Clinical management of epidermal growth factor receptor mutation-positive non-small cell lung cancer patients after progression on previous epidermal growth factor receptor tyrosine kinase inhibitors : The necessity of repeated molecular analysis
González-Larriba, José Luis (Hospital Universitario Clínico San Carlos (Madrid))
Lázaro-Quintela, Martín (Complexo Hospitalario Universitario de Vigo)
Cobo, Manuel (Hospital Regional Universitario de Málaga)
Dómine, Manuel (Hospital Universitario Fundación Jiménez Díaz)
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña)
Universitat Autònoma de Barcelona

Data:	2017
Resum:	One of the most important advances in the treatment of non-small cell lung cancer (NSCLC) has been the identification of molecular alterations vulnerable to targeted inhibition, such as mutations in the epidermal growth factor receptor (EGFR) gene. EGFR tyrosine kinase inhibitors (EGFR-TKIs) are targeted agents used to treat EGFR mutation-positive advanced NSCLC showing significant improvements in terms of response rate (RR) and progression-free survival (PFS) compared to conventional chemotherapy. However, all patients eventually develop resistance to first-line EGFR-TKIs. The most common mechanism of acquired resistance is the secondary acquisition of a single missense mutation within exon 20 in the EGFR gene, known as the T790M mutation (49-60%). New agents targeting the T790M mutation have undergone clinical development, and among these, osimertinib has shown significant activity in relapsing EGFR mutation positive patients harbouring the T790M mutation. Although precision medicine is a reality for NSCLC, obtaining relevant tissue for repeated molecular analysis from these patients remains a challenge. In this article, a group of experts from the Spanish Society of Medical Oncology (SEOM) and the Spanish Lung Cancer Group (GECP) evaluated the role of rebiopsy and the potential application of plasma-testing methodologies in advanced EGFR mutation patients progressing after EGFR-TKI.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Matèria:	Epidermal growth factor receptor (EGFR) ; Liquid biopsy ; Osimertinib ; Rebiopsy ; Tyrosine kinase inhibitor (TKI)
Publicat a:	Translational Lung Cancer Research, Vol. 6 (january 2017) , p. S21-S34, ISSN 2226-4477

DOI: 10.21037/tlcr.2017.10.03
PMID: 29299405

14 p, 563.4 KB

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