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1.
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11 p, 1.4 MB |
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
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Marques-Pamies, Montserrat (Hospital Municipal de Badalona) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández García, Marta (Hospital Universitari Arnau de Vilanova) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Giménez-Palop, Olga (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martínez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pons, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Taibo, Rocío (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Araujo-Castro, Marta (Hospital Ramón y Cajal) ;
Blanco, Concepción (Hospital Universitario Príncipe de Asturias) ;
Simón, Inmaculada (Hospital Universitari Joan XXIII de Tarragona) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pavón, Isabel (Hospital Universitario de Getafe) ;
García-Centeno, Rogelio (Hospital General Universitari Gregorio Marañón) ;
Zavala, Roxana (Hospital Universitari Joan XXIII de Tarragona) ;
Hanzu, Felicia A (Hospital Clínic i Provincial de Barcelona) ;
Mora, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Aulinas, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vilarrasa, Nuria (Instituto de Salud Carlos III) ;
Librizzi, Soledad (Hospital Universitario 12 de Octubre) ;
Calatayud, María (Hospital Universitario 12 de Octubre) ;
de Miguel, Paz (Hospital Clínico San Carlos (Madrid)) ;
Alvarez-Escola, Cristina (Hospital Universitario La Paz) ;
Picó Alfonso, Antonio M (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Sampedro, Miguel (Hospital Universitario de La Princesa) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Webb, S. M 1952- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
We previously described that a short version of the acute octreotide test (sAOT) can predict the response to first-generation somatostatin receptor ligands (SRLs) in patients with acromegaly. We have prospectively reassessed the sAOT in patients from the ACROFAST study using current ultra-sensitive GH assays. [...]
2023 -  10.3389/fendo.2023.1269787
Frontiers in Endocrinology, Vol. 14 (october 2023)
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2.
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8 p, 366.3 KB |
Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly
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Ruiz-Janer, Sabina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Venegas, Eva (Hospital Universitario Virgen del Rocío (Andalusia)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Garcia-Centeno, Rogelio (Hospital Universitario Gregorio Marañón) ;
Gálvez, María Ángeles (Hospital Universitario Reina Sofía (Andalusia)) ;
Picó Alfonso, Antonio M. (Hospital General Universitario de Alicante) ;
Maraver, Silvia (Hospital Universitario Virgen de la Victoria (Andalusia)) ;
González, Inmaculada (Hospital Regional Universitario de Málaga) ;
Abellán-Galiana, Pablo (Hospital General Universitario de Castelló) ;
Trincado, Pablo (Hospital Universitario Miguel Servet (Saragossa)) ;
Herrera, Mayte T. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Olvera, Pilar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bernabeu Morón, Ignacio (Complejo Universitario de Santiago de Compostela) ;
Serra-Soler, Guillermo (Hospital Universitari Son Espases (Illes Balears)) ;
Azriel, Sharona (Hospital Universitario Infanta Sofía (Madrid)) ;
García, Lourdes (Hospital Universitario de Jerez (Illes Canàries)) ;
Carvalho, Davide (Centro Hospitalar Universitário de São João (Portugal)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig, Josep (Hospital Universitari de Girona Doctor Josep Trueta) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objective: Hyperintensity signal in T2-weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment in acromegaly. The aim of the study was to evaluate T2 MRI signal intensity and its relation with pasireotide therapeutic effectiveness in real-life clinical practice. [...]
2023 - 10.1111/cen.14946
Clinical Endocrinology, Vol. 99 Núm. 4 (october 2023) , p. 378-385
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3.
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16 p, 3.0 MB |
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
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Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Casano-Sancho, Paula (Hospital Sant Joan de Déu (Manresa)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Sesmilo, Gemma (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Marcos-Ruiz, Jennifer (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez-Lloveras, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rueda-Pujol, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aulinas, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Muñoz, Fernando (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rico, Marta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ibáñez-Domínguez, Javier (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Cordero Asanza, Esteban (Hospital Universitari Vall d'Hebron) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in a significant number of tumors, including pituitary adenomas. [...]
2023 - 10.3389/fendo.2023.1129213
Frontiers in Endocrinology, Vol. 14 (march 2023)
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4.
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14 p, 1.9 MB |
Data mining analyses for precision medicine in acromegaly : a proof of concept
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol) ;
Sampedro, Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Picó Alfonso, Antonio M (Universidad Miguel Hernández de Elche. Departamento de Medicina Clínica) ;
García-Martínez, Araceli (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Martel-Duguech, Luciana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sardon, Teresa (Anaxomics Biotech S.L.) ;
Simó-Servat, Andreu (Hospital Universitari Mútua Terrassa. Servei d'Endocrinologia) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Villabona, Carles (Hospital Universitari de Bellvitge) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Fajardo-Montañana, Carmen (Hospital de La Ribera (Alzira). Servicio de Endocrinología) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Lamas, Cristina (Hospital General Universitario de Albacete. Servicio de Endocrinología) ;
Alvarez, Clara V. (Universidade de Santiago de Compostela) ;
Bernabeu Morón, Ignacio (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig-Domingo, Manel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there is no consensus criterion on how to assign this pharmacologic treatment according to biomarker levels. [...]
2022 - 10.1038/s41598-022-12955-2
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 8979
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5.
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17 p, 24.9 MB |
Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Martínez, Araceli (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Rodríguez-Lloveras, Helena (Institut Germans Trias i Pujol) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Simó-Servat, Andreu (Mútua de Terrassa) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Picó Alfonso, Antonio M (Universidad de Miguel Hernández de Elche) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. [...]
2022 - 10.3390/biomedicines10020460
Biomedicines, Vol. 10 (february 2022)
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6.
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29 p, 1.4 MB |
Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer
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Pardo, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Jordà, Mireia (Institut Germans Trias i Pujol)
Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. [...]
2022 - 10.3390/nu14040851
Nutrients, Vol. 14 Núm. 4 (february 2022) , p. 851
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7.
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9 p, 714.0 KB |
Pasireotide in the Personalized Treatment of Acromegaly
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Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Endocrinology & Nutrition Service, Complejo Universitario de Santiago de Compostela) ;
Picó Alfonso, Antonio M (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez, María-Angeles (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Aller, Javier (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Universitat Autònoma de Barcelona
The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. [...]
2021 - 10.3389/fendo.2021.648411
Frontiers in Endocrinology, Vol. 12 (march 2021)
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8.
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7 p, 314.9 KB |
Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly
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Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. [...]
2021 - 10.3389/fendo.2021.646210
Frontiers in Endocrinology, Vol. 12 (march 2021)
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9.
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15 p, 1.7 MB |
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications
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Carrillo-Reixach, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Simón-Coma, Marina (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Domingo-Sàbat, Montse (Institut Germans Trias i Pujol) ;
Abril-Fornaguera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Akers, N. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Sala Llinas, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ragull, Sonia (Institut Germans Trias i Pujol) ;
Arnal, Magdalena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villalmanzo, Núria (Institut Germans Trias i Pujol) ;
Cairo, Stefano (Instituto di Ricerca Pediatrica. Corso Stati Uniti 4) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Kappler, R. (Department of Pediatric Surgery. Dr. von Hauner Children's Hospital. Ludwig-Maximilians-University Munich) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Guerra, Laura (Hospital Universitario La Paz (Madrid)) ;
Sábado, Constantino (Hospital Universitari Vall d'Hebron) ;
Guillén, Gabriela (Hospital Universitari Vall d'Hebron) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol) ;
Vázquez-Vitali, María (Institut Germans Trias i Pujol) ;
Kuchuk, O. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Mateos, María Elena (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ramírez, G. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Santamaría, María (Hospital Universitario La Paz (Madrid)) ;
Mozo, Y. (Hospital Universitario La Paz (Madrid)) ;
Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grotzer, M. (Department of Pediatric Oncology. University Children's Hospital Zurich. University of Zurich) ;
Branchereau, S. (Bicêtre Hospital) ;
de Andoin, N. G. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
López-Ibor, B. (Department of Pediatric Hematology and Oncology. HM Montepríncipe Hospital) ;
López-Almaraz, R. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Salinas, J. A. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Torres, B. (Hospital Universitari i Politècnic La Fe (València)) ;
Hernández, Francisco (Hospital Universitario La Paz (Madrid)) ;
Uriz, J. J. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Fabre, M. (Department of Pathology. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris. Université Paris Descartes) ;
Blanco, J. (Joan) (Joan) (Universitat de Vic - Universitat Central de Catalunya) ;
Paris, C. (Stem Cell Transplant Unit. Hospital Luis Calvo Mackenna) ;
Bajčiová, V. (Department of Pediatric Oncology. Childrens University Hospital Brno) ;
Laureys, G. (Ghent University Hospital. (Bèlgica)) ;
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beléndez, Cristina (Hospital General Universitario Gregorio Marañón) ;
Guettier, C. (Bicêtre Hospital) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Czauderna, P. (Department of Surgery and Urology for Children and Adolescents. Medical University of Gdansk) ;
Morland, B. (Birmingham Women's Hospital) ;
Sia, D. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Losic, B. (Icahn Institute for Data Science and Genomic Technology (Nova York, Estats Units d'Amèrica)) ;
Buendia, M. A. (INSERM. UMR 1193. Paul-Brousse Hospital. Hepatobiliary Centre) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Llovet, J. M. (Institució Catalana de Recerca i Estudis Avançats) ;
Armengol, Carolina (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB. [...]
2020 - 10.1016/j.jhep.2020.03.025
Journal of Hepatology, Vol. 73 Núm. 2 (august 2020) , p. 328-341
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10.
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22 p, 1.4 MB |
Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression
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Forn Bernaus, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Merlos-Suárez, Anna (Institute for Research in Biomedicine (IRB Barcelona)) ;
Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Lois, Sergio (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Batlle, Eduard (Institute for Research in Biomedicine (IRB Barcelona)) ;
Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. [...]
2015 - 10.1371/journal.pone.0123263
PloS one, Vol. 10, No. 5 (May 2015) , p. e0123263
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