Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum
Puighermanal, Emma (Universitat Autònoma de Barcelona. Institut de Neurociències)
Castell, Laia (Université Montpellier)
Esteve-Codina, Anna (Centre de Regulació Genòmica)
Melser, Su (Université de Bordeaux)
Kaganovsky, Konstantin (Stanford University School of Medicine)
Zussy, Charleine (Université Montpellier)
Boubaker-Vitre, Jihane (Université Montpellier)
Gut, Marta (Universitat Pompeu Fabra)
Rialle, Stephanie (Université Montpellier)
Kellendonk, Christoph (New York State Psychiatric Institute)
Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències)
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Marsicano, Giovanni (Université de Bordeaux)
Martin, Miquel (Université Montpellier)
Rubinstein, Marcelo (University of Michigan Medical School)
Girault, Jean-Antoine (Institut du Fer à Moulin)
Ding, Jun B. (Stanford University School of Medicine)
Valjent, Emmanuel (Université Montpellier)

Date:	2020
Abstract:	Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly but differentially contribute to the fine regulation of movement. However, their region-specific molecular features are presently unknown. By combining RNAseq of striatal D2R neurons and histological analyses, we identified hundreds of novel region-specific molecular markers, which may serve as tools to target selective subpopulations. As a proof of concept, we characterized the molecular identity of a subcircuit defined by WFS1 neurons and evaluated multiple behavioral tasks after its temporally-controlled deletion of D2R. Consequently, conditional D2R knockout mice displayed a significant reduction in digging behavior and an exacerbated hyperlocomotor response to amphetamine. Thus, targeted molecular analyses reveal an unforeseen heterogeneity in D2R-expressing striatal neuronal populations, underlying specific D2R's functional features in the control of specific motor behaviors.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Nature communications, Vol. 11 (april 2020) , ISSN 2041-1723

DOI: 10.1038/s41467-020-15716-9
PMID: 32327644

15 p, 5.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles