Web of Science: 26 cites, Scopus: 33 cites, Google Scholar: cites,
On the use of Parylene C polymer as substrate for peripheral nerve electrodes
de la Oliva, Natàlia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mueller, Matthias (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK)
Stieglitz, Thomas (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK)
Navarro, Xavier (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)

Data: 2018
Resum: Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. We evaluated 1-year-aged in vitro samples, where no chemical differences were observed and only a slight deviation on Young's modulus was found. The foreign body reaction (FBR) to longitudinal Parylene C devices implanted in the rat sciatic nerve for 8 months was characterized. After 2 weeks, a capsule was formed around the device, which continued increasing up to 16 and 32 weeks. Histological analyses revealed two cell types implicated in the FBR: macrophages, in contact with the device, and fibroblasts, localized in the outermost zone after 8 weeks. Molecular analysis of implanted nerves comparing Parylene C and polyimide devices revealed a peak of inflammatory cytokines after 1 day of implant, returning to low levels thereafter. Only an increase of CCL2 and CCL3 was found at chronic time-points for both materials. Although no molecular differences in the FBR to both polymers were found, the thick tissue capsule formed around Parylene C puts some concern on its use as a scaffold for intraneural electrodes.
Ajuts: European Commission 611687
Instituto de Salud Carlos III RD12-0019-0011
Instituto de Salud Carlos III CB06-05-1105
MINECO/SEV-2013-0295
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Biomedical materials ; Inflammation ; Peripheral nervous system
Publicat a: Scientific reports (Nature Publishing Group), Vol. 8 (April 2018) , art. 5965, ISSN 2045-2322

DOI: 10.1038/s41598-018-24502-z
PMID: 29654317


12 p, 2.6 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut Català de Nanociència i Nanotecnologia (ICN2)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2019-07-30, darrera modificació el 2021-08-01



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