Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia
Falguera, Mireia (Universitat de Lleida)
Vilanova, Maria Belén (Universitat de Lleida)
Alcubierre, Nuria (Avantmedic (Lleida))
Granado-Casas, Minerva (Institut d'Investigació Biomèdica Sant Pau)
Marsal, Josep Ramon (Hospital Universitari Vall d'Hebron)
Miró, Neus (Institut Català de la Salut)
Cebrian, Cristina (Institut Català de la Salut)
Molló, Àngels (Institut Català de la Salut)
Franch-Nadal, Josep (Institut Català de la Salut)
Mata-Cases, Manel (Institut Català de la Salut)
Castelblanco, Esmeralda (Institut d'Investigació Biomèdica Sant Pau)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes. Design Prospective observational cohort study. Setting General population from a semi-rural area. Participants The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014. The prevalence of undiagnosed diabetes was 20, 3. 4% (95% CI 2. 6 to 4. 2) and that of pre-diabetes was 229, 39. 3% (37. 3 to 41. 3). Among those with pre-diabetes, 18. 3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58. 1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5. 7 to <6. 5) and 23. 6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41. 6%(37. 8 to 45. 4) returned to normoglycaemia, 57. 6% (57. 8 to 61. 4) persisted in pre-diabetes and 0. 6% (0 to 1. 2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1. 033; 1. 011 to 1. 056), higher physical activity (0. 546; 0. 360 to 0. 827), body mass index (1. 121; 1. 029 to 1. 222) and a family history of diabetes (1. 543; 1. 025 to 2. 323). The variables significantly associated with glycaemic normalisation were older age (0. 948; 0. 916 to 0. 982) and body mass index (0. 779; 0. 651 to 0. 931). Conclusions Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3. 4% and that of pre-diabetes was 39. 3%. After a 1-year follow-up, a small proportion of subjects (0. 6%) with pre-diabetes progressed to diabetes, while a high proportion (41. 6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Prediabetes ; Prediabetes prevalence ; Undiagnosed diabetes
Published in:	BMJ open, Vol. 10 Núm. 1 (20 2020) , p. 33332, ISSN 2044-6055

DOI: 10.1136/bmjopen-2019-033332
PMID: 31964673

9 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles