)) ;
Antolín, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Prieto, Alicia (Centro de Investigaciones Biológicas (Madrid)) ;
López, Paloma (Centro de Investigaciones Biológicas (Madrid)) ;
Universitat Autònoma de Barcelona
1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Among them, the O 2-substituted-(1-3)-β-D-glucan, synthesized by some lactic acid bacteria (LAB), has a prebiotic effect on probiotic strains, an immunomodulatory effect on monocyte-derived macrophages, and potentiates the ability of the producer strain to adhere to Caco-2 cells differentiated to enterocytes. [...]
2021 - 10.3389/fmicb.2021.621280
Frontiers in microbiology, Vol. 12 (february 2021)
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6.
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14 p, 3.8 MB |
dIvergEnt : How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies
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Palomares, Óscar (Universidad Complutense de Madrid) ;
Sánchez-Ramón, Silvia (Universidad Complutense de Madrid. Departamento de Microbiología y Parasitología) ;
Dávila, Ignacio (Instituto de Investigación Biomédica de Salamanca) ;
Prieto, Luis (Hospital Universitari Doctor Peset (València)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Lleonart, Marta (Novartis Farmacéutica (Espanya)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Nieto Garcíá, Antonio (Hospital Universitari i Politècnic La Fe (València)) ;
Universitat Autònoma de Barcelona
Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. [...]
2017 - 10.3390/ijms18061328
International journal of molecular sciences, Vol. 18 (june 2017)
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7.
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17 p, 5.8 MB |
Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis
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Barrachina, Laura (Universidad de Zaragoza. Servicio de Cirugía y Medicina Equina) ;
Remacha, Ana Rosa (Universidad de Zaragoza. Instituto Agroalimentario de Aragón) ;
Romero, Antonio (Universidad de Zaragoza. Servicio de Cirugía y Medicina Equina) ;
Vitoria, Arantza (Universidad de Zaragoza. Servicio de Cirugía y Medicina Equina) ;
Albareda, Jorge (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Prades, Marta (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Roca, Mercedes (Clínica Doctora Roca Diagnóstico Médico) ;
Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón) ;
Vázquez, Francisco José (Universidad de Zaragoza. Servicio de Cirugía y Medicina Equina) ;
Rodellar, Clementina (Universidad de Zaragoza. Instituto Agroalimentario de Aragón)
This study aimed at assessing the effectiveness and safety of repeated administrations of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) primed with tumor necrosis factor (TNF)-α and interferon-γ in an equine model of chemically-induced osteoarthritis. [...]
2018 - 10.1186/s12917-018-1556-3
BMC veterinary research, Vol. 14 (august 2018)
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21 p, 1020.6 KB |
Potential of Extracellular Vesicle-Associated TSG-6 from Adipose Mesenchymal Stromal Cells in Traumatic Brain Injury
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Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos Sansalvador, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Multipotent mesenchymal stromal cells (MSC) represent a promising strategy for a variety of medical applications. Although only a limited number of MSC engraft and survive after in vivo cellular infusion, MSC have shown beneficial effects on immunomodulation and tissue repair. [...]
2020 - 10.3390/ijms21186761
International journal of molecular sciences, Vol. 21 (september 2020)
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229 p, 28.0 MB |
Desarrollo de nuevas estrategias de terapia génica como tratamiento inmunomodulador de la esclerosis múltiple
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Edo Salvador, Ángel ;
Chillón Rodríguez, Miguel, dir. ;
Espejo, Carmen, dir.
L'esclerosis múltiple és una malaltia desmielinitzant d'etologia desconeguda, tanmateix, és conegut que el sistema immunitari és el causant dels atacs infamatoris contra la mielina dels axons neuronals. [...]
La esclerosis múltiple es una enfermedad desmielinizante de etiología desconocida, sin embargo, está ampliamente estudiado que el sistema inmunitario es el causante de los ataques inflamatorios contra la mielina de los axones neuronales. [...]
Multiple sclerosis is a demyelinating disease of unknown etiology, however, it has been widely studied that the immune system is the cause of the inflammatory attacks against myelin in the neuronal axons. [...]
2020
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