Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
Castelblanco, Esmeralda (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Betriu, Àngels (Institut de Recerca Biomèdica de Lleida)
Hernández, Marta (Hospital Arnau de Vilanova (Lleida, Catalunya))
Granado-Casas, Minerva (Institut de Recerca Biomèdica de Lleida)
Ortega, Emilio (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Soldevila i Madorell, Berta (Universitat Autònoma de Barcelona. Departament de Medicina)
Ramírez-Morros, Anna (Institut Germans Trias i Pujol)
Franch-Nadal, Josep (Institut Català de la Salut)
Puig Domingo, Manuel (Institut Germans Trias i Pujol)
Fernández, Elvira (Institut de Recerca Biomèdica de Lleida)
Avogaro, Angelo (University of Padova Padova, Italy)
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)

Date:	2019
Abstract:	The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49. 5% women; age 54 ± 9. 8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48. 6% vs. 73. 1%). In contrast, the proportion with only echogenic (25. 2% vs. 7. 5%) and calcified plaques (9. 4% vs. 1. 5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49. 5% vs. 26. 9% p = 0. 005). In addition to diabetes (OR 2. 28; p = 0. 026), age (OR 1. 06, p = 0. 002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques.
Grants:	Instituto de Salud Carlos III PI12/0183 Instituto de Salud Carlos III PI15/0625
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Type 1 diabetes ; Plaque characteristics ; Carotid plaque ; Echogenic plaque
Published in:	Journal of clinical medicine, Vol. 8 (march 2019) , ISSN 2077-0383

DOI: 10.3390/jcm8040424
PMID: 30925670

12 p, 983.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles