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234.
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235.
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236.
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12 p, 3.6 MB |
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
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Jung, H. (Department of Bio and Brain Engineering. KAIST) ;
Kim, H. S. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ;
Kim, J. Y. (Department of Bio and Brain Engineering. KAIST) ;
Sun, J. M. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ;
Ahn, Jin Seop (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ;
Ahn, M. J. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ;
Park, K. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lee, S. H. (Department of Health Sciences and Technology. Samsung Advanced Institute of Health Science and Technology. Sungkyunkwan University) ;
Choi, J. K. (Penta Medix Co.. Ltd.) ;
Universitat Autònoma de Barcelona
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. [...]
2019 -  10.1038/s41467-019-12159-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4278
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237.
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18 p, 2.5 MB |
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition
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Oliveira-Mateos, Cristina (Institut d'Investigació Biomèdica de Bellvitge) ;
Sánchez-Castillo, Anaís (Centro de Investigación Biomédica en Red de Cáncer) ;
Soler, Marta (Institut d'Investigació Biomèdica de Bellvitge) ;
Obiols-Guardia, Aida (Institut d'Investigació Biomèdica de Bellvitge) ;
Piñeyro, David (Institut d'Investigació Biomèdica de Bellvitge) ;
Boque-Sastre, Raquel (Cardiff School of Biosciences. Cardiff University) ;
Calleja-Cervantes, María Eréndira (Institut d'Investigació Biomèdica de Bellvitge) ;
Castro de Moura, Manuel (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez Cardús, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Rubio Lopez, Maria Teresa (Institut d'Investigació Biomèdica de Bellvitge) ;
Pelletier, Joffrey (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez-Iniesta, Maria (Institut d'Investigació Biomèdica de Bellvitge) ;
Herrero-Martín, David (Institut d'Investigació Biomèdica de Bellvitge) ;
Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gentilella, Antonio (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Farré, Lourdes (Fundação Oswaldo Cruz (Brasil)) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseudogene RPSAP52. [...]
2019 - 10.1038/s41467-019-11910-6
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3979
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238.
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11 p, 3.4 MB |
Identification of key sequence features required for microRNA biogenesis in plants
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Rojas, Arantxa M. L. (Instituto de Biología Molecular y Celular de Rosario) ;
Drusin, Salvador I. (Instituto de Biología Molecular y Celular de Rosario) ;
Chorostecki, Uciel Pablo (Institut de Recerca Biomèdica) ;
Mateos, Julieta Lisa (Instituto de Fisiología, Biología Molecular y Neurociencias) ;
Moro, Belen (Centre de Recerca en Agrigenòmica) ;
Bologna, Nicolás (Centre de Recerca en Agrigenòmica) ;
Bresso, Edgardo G. (Instituto de Biología Molecular y Celular de Rosario) ;
Schapire, Arnaldo (Instituto de Biología Molecular y Celular de Rosario) ;
Rasia, Rodolfo (Instituto de Biología Molecular y Celular de Rosario) ;
Moreno, Diego M. (Universidad Nacional de Rosario. Departamento de Química-Física) ;
Palatnik, Javier (Instituto de Biología Molecular y Celular de Rosario)
MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. [...]
2020 - 10.1038/s41467-020-19129-6
Nature communications, Vol. 11 (October 2020) , art. 5320
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239.
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15 p, 4.1 MB |
Donkey genomes provide new insights into domestication and selection for coat color
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Wang, Changfa (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Li, Haijing (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Guo, Yu (BGI-Shenzhen) ;
Huang, Jinming (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Sun, Yan (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Min, Jiumeng (BGI-Shenzhen) ;
Wang, Jinpeng (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Fang, Xiaodong (BGI-Shenzhen) ;
Zhao, Zicheng (City University of Hong Kong. Department of Computer Science) ;
Wang, Shuai (City University of Hong Kong. Department of Computer Science) ;
Zhang, Yanlin (City University of Hong Kong. Department of Computer Science) ;
Liu, Qingfeng (BGI-Shenzhen) ;
Jiang, Qiang (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Wang, Xiuge (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Guo, Yijun (BGI-Shenzhen) ;
Yang, Chunhong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Wang, Yinchao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Tian, Fang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Zhuang, Guilong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Fan, Yanna (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Gao, Qican (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Yuhua (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Ju, Zhihua (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Jianbin (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Rongling (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Hou, Minghai (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Yang, Guiwen (Shandong Normal University. College of Life Science) ;
Liu, Guiqin (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Liu, Wenqiang (Liaocheng University Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding.) ;
Guo, Jiao (BGI-Shenzhen) ;
Pan, Shanshan (BGI-Shenzhen) ;
Fan, Guangyi (BGI-Shenzhen) ;
Zhang, Wei (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Zhang, Ruitao (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Yu, Jie (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Zhang, Xinhao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Yin, Qi (BGI-Shenzhen) ;
Ji, Chuanliang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Jin, Yuanchun (BGI-Shenzhen) ;
Yue, Guidong (BGI-Shenzhen) ;
Liu, Mei (Nanjing Normal University. Jiangsu Key Laboratory for Molecular and Medical Biotechnology) ;
Xu, Jiake (The University of Western Australia . School of Biomedical Sciences) ;
Liu, Shimin (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Noce, Antonia (Centre de Recerca en Agrigenòmica) ;
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica) ;
Wu, Dong-Dong (Chinese Academy of Sciences. Center for Excellence in Animal Evolution and Genetics) ;
Li, Shuaicheng (City University of Hong Kong. Department of Computer Science) ;
Zhou, Xiangshan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ;
Zhong, Jifeng (Jiangsu Academy of Agricultural Sciences. Institute of Animal Science)
Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. [...]
2020 - 10.1038/s41467-020-19813-7
Nature communications, Vol. 11 (December 2020) , art. 6014
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240.
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15 p, 2.9 MB |
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer
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Mattesen, T. B. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Rasmussen, M. H. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Sandoval, J. (Instituto de Investigación Sanitaria La Fe) ;
Ongen, H. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ;
Árnadóttir, S. S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Gladov, J. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Madsen, A. H. (Department of Surgery. Hospitalsenheden Vest) ;
Laurberg, S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Dermitzakis, Emmanouil T (University of Geneva Medical School) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Universitat Autònoma de Barcelona
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. [...]
2020 - 10.1038/s41467-020-16000-6
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2025
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241.
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14 p, 1.8 MB |
In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells
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Martinez-Lage , Marta (Centro Nacional de Investigaciones Oncológicas) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Puig-Serra, Pilar (Centro Nacional de Investigaciones Oncológicas) ;
Moreno-Gaona, Patricia (Centro Nacional de Investigaciones Oncológicas) ;
Martin, M. Carmen (Centro Nacional de Investigaciones Oncológicas) ;
Moya, Francisco J. (Centro Nacional de Investigaciones Oncológicas) ;
Quintana-Bustamante, Oscar (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Garcia-Silva, Susana (Centro Nacional de Investigaciones Oncológicas) ;
Carcaboso, Angel M (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Peinado, Héctor (Centro Nacional de Investigaciones Oncológicas) ;
Segovia, Jose C. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of tumor development. Because their expression is exclusive to cancer cells and their elimination induces cell apoptosis in FO-driven cancers, FOs are attractive therapeutic targets. [...]
2020 - 10.1038/s41467-020-18875-x
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 5060
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242.
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17 p, 5.7 MB |
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
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Colli, M. L. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Ramos-Rodríguez, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nakayasu, E. S. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Alvelos, M. I. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Lopes, M. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Hill, J. L. E. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Turatsinze, J. V. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Coomans de Brachène, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Russell, M. A. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Raurell Vila, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castela, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Juan-Mateu, J. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Webb-Robertson, B. J. M. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Krogvold, L. (Oslo University Hospital (Oslo, Noruega)) ;
Dahl-Jorgensen, K. (Oslo University Hospital (Oslo, Noruega)) ;
Marselli, L. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Marchetti, P. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Richardson, S. J. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Morgan, N. G. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Metz, T. O. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eizirik, D. L. (Indiana Biosciences Research Institute) ;
Universitat Autònoma de Barcelona
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. [...]
2020 - 10.1038/s41467-020-16327-0
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2584
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243.
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32 p, 2.7 MB |
Ultralow-dielectric-constant amorphous boron nitride
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Hong, Seokmo (Ulsan National Institute of Science and Technology. Department of Chemistry) ;
Lee, Chang-Seok (Samsung Advanced Institute of Technology. Inorganic Material Lab.) ;
Lee, Min-Hyun (Samsung Advanced Institute of Technology. Inorganic Material Lab.) ;
Lee, Yeongdong (Ulsan National Institute of Science and Technology. School of Materials Science and Engineering) ;
Ma, Kyung Yeol (Ulsan National Institute of Science and Technology. Department of Energy Engineering) ;
Kim, Gwangwoo (Ulsan National Institute of Science and Technology. Department of Chemistry) ;
Yoon, Seong In (Ulsan National Institute of Science and Technology. Department of Energy Engineering) ;
Ihm, Kyuwook Ihm (Pohang Accelerator Laboratory) ;
Kim, Ki-Jeong (Pohang Accelerator Laboratory) ;
Shin, Tae Joo (Ulsan National Institute of Science and Technology. Department of Chemistry) ;
Kim, Sang Won (Samsung Advanced Institute of Technology. Inorganic Material Lab.) ;
Jeon, Eun-chae (University of Ulsan. School of Materials Science and Engineering) ;
Jeon, Hansol (Ulsan National Institute of Science and Technology. School of Materials Science and Engineering) ;
Kim, Ju-Young (Ulsan National Institute of Science and TechnologY. School of Materials Science and Engineering) ;
Lee, Hyung-Ik (Samsung Advanced Institute of Technology. Analytical Engineering Group) ;
Lee, Zonghoon (Center for Multidimensional Carbon Materials (Ulsan, Corea del Nord)) ;
Antidormi, Aleandro (Institut Català de Nanociència i Nanotecnologia) ;
Roche, Stephan (Institut Català de Nanociència i Nanotecnologia) ;
Chhowalla, Manish (University of Cambridge. Department of Materials Science & Metallurgy) ;
Shin, Hyeon-Jin (Samsung Advanced Institute of Technology. Inorganic Material Lab.) ;
Shin, Hyeon Suk (Ulsan National Institute of Science and Technology. Low-Dimensional Carbon Materials Center)
Decrease in processing speed due to increased resistance and capacitance delay is a major obstacle for the down-scaling of electronics. Minimizing the dimensions of interconnects (metal wires that connect different electronic components on a chip) is crucial for the miniaturization of devices. [...]
2020 - 10.1038/s41586-020-2375-9
Nature, Vol. 582, issue 7813 (June 2020) , p. 511-514
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