Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?
Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València))
Resmini, Eugenia (Institut d'Investigació Biomèdica Sant Pau)
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mora, Mireia (Hospital Clínic i Provincial de Barcelona)
Llatjós, Mariona (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sesmilo, Gemma (Hospital Universitari Dexeus (Barcelona, Catalunya))
Rius, Ferran (Hospital Arnau de Vilanova (Lleida, Catalunya))
Halperin, Irene (Hospital Clínic i Provincial de Barcelona)
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau)
Ricart, Veronica (Hospital Universitari de la Ribera (València))
Riesgo, Pedro (Hospital Universitari de la Ribera (València))
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2014
Abstract:	Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59±13 years; disease duration 6. 7±7. 2 years) and 50 controls (51% males, mean age 58±15 years) were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0. 5 and 1. 0 cm and in all nodules greater than 1. 0 cm. Goiter was more frequently found in patients than in controls (24. 9 vs. 8. 3%, respectively; p<0. 001). Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64. 6%, vs. 28. 6%, p<0. 05 and 53. 3 vs. 28. 6%, respectively; p<0. 05), and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3. 3% of patients with thyroid nodules), representing 1. 6% of the entire group of patients with acromegaly (2. 4% including a case with previously diagnosed papillary thyroid carcinoma). These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 9 (august 2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0104174
PMID: 25127456

6 p, 280.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles