To Achieve an Earlier IFN-γ Response Is Not Sufficient to Control Mycobacterium tuberculosis Infection in Mice
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Prats, Clara (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear)
Marzo, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Barril, Carles (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear)
Vegué, Marina (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear)
Díaz, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Valls, Joaquim (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear)
López, Daniel (Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear)
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2014
Abstract:	The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.
Grants:	Ministerio de Ciencia e Innovación CGL2010-20160 Ministerio de Ciencia e Innovación CP13/00174
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 9 (june 2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0100830
PMID: 24959669

8 p, 406.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles