Mouse Models for Mycobacterium tuberculosis Pathogenesis : Show and Do Not Tell
Soldevilla, Pablo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vilaplana, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol

Date:	2022
Abstract:	Science has been taking profit from animal models since the first translational experiments back in ancient Greece. From there, and across all history, several remarkable findings have been obtained using animal models. One of the most popular models, especially for research in infectious diseases, is the mouse. Regarding research in tuberculosis, the mouse has provided useful information about host and bacterial traits related to susceptibility to the infection. The effect of aging, sexual dimorphisms, the route of infection, genetic differences between mice lineages and unbalanced immunity scenarios upon Mycobacterium tuberculosis infection and tuberculosis development has helped, helps and will help biomedical researchers in the design of new tools for diagnosis, treatment and prevention of tuberculosis, despite various discrepancies and the lack of deep study in some areas of these traits.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Tuberculosis ; Mouse ; C3HeB/FeJ ; Vaccines ; Immunopathology ; Chemotherapy ; Tolerance ; Resistance ; History
Published in:	Pathogens, Vol. 12 (december 2022) , ISSN 2076-0817

DOI: 10.3390/pathogens12010049
PMID: 36678397

33 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles