Home > Articles > Published articles > Integrating mechanical and biological control of cell proliferation through bioinspired multi-effector materials |
Date: | 2015 |
Abstract: | In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bioinspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination. |
Grants: | Instituto de Salud Carlos III FIS/PI12/00327 Ministerio de Economía y Competitividad BIO2013-41019P |
Rights: | Tots els drets reservats. |
Language: | Anglès |
Document: | Article ; recerca ; Versió acceptada per publicar |
Subject: | Topography ; Regenerative medicine ; Adhesion proteins ; Hydrogels ; Growth factor release ; Bioscaffolds |
Published in: | Nanomedicine, Vol. 10 issue 5 (2015) , p. 873-891, ISSN 1748-6963 |
Post-print 32 p, 866.9 KB |