On the use of Parylene C polymer as substrate for peripheral nerve electrodes
de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mueller, Matthias (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK)
Stieglitz, Thomas (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK)
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)

Date:	2018
Abstract:	Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. We evaluated 1-year-aged in vitro samples, where no chemical differences were observed and only a slight deviation on Young's modulus was found. The foreign body reaction (FBR) to longitudinal Parylene C devices implanted in the rat sciatic nerve for 8 months was characterized. After 2 weeks, a capsule was formed around the device, which continued increasing up to 16 and 32 weeks. Histological analyses revealed two cell types implicated in the FBR: macrophages, in contact with the device, and fibroblasts, localized in the outermost zone after 8 weeks. Molecular analysis of implanted nerves comparing Parylene C and polyimide devices revealed a peak of inflammatory cytokines after 1 day of implant, returning to low levels thereafter. Only an increase of CCL2 and CCL3 was found at chronic time-points for both materials. Although no molecular differences in the FBR to both polymers were found, the thick tissue capsule formed around Parylene C puts some concern on its use as a scaffold for intraneural electrodes.
Grants:	European Commission 611687 Instituto de Salud Carlos III RD12-0019-0011 Instituto de Salud Carlos III CB06-05-1105 Ministerio de Economía y Competitividad SEV-2013-0295
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomedical materials ; Inflammation ; Peripheral nervous system
Published in:	Scientific reports, Vol. 8 (April 2018) , art. 5965, ISSN 2045-2322

DOI: 10.1038/s41598-018-24502-z
PMID: 29654317

12 p, 2.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles