Integrating mechanical and biological control of cell proliferation through bioinspired multi-effector materials
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Tatkiewicz, Witold (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Ratera Bastardas, Imma (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Veciana i Miró, Jaume (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")

Date:	2015
Abstract:	In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bioinspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.
Grants:	Instituto de Salud Carlos III FIS/PI12/00327 Ministerio de Economía y Competitividad BIO2013-41019P
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Topography ; Regenerative medicine ; Adhesion proteins ; Hydrogels ; Growth factor release ; Bioscaffolds
Published in:	Nanomedicine, Vol. 10 issue 5 (2015) , p. 873-891, ISSN 1748-6963

DOI: 10.2217/nnm.15.5

Post-print 32 p, 866.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles