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812.9 KB |
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
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Moon, Katherine L. (University of California. Department of Ecology and Evolutionary Biology) ;
Huson, Heather J. (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ;
Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Wang, Ming-Shan (University of California. Howard Hughes Medical Institute) ;
Li, Xue (Broad Institute of MIT and Harvard) ;
Srikanth, Krishnamoorthy (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ;
Svenson, Gavin J. (Cleveland Museum of Natural History) ;
Karlsson, Elinor K. (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ;
Shapiro, Beth (University of California. Department of Ecology and Evolutionary Biology)
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. [...]
2023 -  10.1126/science.abn5887
Science, Vol. 380 Num. 6643 (April 2023) , art. eabn5887
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15 p, 2.7 MB |
Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe : The use of statistical simulation to evaluate methods for the rapid assessment of potential safety issues on a population level in the SOMNIA study
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Dodd, Caitlin N. (Erasmus Medical Center (Rotterdam)) ;
de Ridder, Maria A. J. (Erasmus Medical Center (Rotterdam)) ;
Huang, Wan-Ting (Taiwan Centers for Disease Control) ;
Weibel, Daniel (Erasmus Medical Center (Rotterdam)) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona) ;
Perez-Vilar, Silvia (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (València)) ;
Diez-Domingo, Javier (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (València)) ;
Svenson, Lawrence W. (University of Alberta) ;
Mahmud, Salaheddin M (University of Manitoba) ;
Carleton, Bruce (University of British Columbia) ;
Naus, Monika (University of British Columbia) ;
Kwong, Jeffrey C. (University Health Network (Toronto)) ;
Murray, Brian J. (Sunnybrook Health Sciences Centre (Toronto)) ;
Arnheim-Dahlström, Lisen (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Pedersen, Lars (Aarhus University. Department of Clinical Epidemiology) ;
Morros, Rosa (Universitat Autònoma de Barcelona) ;
Puertas, Francisco Javier (University of Valencia. Physiology Department) ;
Black, Steven (Cincinnati Children's Hospital Medical Center) ;
Sturkenboom, Miriam (University Medical Center Utrecht. Julius Center Global Health)
Vaccine safety signals require investigation, which may be done rapidly at the population level using ecological studies, before embarking on hypothesis-testing studies. Incidence rates were used to assess a signal of narcolepsy following AS03-adjuvanted monovalent pandemic H1N1 (pH1N1) influenza vaccination among children and adolescents in Sweden and Finland in 2010. [...]
2018 - 10.1371/journal.pone.0204799
PloS one, Vol. 13 Núm. 10 (october 2018)
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16 p, 2.3 MB |
Identification of genetic elements in metabolism by high-throughput mouse phenotyping
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Rozman, Jan (German Center for Diabetes Research) ;
Rathkolb, Birgit (Ludwig Maximilians Universität München. Institute of Molecular Animal Breeding and Biotechnology) ;
Oestereicher, Manuela A. (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Schütt, Christine (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Ravindranath, Aakash Chavan (Helmholtz Zentrum München. Institute of Bioinformatics and Systems Biology) ;
Leuchtenberger, Stefanie (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Sharma, Sapna (Helmholtz Zentrum München. Institute of Epidemiology II) ;
Kistler, Martin (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Willershäuser, Monja (Technical University of Munich. Institute for Food and Health) ;
Brommage, Robert (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Meehan, Terrence F. (European Bioinformatics Institute) ;
Mason, Jeremy (European Bioinformatics Institute) ;
Haselimashhadi, Hamed (European Bioinformatics Institute) ;
Hough, Tertius (Medical Research Council Harwell) ;
Mallon, Ann-Marie (Medical Research Council Harwell) ;
Wells, Sara (Medical Research Council Harwell) ;
Santos, Luis (Medical Research Council Harwell) ;
Lelliott, Christopher J. (Wellcome Trust Sanger Institute (Regne Unit)) ;
White, Jacqueline K. (The Jackson Laboratory) ;
Sorg, Tania (Université de Strasbourg) ;
Champy, Marie-France (Université de Strasbourg) ;
Bower, Lynette R. (University of California. Mouse Biology Program) ;
Reynolds, Corey L. (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Flenniken, Ann M. (Mount Sinai Hospital) ;
Murray, Stephen A. (The Jackson Laboratory) ;
Nutter, Lauryl M. J. (The Hospital for Sick Children) ;
Svenson, Karen L. (The Jackson Laboratory) ;
West, David (Children's Hospital Oakland Research Institute) ;
Tocchini-Valentini, Glauco P. (Monterotondo Mouse Clinic. Institute of Cell Biology and Neurobiology) ;
Beaudet, Arthur L. (The Hospital for Sick Children) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Braun, Robert B. (The Jackson Laboratory) ;
Dobbie, Michael S. (Australian National University) ;
Gao, Xiang (Nanjing University. Collaborative Innovation Center for Genetics and Development) ;
Herault, Yann (Université de Strasbourg) ;
Moshiri, Ala (School of Medicine U.C. Davis. Department of Ophthalmology and Vision Science) ;
Moore, Bret A. (School of Veterinary Medicine U.C. Davis) ;
Lloyd, Kent (University of California) ;
McKerlie, Colin (The Hospital for Sick Children) ;
Masuya, Hiroshi (RIKEN BioResource Center) ;
Tanaka, Nobuhiko (RIKEN BioResource Center) ;
Flicek, Paul (European Bioinformatics Institute) ;
Parkinson, Helen E. (European Bioinformatics Institute) ;
Sedlacek, Radislav (Institute of Molecular Genetics. Czech Centre for Phenogenomics) ;
Seong, Je Kyung (Seoul National University. College of Veterinary Medicine) ;
Wang, Chi-Kuang Leo (National Laboratory Animal Center) ;
Moore, Mark (International Mouse Phenotyping Consortium) ;
Brown, Steve D. M (Medical Research Council Harwell) ;
Tschöp, Matthias H. (Technische Universität München. Department of Medicine) ;
Wurst, Wolfgang (Ludwig Maximilians Universität München. Adolf Butenandt Institut) ;
Klingenspor, Martin (Technical University of Munich. Institute for Food & Health) ;
Wolf, Eckhard (Ludwig Maximilians Universität München. Institute of Molecular Animal Breeding and Biotechnology) ;
Beckers, Johannes (Technische Universität München. School of Life Science Weihenstephan) ;
Machicao, Fausto (University of Tübingen. Department of Internal Medicine) ;
Peter, Andreas (Eberhard Karls University of Tuebingen. Institute for Diabetes Research and Metabolic Diseases) ;
Staiger, Harald (Eberhard Karls University Tübingen. Department of Pharmacy and Biochemistry) ;
Häring, Hans-Ulrich (Eberhard Karls University of Tuebingen. Institute for Diabetes Research and Metabolic Diseases) ;
Grallert, Harald (Ludwig-Maximilians-Universität München) ;
Campillos, Monica (Helmholtz Zentrum München. Institute of Bioinformatics and Systems Biology) ;
Maier, Holger (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Fuchs, Helmut (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Gailus-Durner, Valerie (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Werner, Thomas (University of Michigan. Internal Medicine Nephrology and Center for Computational Medicine and Bioinformatics) ;
De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan)
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. [...]
2018 - 10.1038/s41467-017-01995-2
Nature communications, Vol. 9 (January 2018) , art. 288
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22 p, 620.6 KB |
Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment
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Weibel, Daniel (Erasmus Medical Center (Rotterdam, Països Baixos)) ;
Sturkenboom, Miriam (University Utrecht Medical Center) ;
Black, Steven (Cincinnati Children's Hospital Medical Center) ;
de Ridder, Maria A. J. (Erasmus Medical Center (Rotterdam, Països Baixos)) ;
Dodd, Caitlin (Erasmus Medical Center (Rotterdam, Països Baixos)) ;
Bonhoeffer, Jan (Brighton Collaboration Foundation (Basilea, Suïssa)) ;
Vanrolleghem, Ann (Erasmus Medical Center (Rotterdam, Països Baixos)) ;
van der Maas, Nicoline (National Institute for Public Health and the Environment (Bilthoven, Països Baixos)) ;
Lammers, Gert Jan (Sleep-Wake Center SEIN (Heemstede, Països Baixos)) ;
Overeem, Sebastiaan (Sleep Medicine Centre Kempenhaeghe (Heeze, Països Baixos)) ;
Gentile, Angela (Hospital de Niños Ricardo Gutiérrez (Buenos Aires, Argentina)) ;
Giglio, Norberto (Hospital de Niños Ricardo Gutiérrez (Buenos Aires, Argentina)) ;
Castellano, Vanesa (Hospital de Niños Ricardo Gutiérrez (Buenos Aires, Argentina)) ;
Kwong, Jeffrey C. (Institute for Clinical Evaluative Sciences-ICES (Ontario, Canada)) ;
Murray, Brian J. (University of Toronto) ;
Cauch-Dudek, Karen (Institute for Clinical Evaluative Sciences-ICES (Ontario, Canada)) ;
Juhasz, Diana (Institute for Clinical Evaluative Sciences-ICES (Ontario, Canada)) ;
Campitelli, Michael (Institute for Clinical Evaluative Sciences-ICES (Ontario, Canada)) ;
Datta, Alexandre N. (University Hospital Basel (Basilea, Suïssa)) ;
Kallweit, Ulf (Witten/Herdecke University) ;
Huang, Wan-Ting (Taiwan Centers for Disease Control) ;
Huang, Yu-Shu (Chang Gung Memorial Hospital (Taiwan). Department of Child Psychiatry and Sleep Center) ;
Hsu, Chung-Yao (Kaohsiung Medical University Hospital (Kaohsiung, Taiwan)) ;
Chen, Hsi-Chung (National Taiwan University Hospital (Taipei, Taiwan)) ;
Giner-Soriano, Maria (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Gaig, Carles (Hospital Clínic i Provincial de Barcelona) ;
Tió, Ester (Althaia Xarxa Assistencial Universitària de Manresa (Manresa, Catalunya)) ;
Perez-Vilar, Silvia (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat -FISABIO (València)) ;
Diez-Domingo, Javier (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (València)) ;
Puertas, Francisco Javier (Hospital Universitari de la Ribera (València)) ;
Svenson, Lawrence W. (University of Alberta (Alberta, Canada). Division of Preventive Medicine) ;
Mahmud, Salaheddin M. (University of Manitoba (Manitoba, Canada). Rady Faculty of Health Sciences) ;
Carleton, Bruce (University of British Columbia. Faculty of Medicine) ;
Naus, Monika (University of British Columbia. Faculty of Medicine) ;
Arnheim-Dahlström, Lisen (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Pedersen, Lars (Aarhus University (Aarhus, Dinamarca)) ;
DeStefano, Frank (Centers for Disease Control and Prevention-CDC (Atlanta, Estats Units d'Amèrica)) ;
Shimabukuro, Tom T. (Centers for Disease Control and Prevention-CDC (Atlanta, Estats Units d'Amèrica)) ;
Universitat Autònoma de Barcelona
In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess a possible association and inform policy on future use of adjuvants, we conducted a multi-country study of narcolepsy and adjuvanted pH1N1 vaccines. [...]
2018 - 10.1016/j.vaccine.2018.08.008
Vaccine, Vol. 36 (august 2018) , p. 6202-6211
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15 p, 1.0 MB |
R2d2 drives selfish sweeps in the house mouse
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Didion, John P. (Carolina Center for Genome Science) ;
Morgan, Andrew P. (Carolina Center for Genome Science) ;
Yadgary, Liran (Carolina Center for Genome Science) ;
Bell, Timothy A. (Carolina Center for Genome Science) ;
McMullan, Rachel C. (Carolina Center for Genome Science) ;
Ortiz de Solorzano, Lydia (Carolina Center for Genome Science) ;
Britton-Davidian, Janice (Université de Montpellier. Institut des Sciences de l'Evolution) ;
Bult, Carol J. (The Jackson Laboratory) ;
Campbell, Karl J. (The University of Queensland. School of Geography, Planning & Environmental Management) ;
Castiglia, Riccardo (Università degli studi di Roma "La Sapienza") ;
Ching, Yung-Hao (Tzu Chi University. Department of Molecular Biology and Human Genetics) ;
Chunco, Amanda J. (Elon University. Department of Environmental Studies) ;
Crowley, James J. (The University of North Carolina at Chapel Hill. Department of Genetics) ;
Chesler, Elissa J. (The Jackson Laboratory) ;
Förster, Daniel W. (Leibniz-Institut für Zoo- und Wildtierforschung. Department of Evolutionary Genetics) ;
French, John E. (National Institute of Environmental Health Sciences. National Toxicology Program) ;
Gabriel, Sofia I. (Universidade de Lisboa. Department of Animal Biology) ;
Gatti, Daniel M. (The Jackson Laboratory) ;
Garland, Theodore (University of California, Riverside. Department of Biology) ;
Giagia-Athanasopoulou, Eva B. (University of Patras. Department of Biology) ;
Giménez, Mabel D. (Universidad Nacional de Misiones (Argentina). Instituto de Biología Subtropical) ;
Grize, Sofia A. (Universität Zürich. Institute of Evolutionary Biology and Environmental Studies) ;
Gündüz, İslam (University of Ondokuz Mayis. Department of Biology, Faculty of Arts and Sciences) ;
Holmes, Andrew (National Institutes of Health. National Institute on Alcohol Abuse and Alcoholism) ;
Hauffe, Heidi C. (Fondazione Edmund Mach. Department of Biodiversity and Molecular Ecology, Research and Innovation Centre) ;
Herman, Jeremy S. (National Museums Scotland. Department of Natural Sciences) ;
Holt, James M. (The University of North Carolina at Chapel Hill. Department of Computer Science) ;
Hua, Kunjie (The University of North Carolina at Chapel Hill. Department of Genetics) ;
Jolley, Wesley J. (Island Conservation (Santa Cruz, Califòrnia)) ;
Lindholm, Anna K. (Universität Zürich. Institute of Evolutionary Biology and Environmental Studies) ;
López-Fuster, María J. (Universitat de Barcelona. Facultat de Biologia) ;
Mitsainas, George (University of Patras. Department of Biology) ;
da Luz Mathias, Maria (Universidade de Lisboa. Department of Animal Biology) ;
McMillan, Leonard (The University of North Carolina at Chapel Hill. Department of Computer Science) ;
Ramalhinho, Maria da Graça Morgado (Universidade de Lisboa. Department of Animal Biology) ;
Rehermann, Barbara (National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, Estats Units d'Amèrica)) ;
Rosshart, Stephan P. (National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, Estats Units d'Amèrica)) ;
Searle, Jeremy B. (Cornell University. Department of Ecology and Evolutionary Biology) ;
Shiao, Meng-Shin (Mahidol University. Faculty of Medicine) ;
Solano, Emanuela (Università degli studi di Roma "La Sapienza") ;
Svenson, Karen L. (The Jackson Laboratory) ;
Thomas-Laemont, Patricia (Elon University. Department of Environmental Studies) ;
Threadgill, David W. (Texas A&M University. Department of Molecular and Cellular Medicine) ;
Ventura Queija, Jacinto (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Weinstock, George M. (Jackson Laboratory for Genomic Medicine) ;
Pomp, Daniel (Carolina Center for Genome Science) ;
Churchill, Gary A. (The Jackson Laboratory) ;
Pardo-Manuel de Villena, Fernando (Carolina Center for Genome Science)
A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. [...]
2016 - 10.1093/molbev/msw036
Molecular biology and evolution, Vol. 33, issue 6 (June 2016) , p. 1381-1395
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