The Dual Role of Platelets in the Cardiovascular Risk of Chronic Inflammation
Zamora, Carlos (Institut d'Investigació Biomèdica Sant Pau)
Cantó, Elisabet (Institut d'Investigació Biomèdica Sant Pau)
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)

Date:	2021
Abstract:	Patients with chronic inflammatory diseases often exhibit cardiovascular risk. This risk is associated with the systemic inflammation that persists in these patients, causing a sustained endothelial activation. Different mechanisms have been considered responsible for this systemic inflammation, among which activated platelets have been regarded as a major player. However, in recent years, the role of platelets has become controversial. Not only can this subcellular component release pro- and anti-inflammatory mediators, but it can also bind to different subsets of circulating lymphocytes, monocytes and neutrophils modulating their function in either direction. How platelets exert this dual role is not yet fully understood.
Grants:	Instituto de Salud Carlos III PI17/00072 Instituto de Salud Carlos III PI20/00184
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Platelet ; Chronic inflammation ; Cardiovascular risk ; Leukocytes ; Systemic inflammation
Published in:	Frontiers in immunology, Vol. 12 (january 2021) , p. 625181, ISSN 1664-3224

DOI: 10.3389/fimmu.2021.625181
PMID: 33868242

9 p, 273.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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