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19 p, 13.4 MB Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis : evidence for metformin-based "starvation" strategies in BRCA1 carriers / Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ; Fernández-Arroyo, Salvador (Hospital Universitari Sant Joan de Reus (Tarragona)) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Joven, Jorge (Hospital Universitari Sant Joan de Reus (Tarragona)) ; Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona)
We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. [...]
2016 - 10.18632/oncotarget.9732
Oncotarget, Vol. 7 (may 2016) , p. 52974-52992  
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