Splanchnic Vein Thrombosis in Inflammatory Bowel Disease : An Observational Study from the ENEIDA Registry and Systematic Review
Puig, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mesonero, Francisco (Hospital Universitario Ramón y Cajal (Madrid))
Menchén, Luís (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Bujanda, Luis (Universidad del País Vasco)
Castro, Jesús (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
González-Partida, Irene (Hospital Puerta de Hierro (Madrid))
Vicente, Raquel (Hospital Universitario Miguel Servet)
González-Muñoza, Carlos (Institut d'Investigació Biomèdica Sant Pau)
Iborra, Marisa (Hospital Universitari i Politècnic La Fe (València))
Sierra Ausín, Mónica (Complejo Asistencial Universitario de León)
Huguet, José María (Hospital General Universitario de Valencia)
García García, María José (Universidad de Cantabria)
de Francisco, Ruth (Hospital Universitario Central de Asturias)
García-Alonso, Francisco Javier (Hospital Río Hortega)
Mañosa Ciria, Míriam (Hospital Universitario Ramón y Cajal (Madrid))
Domènech, Eugeni (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2023
Abstract:	Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn's disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Inflammatory bowel disease ; Outcome ; Prevalence ; Splanchnic vein thrombosis
Published in:	Journal of clinical medicine, Vol. 12 (november 2023) , ISSN 2077-0383

DOI: 10.3390/jcm12237366
PMID: 38068418

15 p, 845.3 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles